Results 11 to 20 of about 7,394,141 (337)
Neoplasia: An International Journal for Oncology Research, 2006 Aberrant methylation in gene promoter regions leads to transcriptional inactivation of cancer-related genes and plays an integral role in tumorigenesis.
Yang Liu +4 more
doaj +3 more sources
p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.
PLoS ONE, 2011 BackgroundThe cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer.
Huda H Al-Khalaf +8 more
doaj +2 more sources
Epigenetic Changes in Tumor Suppressor Genes, P15, P16, APC-3 and E-cadherin in Body Fluid
Kaohsiung Journal of Medical Sciences, 2007 The inactivation of tumor suppressor genes by promoter methylation plays an important role in the development of cancers; it can also be used as a marker to distinguish cancerous cells from non-cancer cells.
Mei-Ling Chen +4 more
doaj +2 more sources
Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesTo evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors.MethodsEighty thyroid tumor cases (20 follicular adenomas, 10 follicular ...
Jin Hwan Kim +4 more
doaj +4 more sources
Digital Spatial Profiling identifies distinct patterns of immuno-oncology-related gene expression within oropharyngeal tumours in relation to HPV and p16 status [PDF]
Frontiers in OncologyBackgroundThe incidence of oropharyngeal cancer (OPC) is increasing, due mainly to a rise in Human Papilloma Virus (HPV)-mediated disease. HPV-mediated OPC has significantly better prognosis compared with HPV-negative OPC, stimulating interest in ...
Jill M. Brooks +8 more
doaj +2 more sources
Journal of Pure and Applied Microbiology, 2019 Oral carcinogenesis is a multi-step process, affecting predominantly elderly males with a long history of smoking and alcohol drinking while the role of infectious agents in its progression has not been fully identified.
Hayat Ghaith Sachit +4 more
doaj +2 more sources
Inactivation of the p16 Tumor Suppressor Gene in Adrenocortical Tumors [PDF]
Journal of Clinical Endocrinology & Metabolism, 1999 The mechanisms of adrenocortical tumorigenesis are still unknown. Evidence that the majority of adrenocortical tumors are monoclonal in origin suggests that a progressive accumulation of genetic aberrations, due to activation of protooncogenes and/or inactivation of tumor suppressor genes, leads to abnormal cell proliferation through a multistep ...
PILON C +6 more
openaire +4 more sources
Translational Oncology, 2009 BACKGROUND Aberrant DNA methylation has been recognized in human breast carcinogenesis as a common molecular alteration associated with the loss of expression of a number of key regulatory genes.
M. Raish +10 more
semanticscholar +2 more sources
Clinical and Applied Thrombosis/HemostasisObjective DNA methylation, as an epigenetic alteration, plays an essential role in the development of atherosclerosis and venous thrombosis. E-cadherin, a tumor suppressor gene and adhesion molecule, has a crucial function in platelet aggregation and ...
Niloofar Abak M.Sc +5 more
doaj +2 more sources
Alteration of p16 and p15 genes in human uterine tumours [PDF]
British Journal of Cancer, 1999 SummaryThe roles of the p16 and p15 inhibitor of cyclin-dependent kinase tumour suppressor genes were examined in human uterine cervical and endometrial cancers.
R. Nakashima +11 more
semanticscholar +3 more sources