Results 221 to 230 of about 1,727,390 (297)

Prognostic Markers in Meningioma: Effectiveness of FISH‐Assessed CDKN2A/B Homozygous Deletion and Limits of Surrogate p16/MTAP Immunohistochemistry in Predicting Disease‐Specific Survival

Neuropathology and Applied Neurobiology, Volume 52, Issue 5, October 2026.
A cohort of 92 meningiomas was reclassified according to CNS WHO 2021. Diagnostic concordance between different CDKN2A/B homozygous deletion cutoffs assessed by FISH and MTAP/p16 immunohistochemistry was evaluated, with the aim to improve meningioma diagnostic workflow and prognostic estimation.
Alessia Andrea Ricci, Filippo Nozzoli, Alessandro Biale, Cristian Tampieri, Ludovica Verdun di Cantogno, Diego Garbossa, Mario Levis, Roberta Rudà, Camilla Bonaudo, Alessandro Della Puppa, Lorenzo Livi, Isacco Desideri, Paola Cassoni, Luca Bertero   +13 more
wiley   +1 more source

The cold case of state transition 7 (stt7) mutants of Chlamydomonas reinhardtii, solved by whole‐genome sequencing

New Phytologist, Volume 252, Issue 1, Page 145-162, October 2026.
Long‐read whole‐genome sequencing revealed extensive chromosomal rearrangements and aneuploidy in a widely used Chlamydomonas reinhardtii stt7‐1 mutant. The STT7 gene (shown in red) was found to be split between two rearranged chromosomes, providing a molecular explanation for the long‐standing failure of this mutant in genetic crosses.
Sandrine Bujaldon, Adrien Burlacot, Frédéric Chaux, Francis‐André Wollman   +3 more
wiley   +1 more source

AK050834 Deficiency Prevents Vascular Aging via Opposite Regulation of Two Senescence-Sensitive Genes ATF3 and p21. [PDF]

Aging Cell
Wu H, Yang P, Liu Y, Li Q, Wang X, Tang L, Li L, Huang T, Zhang X, Zhang C.   +9 more
europepmc   +1 more source

Disulfiram Attenuates Adenine‐Induced Renal Fibrosis by Modulating Inflammatory and Immunometabolic Responses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Chronic kidney disease (CKD) is characterized by persistent inflammation that drives progressive renal injury and fibrosis. In this study, we demonstrate that disulfiram markedly attenuates kidney injury and fibrosis in adenine‐induced nephropathy by suppressing innate immune responses and reducing DNA damage and cellular senescence.
Saori Kin, Yuji Oe, Shun Ishigaki, Ichiro Fujio, Mariko Miyazaki, Tetsuhiro Tanaka   +5 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, Volume 16, Issue 9, Page 1801-1812, September 2026.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Terpenoids as Emerging Senotherapeutics: Mechanistic Insights and Therapeutic Potential. [PDF]

Int J Mol Sci
Yi S, Park JY, Lee SJ.
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, Volume 7, Issue 3, Page 87-98, September 2026.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Histone demethylase KDM6B promotes postnatal oligodendrocyte maturation and cortical myelination. [PDF]

Front Cell Neurosci
Lambries R, Shen Z, Mias GI, He J.
europepmc   +1 more source

Cigarette Smoke‐Induced Alveolar Macrophage Senescence via GEM/SIRT3‐Mediated Mitochondrial Dysfunction

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Cigarette smoke accelerates the aging of immune cells in the lung. By combining human single‐cell sequencing, cell culture, and mouse models, the authors show that the protein GEM drives mitochondrial damage and senescence in alveolar macrophages by suppressing SIRT3.
Jin Wang, Meidan Wei, Xiangrong Song, Jiaxin Zhang, Lisha Zhang, Sixian Chen, Yaoyu Hu, Hui Gao, Jianxiang Li   +8 more
wiley   +1 more source

Cell-type resolved transcriptional network analysis of in vivo cellular senescence following injury. [PDF]

PLoS Comput Biol
Sabalic A, Moiseeva V, Cisneros A, Deryagin O, Perdiguero E, Muñoz-Cánoves P, Garcia-Ojalvo J.   +6 more
europepmc   +1 more source