Results 131 to 140 of about 1,681,356 (252)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, EarlyView.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

The role of p16 gene in oesophageal carcinoma

, 2012
published_or_final_version ; Medical Sciences ; Master ; Master of Medical ...
openaire   +2 more sources

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Investigation of Genetic Markers for Predicting Oral Cancer Progression and Patient Outcomes

Journal of Pharmacy and Bioallied Sciences
Background: Genomic methylation being used as a sensitive indicator for identifying oral potentially malignant disorders (OPMDS) and oral cancer could be a viable option.
Amit Wasti, Liza Mohanty, Ruchira Shukla, Bharti Gupta, Inderjit Murugendrappa Gowdar, Tarang Mehta, Ramanpal Singh Makkad   +6 more
doaj   +1 more source

Genetic alterations of chromosomes, p53 and p16 genes in low- and high-grade bladder cancer

, 2014
A majority of patients with bladder cancer present with superficial disease and subsequently, some patients show progression to muscle invasive or metastatic disease.
Demirhan O., Uslu I.N., Erdogan S., Abat D., Inandiklioglu N., Tunc E., Tastemir D.   +6 more
core   +1 more source

Differentiating high‐ and low‐grade serous ovarian carcinoma using radiomics: a pilot study

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To identify ultrasound‐based radiomics features capable of distinguishing between high‐grade serous ovarian carcinomas (HGSC) and invasive low‐grade serous ovarian carcinomas (LGSC), and to develop machine‐learning models that include radiomics features to discriminate between the two.
F. Ciccarone, G. Zinicola, E. H. Tran, G. Baldassari, E. Boccia, C. Nero, F. Moro, T. Pasciuto, G. Scambia, G. Ferrandina, A. Fagotti, A. C. Testa, D. Lorusso, Collaborators, F. Borella, F. Buonomo, R. Fruscio, F. Pozzati   +17 more
wiley   +1 more source

P16-positive senescent cells promote DKD by the dysregulation of glycolysis and mitochondrial metabolism

Cell Death Discovery
Diabetic kidney disease (DKD) is characterized by kidney damage and abnormal renal energy metabolism, but the molecular mechanism of DKD is still unclear.
Xiao Lu, Jiao Wu, Ewud Agborbesong, Xiaogang Li   +3 more
doaj   +1 more source

Local Low‐Frequency Vibration Enhances Wound‐Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model

The Journal of Dermatology, EarlyView.
ABSTRACT Hard‐to‐heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence‐associated mechanisms, including stress‐responsive p53/p21 signaling and senescence‐associated secretory phenotype‐related inflammation, contribute to impaired wound ...
Daijiro Haba, Chihiro Takizawa, Qi Qin, Sanai Tomida, Ai Horinouchi, Hiromi Sanada, Gojiro Nakagami   +6 more
wiley   +1 more source