Results 51 to 60 of about 7,394,141 (337)

Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival

Respiratory Research, 2022
Background Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction of cell cycle arrest, cellular senescence, and pro-fibrotic gene expression.
Jonathan Keow, Matthew J. Cecchini, Nathashi Jayawardena, Maurizio Zompatori, Mariamma G. Joseph, Marco Mura   +5 more
doaj   +1 more source

DNA hypermethylation of cell cycle (p15 and p16) and apoptotic (p14, p53, DAPK and TMS1) genes in peripheral blood of leukemia patients.

Asian Pacific Journal of Cancer Prevention, 2014
Aberrant DNA methylation of tumor suppressor genes has been reported in all major types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. However, most of the previous reports did not show the extent
K. Bodoor, Yazan Haddad, Asem M. Alkhateeb, Abdullah Al-Abbadi, Mohammad Dowairi, Ahmad Magableh, N. Bsoul, Abdulhameed Ghabkari   +7 more
semanticscholar   +1 more source

Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome.

Journal of Investigative Dermatology, 2002
There are few data on the molecular pathogenesis of cutaneous T cell lymphomas. A recent allelotyping study by our group identified frequent allelic loss on 9p, 10q, and 17p including losses on 9p21 in 16% of patients with mycosis fungoides and 46% with ...
J. Scarisbrick, A. Woolford, E. Calonje, A. Photiou, S. Ferreira, G. Orchard, R. Russell-Jones, S. Whittaker   +7 more
semanticscholar   +2 more sources

t(4;14)(p16;q32) [PDF]

, 2005
Review on t(4;14)(p16;q32), with data on clinics, and the genes ...
Viguié, F
core   +1 more source

Promoter Region Hypermethylation and mRNA Expression of MGMT and p16 Genes in Tissue and Blood Samples of Human Premalignant Oral Lesions and Oral Squamous Cell Carcinoma

BioMed Research International, 2014
Promoter methylation and relative gene expression of O6-methyguanine-DNA-methyltransferase (MGMT) and p16 genes were examined in tissue and blood samples of patients with premalignant oral lesions (PMOLs) and oral squamous cell carcinoma (OSCC ...
V. Bhatia, M. Goel, A. Makker, S. Tewari, Alka Yadu, P. Shilpi, Sandeep Kumar, S. Agarwal, S. K. Goel   +8 more
semanticscholar   +1 more source

Promoter hypermethylation of p16 and APC in gastrointestinal cancer patients

The Turkish Journal of Gastroenterology, 2014
Background/Aims: Cancer is a consequence of the disruption of cellular regulation. Epigenetic is one of the reasons of this disruption. Epigenetic factors play a role in the carcinogenesis by affecting proto-oncogenes and tumor suppressor genes and it is
Beril Erdem, Sibel Küçükyıldırım, Emel Sağlar, Zülfikar Polat, Hatice Mergen   +4 more
doaj   +1 more source

Comparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts

Scientific Reports, 2023
Anal squamous cell carcinoma (ASCC) is a rare tumor of the gastrointestinal tract. We aimed to compare the genetic backgrounds and their effect on clinical outcomes between Japanese and Caucasian patients with ASCC. Forty-one patients diagnosed with ASCC
Takahiko Ito, Daisuke Takayanagi, Shigeki Sekine, Taiki Hashimoto, Yoko Shimada, Maiko Matsuda, Masayoshi Yamada, Ryuji Hamamoto, Tomoyasu Kato, Dai Shida, Yukihide Kanemitsu, Narikazu Boku, Takashi Kohno, Atsuo Takashima, Kouya Shiraishi   +14 more
doaj   +1 more source

Epigenetic and genomic biomarker discovery in breast cancer [PDF]

, 2011
Breast cancer is the most common malignancy among females and the fifth most common cause of cancer death worldwide. The research for biomarker discovery for the diagnosis and prognosis of patients with breast cancer has been going on for decades ...
Radpour, Ramin
core   +1 more source

p16^INK4a hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell Carcinoma

BMC Cancer, 2010
Background Tumor suppressor genes p53 and p16INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis.
Memar Bahram, Moaven Omeed, Malekzadeh Reza, Khademi Hooman, Sotoudeh Masoud, Biramijamal Firouzeh, Taghavi Noushin, A'rabi Azadeh, Abbaszadegan Mohammad   +8 more
doaj   +1 more source

Correlation between HPV PCNA, p16, and p21 Expression in Lung Cancer Patients

Cellular Microbiology, 2022
Purpose. Evaluate if human papillomavirus (HPV) infection in lung cancer patients might be helping cancer development by altering p16, p21, and PCNA, key human genes involved in cell proliferation and tumor development. Methods.
B. F. São Marcos, T. H. A. de Oliveira, C. M. M. Do Amaral, M. T. C. Muniz, A. C. Freitas   +4 more
doaj   +1 more source