Results 21 to 30 of about 2,142,199 (296)

TOP2A Maintains Heterochromatin Stability by Sustaining LMNB1 Expression to Counteract Senescence. [PDF]

Aging Cell
Depletion of TOP2A accelerates MSC senescence and disrupts heterochromatin integrity. TOP2A directly regulates LMNB1 expression to maintain MSC nuclear integrity and epigenomic stability. Overexpression of TOP2A counteracts MSC senescence through Lamin B1‐mediated chromatin reorganization and epigenomic stabilization.
Cheng K, Wang Y, Pan Y, Zhang W, Yu D, Zhou Q, Zhong Z, Mei R, Xu C, Hayierhan A, Ma Y, Xu Y, Xie Q, Sun P, Zhou J, Zhou X.   +15 more
europepmc   +2 more sources

Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation [PDF]

Chinese Journal of Cancer Research, 2018
To investigate the relationship between the transcription of ANRIL, P15, P14 and P16 at the same locus and the regulation mechanism of ANRIL.Publicly available database of Cancer Cell Line Encyclopedia (CCLE) was used in bioinformatic analyses. Methylation of CpG islands was detected by denaturing high performance liquid chromatography (DHPLC).
Ying, Gan, Wanru, Ma, Xiuhong, Wang, Juanli, Qiao, Baozhen, Zhang, Chenghua, Cui, Zhaojun, Liu, Dajun, Deng   +7 more
openaire   +2 more sources

p16 Gene Expression in Basal Cell Carcinoma [PDF]

Archives of Medical Research, 2008
Basal cell carcinoma (BCC) develops predominantly in sun-exposed skin in fair-skinned individuals prone to sunburn. BCC typically occurs in adults. High exposure to ultraviolet (UV) radiation increases rate of developing BCC, a slowly growing tumor that occurs in hair-growing squamous epithelium and rarely metastasizes. In genetic studies, BCC patients
Eshkoor, Sima Atoallahi, Ismail, Patimah, Abdul Rahman, Sabariah, Oshkour, Soraya Ataollahi   +3 more
openaire   +2 more sources

The expression of steroidogenic genes in ovine corpus luteum during early pregnancy [PDF]

Eurasian Journal of Veterinary Sciences, 2021
Aim: The goal of this study was to investigate the expression of steroidogenic genes in ovine corpus luteum during early pregnancy. Materials and Methods: The animal model was designed as pregnancy; ewes were divided into three sub-groups, pregnancy 12th
Mustafa Hitit, Mehmet Köse, Bülent Bülbül, Nadir Koçak, Mehmet Osman Atlı   +4 more
doaj  

Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. [PDF]

PLoS ONE, 2011
Senescence, the state of permanent cell cycle arrest, has been associated with endothelial cell dysfunction and atherosclerosis. The cyclin dependent kinase inhibitors p21(CIP1/WAF1) and p16(INK4a) govern the G(1)/S cell cycle checkpoint and are ...
Josette M Douville, David Y C Cheung, Krista L Herbert, Teri Moffatt, Jeffrey T Wigle   +4 more
doaj   +1 more source

Cellular senescence and tumor suppressor gene p16 [PDF]

International Journal of Cancer, 2011
Abstract Cellular senescence is an irreversible arrest of cell growth. Biochemical and morphological changes occur during cellular senescence, including the formation of a unique cellular morphology such as flattened cytoplasm. Function of mitochondria, endoplasmic reticulum and lysosomes are affected resulting in the inhibition of ...
Hani, Rayess, Marilene B, Wang, Eri S, Srivatsan   +2 more
openaire   +2 more sources

Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).

PLoS ONE, 2020
Human papilloma virus (HPV) causes a subset of head and neck squamous cell carcinomas (HNSCC) of the oropharynx. We combined targeted DNA- and genome-wide RNA-sequencing to identify genetic variants and gene expression signatures respectively from ...
Nabil F Saba, Ashok R Dinasarapu, Kelly R Magliocca, Bhakti Dwivedi, Sandra Seby, Zhaohui S Qin, Mihir Patel, Christopher C Griffith, Xu Wang, Mark El-Deiry, Conor Ernst Steuer, Jeanne Kowalski, Dong Moon Shin, Michael E Zwick, Zhuo Georgia Chen   +14 more
doaj   +1 more source

Promoter Hypermethylation Profile of Tumour Suppressor Genes in Oral Leukoplakia and Oral Squamous Cell Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2014
Purpose of the Study: The present study was conducted to evaluate epigenetic alteration of five tumour suppressor genes in the oral precancer and cancer patients.
G. S. Asokan, S. Jeelani, N.Gnanasundaram   +2 more
doaj   +1 more source

Relation of the methylation state of RUNX3 and p16 gene promoters with hepatocellular carcinoma in Egyptian patients

Egyptian Journal of Medical Human Genetics, 2022
Background Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy of adults. RUNX3 and p16 are tumor suppressor genes that may be inactivated by hypermethylation which is a key epigenetic mechanism that contributes to the initiation
Fatma El-shaarawy, Mai M. Abo ElAzm, Rasha H. Mohamed, Mohamed I. Radwan, Dina M. Abo-Elmatty, Eman T. Mehanna   +5 more
doaj   +1 more source

Differential p16 expression levels in the liver, hepatocytes and hepatocellular cell lines [PDF]

PeerJ, 2021
Background One of the most frequently deleted genes in cancer is CDKN2A encoding p16. This protein is often overexpressed in senescent cells, while its suppression can bypass the oncogene-induced senescence to enable transformation and tumorigenesis. The
Barbara Kramar, Dušan Šuput, Irina Milisav   +2 more
doaj   +2 more sources