Results 151 to 160 of about 2,142,199 (296)
Investigation of P16 gene hypermethylation in serum of gastric cancer patients in Ardabil province [PDF]
Gastric cancer is the second leading cause of cancer death in the world. There is evidence that shows genetic and epigenetic change in stomach cancer is as a result of a variety of oncogenes, tumor suppressor genes, genes that repair the DNA, genes ...
وثوقی, ابراهیم +8 more
core
Expression of p16 protein in breast cancer
Breast cancer is the most common cancer and a leading cause of death in women in Saudi Arabia. P16 is a tumour suppressor gene that plays a crucial role in regulating cell cycle.
Saad Samargandy +3 more
core +1 more source
Activating senescence in p16-positive Basal-like breast cancer. [PDF]
, 2016 PhDBreast cancer is the most common cancer in the UK and Basal-like breast cancer (a highly aggressive subtype) accounts for approximately 8-22% of all cases depending on ethnicity.
Moore, Madeleine
core
Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer
The FEBS Journal, EarlyView.Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa +2 more
wiley +1 more source
Merkel cell carcinoma: an updated guide for pathologists
Histopathology, EarlyView.Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley +1 more source
Distinct Rb expression pattern in HPV‐associated neuroendocrine carcinomas of the uterine cervix
Histopathology, EarlyView.Most uterine cervical neuroendocrine carcinoma (UCNEC) cases are HPV‐associated and are characterized by partial loss of Rb, p16 overexpression, and cyclin D1 negativity. A minority of UCNECs exhibit a distinct pattern, characterized by HPV negativity, retained Rb expression, focal p16 expression and cyclin D1 positivity.
Nobuko Yasutake +12 more
wiley +1 more source
International Journal of Cosmetic Science, EarlyView.Integrated chemical profiling, transcriptomics and functional validation reveal the multifunctional benefits of a triple‐ferment filtrate complex for skin aging intervention. Abstract Objective Skin aging is driven by interconnected hallmarks including oxidative stress and chronic low‐grade inflammation, cellular senescence, impaired epidermal function
Ping Gao +4 more
wiley +1 more source
European Journal of Histochemistry, 2009 p16INK4a and p53 are tumor-suppressor genes frequently altered in various malignancies, including cutaneous melanoma. The purpose of the study was to establish the prognostic value of immunohistochemical expression of p16INK4a and p53 in sporadic ...
P Sirigu +8 more
doaj
EBI3‐Dependent Pathways Coordinate Regulatory and Effector Immunity During Cutaneous Leishmaniasis
Immunology, EarlyView.The mechanisms coordinating immunoregulatory and protective responses during Leishmania braziliensis infection remain poorly understood. Here, using experimental models, we investigated the role of EBI3, a shared subunit of IL‐27 and IL‐35, in cutaneous leishmaniasis. EBI3 deficiency exacerbated lesion development and parasite burden and was associated
Maria Tays Mendes +10 more
wiley +1 more source
Methylation of E-cadherin and hMLH1 genes in Indian sporadic breast carcinomas
, 2006 Hypermethylation of promoter regions leading to inactivation of tumor suppressor genes is a common event in the progression of several tumor types. We have employed a novel restriction digestion based multiplex PCR assay to analyse the methylation status
Shanmugam, G. +4 more
core +1 more source