Results 81 to 90 of about 599 (119)

Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma

Cancer, 2005
AbstractBACKGROUNDStepwise progression of peripheral‐type lung adenocarcinoma was characterized morphologically and was related to prognosis. Expression of the tumor suppressor gene p16 in pulmonary adenocarcinoma decreased, mainly as a result of aberrant methylation of the CpG islands of the promoter region.METHODSAberrant methylation status of the ...
Ryota, Tanaka, Daye, Wang, Yukio, Morishita, Yukinori, Inadome, Yuko, Minami, Tatsuo, Iijima, Shimao, Fukai, Tomoyuki, Goya, Masayuki, Noguchi   +8 more
openaire   +2 more sources

Hypermethylation of the p16 gene in normal oral mucosa of smokers

International Journal of Molecular Medicine, 2004
The oral cavity is the sixth most common anatomical localization of head and neck carcinoma in men. Detection of oral carcinomas in the early asymptomatic stages improves cure rates and the quality of life. Tobacco smoking and alcohol drinking are the most important known risk factors for the development of head and neck tumors, suggesting that the ...
S Ventorin, von Zeidler, E C, Miracca, M A, Nagai, E G, Birman   +3 more
openaire   +2 more sources

Deletion of the p16 and p15 Genes in Human Bladder Tumors

JNCI Journal of the National Cancer Institute, 1995
Two genes, p16 (also known as CDKN2, INK4A, or MTS1) and p15 (also described as INK4B or MTS2), are found in tandem at chromosome 9p21. These genes are designated as candidate tumor suppressor genes because they encode proteins that function as negative cell cycle regulators. (The encoded polypeptides inactivate specific cyclin-protein kinase complexes
I, Orlow, L, Lacombe, G J, Hannon, M, Serrano, I, Pellicer, G, Dalbagni, V E, Reuter, Z F, Zhang, D, Beach, C, Cordon-Cardo   +9 more
openaire   +2 more sources

Adenoviral p16/CDKN2 gene transfer to malignant glioma: Role of p16 in growth, invasion, and senescence

Oncology Reports, 2003
In gliomas, a high frequency of homozygous p16 gene deletions have been demonstrated, which are believed to be linked with malignant progression. The aim of this study was to assess the role of p16 in growth, invasion, and senescence. The human glioma cell lines U87 MG and U373 MG were transduced with Ad-p16, and cell viability was assessed by trypan ...
Seung-Ki, Kim, Kyu-Chang, Wang, Byung-Kyu, Cho, Su-Young, Lim, Young-Yim, Kim, Chang-Wan, Oh, You-Nam, Chung, Chae-Yong, Kim, Choon-Taek, Lee, Hyun Jib, Kim   +9 more
openaire   +2 more sources

Homozygous deletions of the CDKN2/p16 gene in dural hemangiopericytomas

Acta Neuropathologica, 1996
While most authors currently classify dural-based hemangiopericytoma (HPC) as a distinct entity rather than as a subtype of meningioma, the histogenesis of HPC has long been debated. We have recently shown that meningiomas contain frequent mutations of the neurofibromatosis 2 gene, while HPCs do not, suggesting that HPC is genetically distinct from ...
Y, Ono, K, Ueki, J T, Joseph, D N, Louis
openaire   +2 more sources

Mutations of the p16 gene product are rare in prostate cancer

The Prostate, 1997
The p16 gene product is a negative regulator of cell cycle and has been shown to be deleted or mutated in a number of tumor cell lines and primary tumors. The role of p16 in prostate cancer is not defined. Prostate cancer tissues and cell lines were evaluated for p16 gene alterations.Five metastatic prostate cancer cell lines were analyzed for p16 gene
J P, Gaddipati, D G, McLeod, I A, Sesterhenn, C J, Hussussian, Y A, Tong, P, Seth, N C, Dracopoli, J W, Moul, S, Srivastava   +8 more
openaire   +2 more sources

Deletion analysis of the p16 tumour suppressor gene in phaeochromocytomas

Clinical Endocrinology, 1996
SummaryBACKGROUND AND OBJECTIVES The molecular pathogenesis of phaeochromocytoma has not yet been fully established. The p16 turnour suppressor gene is often inactivated in a wide variety of primary human malignancies, including tumours of ectodermal origin.
R C, Aguiar, P L, Dahia, H, Sill, S P, Toledo, J M, Goldman, N C, Cross   +5 more
openaire   +2 more sources

Clinical Significance of P16 Gene Methylation in Lung Cancer

2020
Lung cancer is the leading cause of death from cancer in China. The lack of early screening technologies makes most patients to be diagnosed at advanced stages with a poor prognosis which often miss the best treatment opportunities. Thus, identifying biomarkers for minimally invasive detection and prognosis of early stage disease is urgently needed ...
Yanjun, Li, Tingting, Zhang, Hui, Zhang, Xiangdong, Wang, Xiaozhuan, Liu, Qihong, Huang, Li, Li   +6 more
openaire   +2 more sources

[Hypermethylation of CpG island of p16 gene and arsenic trioxide induced p16 gene demethylation in multiple myeloma].

Zhonghua nei ke za zhi, 2006
To investigate the role of hypermethylation of p16 gene in the pathogenesis of multiple myeloma (MM) and the effect of arsenic trioxide (As2O3) induced p16 gene demethylation.Methylation status of p16 gene in MM and U266 cell line exposed to As2O3 were detected the nested-methylation specific PCR.
Hai-ying, Fu, Jian-zhen, Shen
openaire   +1 more source

Mutational analysis of the p15 and p16 genes in acute leukaemias

British Journal of Haematology, 1996
Recently the p16 and related p15 genes have been described as candidate tumour suppressors at chromosome 9p21. These genes have been found to be homozygously deleted at a high frequency in several types of solid tumours and also in acute lymphoid leukaemias.
H, Sill, R C, Aguiar, H, Schmidt, A, Hochhaus, J M, Goldman, N C, Cross   +5 more
openaire   +2 more sources