Results 171 to 180 of about 1,727,390 (297)

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

HPV16 E7-Associated SERPINB3 Suppression and MYC-Related Epithelial Plasticity in Head and Neck Squamous Cell Carcinoma. [PDF]

Cancers (Basel)
Liu Z, Zhang S, Liu T, Li Y, Li R, Liu H, Wang D, Tang Y, Ma H, Zhang Y, Wei L, Chu M.   +11 more
europepmc   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Targeting the senescence‒autophagy axis via p16^INK4a inhibition alleviates pulmonary fibrosis. [PDF]

Signal Transduct Target Ther
Yoo YJ, Zhang M, Jin SH, Lee YR, Jin H, Doan TP, Kim S, Choi S, Park EJ, Na S, Lee Y, Sun J, Cho J, Cho NC, Park SY, Oh WK, Lee YS.   +16 more
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

HMOX2-driven crosstalk between vascular aging and heart failure: A multimodal bioinformatics and explainable machine learning approach with experimental validation. [PDF]

PLoS One
Li J, Zhou G, Wang Q, Song Z, Liu J, Shen C, Luo C, Wang D.   +7 more
europepmc   +1 more source

Public perspectives on potential changes to malaria deferral criteria in Canada

Vox Sanguinis, EarlyView.
Abstract Background and Objectives As blood collection agencies (BCAs) seek to increase donor diversity, making changes to eligibility criteria to enable more people to donate is an important consideration. BCAs in Canada have a permanent deferral from whole blood and platelet donation for anyone with a history of malaria, a barrier to donation for ...
Courtney Joshua, Carmen Charlton, Joelle Kasongo, Biba Tinga, Jennie Haw   +4 more
wiley   +1 more source

Secreted protein combination GAPDH/S100A8/S100A9 from human expanded potential stem cells counteracts mesenchymal stromal cell senescence. [PDF]

Stem Cell Res Ther
Feng Q, Pang Q, Lu H, Liu Z, Lin Z, Songyang Z, Liu F, Shi G.   +7 more
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Senescence Markers and Associated Transcriptomic Changes Are Expressed at Early Stages of Alzheimer's Neuropathology but Are Not Independently Related to Dementia. [PDF]

Int J Mol Sci
Vazquez-Villaseñor I, Benson B, Richardson CD, Waller R, Castelli LM, Simpson JE, Matthews FE, Brayne C, Wharton SB, CFAS.   +9 more
europepmc   +1 more source