Results 241 to 250 of about 1,727,390 (297)

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, Volume 13, Issue 53, 24 September 2026.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Sodium butyrate attenuates D-galactose-induced cellular senescence in WI-38 fibroblasts <i>in vitro</i> via modulation of HDAC activity, Nrf2/ARE pathway, and p53/p21/p16 signaling. [PDF]

Front Physiol
Song K.
europepmc   +1 more source

Spatial Profiling Identified Senescent Cancer-Associated Fibroblasts Localized in the Border Region of Human Pancreatic Ductal Adenocarcinoma. [PDF]

Cell Mol Gastroenterol Hepatol
Harada Y, Masuda A, Matsuura T, Nagata K, Nanno Y, Masamune A, Kodama Y, Hara E, Matsumoto T.   +8 more
europepmc   +1 more source

MTR4 deficiency attenuates abdominal aortic aneurysm progression through suppressing VSMC senescence via the MTR4-RAP1a axis. [PDF]

iScience
Li Y, Tian K, Wang Y, Wu S, Cao Q, Wang S, Zhang X, Wang X, Lian H, Liu X, Hao Y, Wang W, Zhao L, Yu Q, Zhang L, Zhang Y, Wen J, Zheng B.   +17 more
europepmc   +1 more source

JMJD3-driven epigenetic reprogramming of p16^INK4a-positive cells promotes tendon regeneration. [PDF]

Bone Res
Liu X, Lu W, Wang Y, Zhang P, Su Z, Cao T, Zhang Y, Zhao J, Wang J, Xiang H, Huang W, Wang K, Pang S, Chen M, Li Y, Liu S.   +15 more
europepmc   +1 more source

Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation. [PDF]

Mater Today Bio
Luo J, Shao W, Liu S, Liang Z, Dong X, Xu S, Hou H, Zuo D, Zhou J.   +8 more
europepmc   +1 more source

Deletion of the p16 and p15 Genes in Human Bladder Tumors

JNCI Journal of the National Cancer Institute, 1995
Two genes, p16 (also known as CDKN2, INK4A, or MTS1) and p15 (also described as INK4B or MTS2), are found in tandem at chromosome 9p21. These genes are designated as candidate tumor suppressor genes because they encode proteins that function as negative cell cycle regulators. (The encoded polypeptides inactivate specific cyclin-protein kinase complexes
I, Orlow, L, Lacombe, G J, Hannon, M, Serrano, I, Pellicer, G, Dalbagni, V E, Reuter, Z F, Zhang, D, Beach, C, Cordon-Cardo   +9 more
openaire   +3 more sources