Results 31 to 40 of about 7,394,141 (337)

p16 Gene Expression in Basal Cell Carcinoma [PDF]

Archives of Medical Research, 2008
Basal cell carcinoma (BCC) develops predominantly in sun-exposed skin in fair-skinned individuals prone to sunburn. BCC typically occurs in adults. High exposure to ultraviolet (UV) radiation increases rate of developing BCC, a slowly growing tumor that occurs in hair-growing squamous epithelium and rarely metastasizes. In genetic studies, BCC patients
Eshkoor, Sima Atoallahi, Ismail, Patimah, Abdul Rahman, Sabariah, Oshkour, Soraya Ataollahi   +3 more
openaire   +2 more sources

Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).

PLoS ONE, 2020
Human papilloma virus (HPV) causes a subset of head and neck squamous cell carcinomas (HNSCC) of the oropharynx. We combined targeted DNA- and genome-wide RNA-sequencing to identify genetic variants and gene expression signatures respectively from ...
Nabil F Saba, Ashok R Dinasarapu, Kelly R Magliocca, Bhakti Dwivedi, Sandra Seby, Zhaohui S Qin, Mihir Patel, Christopher C Griffith, Xu Wang, Mark El-Deiry, Conor Ernst Steuer, Jeanne Kowalski, Dong Moon Shin, Michael E Zwick, Zhuo Georgia Chen   +14 more
doaj   +1 more source

Promoter Hypermethylation Profile of Tumour Suppressor Genes in Oral Leukoplakia and Oral Squamous Cell Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2014
Purpose of the Study: The present study was conducted to evaluate epigenetic alteration of five tumour suppressor genes in the oral precancer and cancer patients.
G. S. Asokan, S. Jeelani, N.Gnanasundaram   +2 more
doaj   +1 more source

Differential p16 expression levels in the liver, hepatocytes and hepatocellular cell lines [PDF]

PeerJ, 2021
Background One of the most frequently deleted genes in cancer is CDKN2A encoding p16. This protein is often overexpressed in senescent cells, while its suppression can bypass the oncogene-induced senescence to enable transformation and tumorigenesis. The
Barbara Kramar, Dušan Šuput, Irina Milisav   +2 more
doaj   +2 more sources

Cellular senescence and tumor suppressor gene p16 [PDF]

International Journal of Cancer, 2011
AbstractCellular senescence is an irreversible arrest of cell growth. Biochemical and morphological changes occur during cellular senescence, including the formation of a unique cellular morphology such as flattened cytoplasm. Function of mitochondria, endoplasmic reticulum and lysosomes are affected resulting in the inhibition of lysosomal and ...
Hani, Rayess, Marilene B, Wang, Eri S, Srivatsan   +2 more
openaire   +2 more sources

Relation of the methylation state of RUNX3 and p16 gene promoters with hepatocellular carcinoma in Egyptian patients

Egyptian Journal of Medical Human Genetics, 2022
Background Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy of adults. RUNX3 and p16 are tumor suppressor genes that may be inactivated by hypermethylation which is a key epigenetic mechanism that contributes to the initiation
Fatma El-shaarawy, Mai M. Abo ElAzm, Rasha H. Mohamed, Mohamed I. Radwan, Dina M. Abo-Elmatty, Eman T. Mehanna   +5 more
doaj   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2-Mediated DNA Damage Response. [PDF]

Adv Sci (Weinh)
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Yang T, Shen T, Qiu Y, Zhang W, Zheng Z, Sun J, Yao Y, Yao M, Li J.   +8 more
europepmc   +2 more sources

High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans

Clinical Epigenetics, 2017
BackgroundChanges in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12) involved in one-carbon metabolism
H. Sánchez, M. B. Hossain, L. Lera, S. Hirsch, C. Albala, R. Uauy, K. Broberg, A. Ronco   +7 more
semanticscholar   +1 more source

DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [PDF]

, 2014
Background: Hypermethylation in promoter regions of genes might lead to altered gene functions and result in malignant cellular transformation. Thus, biomarker identification for hypermethylated genes would be very useful for early diagnosis, prognosis ...
Zain, R. B., Vincent-Chong, V. K., Tan, A. C., Khor, G. H., Thong, K. L., Omar, E., Froemming, G. R. A., Abraham, M. T., Tan, S. K.   +8 more
core   +1 more source

Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK

Oncology Report, 2016
5-Aza-2′-deoxycytidine (5-Aza-CdR) is currently acknowledged as a demethylation drug, and causes a certain degree of demethylation in a variety of cancer cells, including pancreatic cancer cells.
Feng-Ping Pan, Hong-Kun Zhou, H. Bu, Zi-Qiang Chen, H. Zhang, Lu-ping Xu, Jian Tang, Qing-Jiang Yu, Yong-Quan Chu, Jie Pan, Yong Fei, Sheng-zhang Lin, Dian-Lei Liu, Liang Chen   +13 more
semanticscholar   +1 more source