Results 121 to 130 of about 1,681,356 (252)
Expression of p16 protein in breast cancer
Breast cancer is the most common cancer and a leading cause of death in women in Saudi Arabia. P16 is a tumour suppressor gene that plays a crucial role in regulating cell cycle.
Saad Samargandy +3 more
core +1 more source
Dasatinib and quercetin prevent alveolar bone loss in aged mice
Journal of Periodontology, EarlyView.Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli +7 more
wiley +1 more source
The Korean Journal of Gastroenterology, 2016 Background : /Aims: Helicobacter pylori infection induces aberrant DNA methylation in gastric mucosa. We evaluated the long-term effect of H. pylori eradication on promotor CpG island hypermethylation in gastric carcinogenesis. Methods : : H.
Jeongmin Choi +5 more
doaj +1 more source
Methylation and mutation analysis of p16 gene in gastric cancer
World Journal of Gastroenterology, 2003 To study methylation, frequencies of homozygous deletion and mutation of p16 gene in gastric carcinoma.The methylation pattern in exon 1 and exon 2 of p16 gene was studied with polymerase chain reaction (PCR), using methylation sensitive restriction endonuclease HpaII and methylation insensitive restriction endonuclease MspI.
Yi, Ding +3 more
openaire +2 more sources
Inactivation patterns of p16/INK4A in oral squamous cell carcinomas. [PDF]
, 2004 The p16/INK4A is one of the major target genes in carcinogenesis and its inactivation has frequently been reported in other types of tumors. The purpose of this study is to evaluate inactivation patterns of p16/INK4A in oral squamous cell carcinoma.
Kim, MJ +7 more
core +1 more source
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source
Methylation of p16 gene in hematological malignancies.
Chinese medical journal, 2001 To investigate the incidence of p16 gene methylation in hematological malignancies, and the relations between p16 gene methylation and the prognosis of hematological malignancies.Fifty-five patients were studied by restriction enzyme polymerase chain reaction (PCR) to detect p16 gene methylation.p16 gene methylation was detected in 6 of 55 patients (10.
W, Chen, J, Zhu, J, Liu, S, Tan
openaire +1 more source
Cloning and characterization of murine p16(INK4a) and p15(INK4b) genes
, 1995 Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-dependent kinases, cdk4 and cdk6. Genes encoding two specific inhibitors of these kinases, human p16((INK4a/MTS1)) and p15((INK4b/MTS2)) map to a region of ...
Quelle, D. E. +9 more
core
Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma
The Laryngoscope, EarlyView.We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano +3 more
wiley +1 more source
, 2013 In this study, methylation-specific polymerase chain reaction was used to investigate the role and potential prognostic significance of the methylation status of p16, p15, MGMT and DAPK genes in 32 specimens of follicular lymphoma (FL).
Krajnović, Milena M. +4 more
core +1 more source