Results 161 to 170 of about 1,727,390 (297)

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

Insights Into the Interplay Between the Senescent Cells and Immune Cells. [PDF]

Aging Cell
Jaros M, Schmidt M, Neubert L, Kamp JC, von Vietinghoff S, Bräsen JH, Schmitt R, Melk A.   +7 more
europepmc   +1 more source

Hypermanganesemia in Children With Liver and Portosystemic Circulation Disorders: A Systematic Review

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim Children with chronic liver disease and portosystemic circulation disorders may have long‐term neurocognitive problems. Hypermanganesemia, reported in this group, could be a contributor. This systematic review aimed to characterise liver and portosystemic circulation disorders associated with hypermanganesemia and reported neurocognitive ...
Helena J. Kim, Susan M. Siew, Ji Hyun Moon, Tracey A. Williams, S. Murthy Chennapragada, Gordon Thomas, Shekeeb S. Mohammad   +6 more
wiley   +1 more source

[Corrigendum] The interaction between miR‑148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer. [PDF]

Oncol Rep
Hong L, Sun G, Peng L, Tu Y, Wan Z, Xiong H, Li Y, Xiao W.   +7 more
europepmc   +1 more source

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source

Comparative Analysis of Homo sapiens and Mus musculus Cyclin-Dependent Kinase (CDK) Inhibitor Genes P16 (MTSl) and PIS (MTS2)

, 1995
Cyclin-dependent kinase inhibitors are a growing family of molecules that regulate important transitions in the cell cycle. At least one of these molecules, p16, has been implicated in human tumorigenesis while its close homolog, p15, is induced by cell ...
Stone, Steven, Wold, Barbara J., Wagner, Roger, Wang, Susan L., Kozak, Christine A., Kamb, Alexander, Jiang, Ping, Dayananth, Priya   +7 more
core  

Prmt6 Deficiency Drives Osteoblast Senescence Promoting Age-Related Osteoporosis via Epigenetic Remodelling of the H3R2me2a/Sting/Ifitm3 Pathway. [PDF]

J Cell Mol Med
Wang Y, Ge X, Chang S, Wang D, Xu K, Xu H, Liu X, Wang S.   +7 more
europepmc   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence. [PDF]

Adv Sci (Weinh)
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Song J, Rindone AN, Guan Y, Amelung CD, Daswani PS, Elisseeff JH, Gerecht S.   +6 more
europepmc   +2 more sources

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source

Menopausal timing and senescent-immune coupling in age-related lobular involution of the human breast: a longitudinal cohort study. [PDF]

EBioMedicine
Lue JC, Stallings-Mann M, Hoskin T, McCauley BM, Vierkant RA, Pacheco-Spann L, Fischer JL, Gehling DL, Seymour LR, Baker DJ, Degnim AC, Winham SJ, Sherman ME, Radisky DC.   +13 more
europepmc   +1 more source