Results 11 to 20 of about 2,142,199 (296)

DNA Methylation Pattern and mRNA Expression Level of E-Cadherin and P16 Genes in Thrombotic Disorders

Clinical and Applied Thrombosis/Hemostasis
Objective DNA methylation, as an epigenetic alteration, plays an essential role in the development of atherosclerosis and venous thrombosis. E-cadherin, a tumor suppressor gene and adhesion molecule, has a crucial function in platelet aggregation and ...
Niloofar Abak M.Sc, Mehdi Azad Ph.D, Fatemeh Mohammad Ali Ph.D, Mostafa Saberian Ph.D, Saeed Turkaman M.Sc, Shaban Alizadeh Prof   +5 more
doaj   +2 more sources

Deletion of the p16 and p15 Genes in Human Bladder Tumors

JNCI Journal of the National Cancer Institute, 1995
Two genes, p16 (also known as CDKN2, INK4A, or MTS1) and p15 (also described as INK4B or MTS2), are found in tandem at chromosome 9p21. These genes are designated as candidate tumor suppressor genes because they encode proteins that function as negative cell cycle regulators. (The encoded polypeptides inactivate specific cyclin-protein kinase complexes
I, Orlow, L, Lacombe, G J, Hannon, M, Serrano, I, Pellicer, G, Dalbagni, V E, Reuter, Z F, Zhang, D, Beach, C, Cordon-Cardo   +9 more
openaire   +3 more sources

Clearance of p16-positive cardiac cells improves age-related cardiac remodeling in mice. [PDF]

Exp Physiol
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mehdizadeh M, Mackasey M, Gharagozloo K, Aguilar M, Naud P, Ochs A, Vuong-Robillard N, Thorin E, Ferbeyre G, Tardif JC, Sirois MG, Tanguay JF, Nattel S.   +12 more
europepmc   +2 more sources

MGP_HNSC32: A H&E Morphology-Derived 32-Gene Prognostic Signature in Head and Neck Squamous Cell Carcinoma. [PDF]

Cancer Med
ABSTRACT Head and neck squamous cell carcinoma (HNSC) exhibits substantial molecular and morphological heterogeneity, yet current morphology‐based prognostic models often lack biological interpretability. We developed a transformer‐based computational framework (CTransPath) to virtually predict gene expression directly from hematoxylin and eosin (H&E ...
Zhao D, Huang Z, Xu J, Zhang Z, Hess J, Feng B.   +5 more
europepmc   +2 more sources

Prognostic impact of p16 and p53 gene expressions in stage 1a epithelial ovarian cancer [PDF]

Obstetrics & Gynecology Science, 2020
Objective Epithelial ovarian cancer (EOC) is rarely detected at stage 1a. Most of the patients have a good prognosis and there are limited factors that affect their survival. In the present study, we evaluated the p16 and p53 gene expressions of stage 1a
Emre Günakan, Yusuf Aytaç Tohma, Latife Atasoy Karakaş, Hüseyin Akıllı, Asuman Nihan Haberal, Ali Ayhan   +5 more
doaj   +1 more source

Influence of some methylated hepatocarcinogenesis-related genes on the response to antiviral therapy and development of fibrosis in chronic hepatitis C patients [PDF]

Clinical and Molecular Hepatology, 2020
Background and Aim Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients ...
Waleed Seif Eldin Mohamed Mostafa, Mohammed Hassan Saiem Al-Dahr, Dalia Abdel Hamid Omran, Zeinab Fathy Abdullah, Suzan Hamdy Elmasry, Mohamed Nabil Ibrahim   +5 more
doaj   +1 more source

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers. [PDF]

Int J Cancer
ABSTRACT Penile cancer is a severe disease, and a large proportion is related to high‐risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population‐based data on the prevalence of p16 in penile cancer is scarce.
Stærk MG, Toft BG, Stilling C, Elversang J, Kjær-Frifeldt S, Hjulskov SH, Stifter-Vretenar S, Schou MA, Aagaard M, Petersen PM, Jakobsen JK, Munk C, Kjær SK.   +12 more
europepmc   +2 more sources

Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration

Journal of Orthopaedic Surgery and Research, 2022
Background p16, p53, and proliferating cell nuclear antigen (pcna) genes play significant roles in many chromatin modifications and have been found to be highly expressed in a variety of tumor tissues.
Dechao Cai, Xiao Ma, Huihui Guo, Haotian Zhang, Ashuai Bian, Haoran Yu, Wendan Cheng   +6 more
doaj   +1 more source

The relationship between P16 INK4A and TP53 promoter methylation and the risk and prognosis in patients with oesophageal cancer in Thailand

Scientific Reports, 2022
DNA methylation can regulate the expression of tumour suppressor genes P16 and TP53, environmental factors, which are both important factors related to an increased risk and prognosis of oesophageal cancer (EC). However, the association between these two
Arisara Poosari, Thitima Nutravong, Wises Namwat, Wiphawan Wasenang, Prakasit Sa-ngiamwibool, Piti Ungareewittaya   +5 more
doaj   +1 more source

The CDKN2A (p16) Gene and Human Cancer [PDF]

Molecular Medicine, 1997
CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds with familial atypical multiple mole/melanoma (FAMMM), also known as atypical mole syndrome.
Foulkes, William D., Flanders, Tamar Y., Pollock, Pamela M., Hayward, Nicholas K.   +3 more
openaire   +2 more sources