Results 211 to 220 of about 1,681,356 (252)

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, Volume 270, Issue 1, Page 23-39, September 2026.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

The Journal of Pathology, Volume 270, Issue 1, Page 4-22, September 2026.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends   +5 more
wiley   +1 more source

Injectable Zein‐Based Photothermal Composite Hydrogel Enhances Osteoporotic Tendon–Bone Healing

Small Methods, Volume 10, Issue 17, 9 September 2026.
Schematic illustration of the Zein‐based, dopamine‐grafted, niacin‐loaded carbon nanosphere (ZDC) composite hydrogel for enhancing healing of osteoporotic rotator cuff tears. This electron beam‐modified composite hydrogel is designed for NIR‐responsive release of niacin, which alleviates inflammation, promotes angiogenesis, and facilitates the ...
Kai Ye, Peng Ding, Zhenyou Dong, Wenyan Shi, Longxiang Shen, Xianyou Zheng   +5 more
wiley   +1 more source

Industry perceptions of biological control in food manufacturing environments: A qualitative analysis of barriers and opportunities

Annals of Applied Biology, Volume 189, Issue 2, September 2026.
Biological control is widely used in agriculture but rarely deployed in food manufacturing, where industry acceptability is unexamined. Semi‐structured interviews with 17 food manufacturing professionals across 15 facility contexts in northwest England and north Wales explored views on entomopathogenic fungi, Bacillus thuringiensis and parasitoid wasps.
Bethany Hadfield, Ben J. Clunie, Tom W. Pope, Joe M. Roberts   +3 more
wiley   +1 more source

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Study on P16 gene in acute leukemia

Current Medical Science, 2000
To study the change of suppressing cancer gene P16 in acute leukemia, the P16 antigen expression of leukemia cell surfaces in 61 cases were investigated with ABC assay and gene structural defects in 51 cases of acute leukemia were examined with multiple comparative PCR method.
Y, Chen, H, Zhang, B, Yue, H, Li
openaire   +2 more sources

Alterations of the p15, p16, and p18 genes in osteosarcoma

Cancer Genetics and Cytogenetics, 1996
Activation of cyclin-dependent kinases (CDKs) by interaction with cyclins regulates progression through cell cycle checkpoints. This process is counterbalanced by CDK inhibitors (CDKIs), which can inhibit progression through the cell cycle. Because CDKI expression acts to inhibit cellular proliferation, CDKIs may have a role as tumor suppressors.
C W, Miller, A, Aslo, M J, Campbell, N, Kawamata, B C, Lampkin, H P, Koeffler   +5 more
openaire   +2 more sources

Adenovirus p16 gene therapy for prostate cancer

World Journal of Urology, 2000
Surgery, radiation, or hormone deprivation alone does not adequately affect local control of clinical or pathologic stage T3 prostate cancer. Lack of local cancer control ultimately leads to a higher incidence of morbidity, distant metastasis, and decreased survival, with patients having disease-specific mortality exceeding 75%.
J A, Allay, M S, Steiner, Y, Zhang, C P, Reed, J, Cockroft, Y, Lu   +5 more
openaire   +2 more sources

p16 gene overexpression in mouse bladder carcinomas

Cancer Letters, 1998
Deletion of 9p21 has frequently been observed in human bladder carcinomas. A candidate target suppressor gene, p16, was recently identified within this deleted region. In this study, we therefore investigated the loss of heterozygosity (LOH) of the p16 gene which is located on mouse chromosome 4, as well as its expression in mouse bladder carcinomas ...
M, Asamoto, T, Hori, H, Baba-Toriyama, M, Sano, S, Takahashi, H, Tsuda, T, Shirai   +6 more
openaire   +2 more sources

Decreased expression of p16 gene in gastric cancer

International Journal of Oncology, 1996
We analyzed gastric cancers for p16 gene alterations. Homozygous deletion of the p16 gene was found in 1 of 8 gastric cancer cell lines and none of 20 primary gastric cancers. Mutations of the p16 gene were not detected in exon 1-3. Reverse transcription-polymerase chain reaction (RT-PCR) analysis showed decreased or no expression of the p16 gene in 1 ...
S, Fushida, Y, Yonemura, H, Takamura, Y, Hirono, I, Miyazaki, T, Urano   +5 more
openaire   +2 more sources

Mutational analysis of the p16 gene in human neuroblastomas

Molecular Carcinogenesis, 1997
Neuroblastoma is one of the most frequent tumors in infancy. We analyzed 26 neuroblastomas, two ganglioneuromas, and a neuroblastoma metastasis for mutations and homozygous deletions of the p16 (or MTS1 or CDKN2) gene by means of the polymerase chain reaction (PCR) in combination with the single-strand conformation polymorphism (SSCP) technique and by ...
J S, Castresana, L, Gómez, P, García-Miguel, A, Queizán, A, Pestaña   +4 more
openaire   +2 more sources