Results 221 to 230 of about 1,681,356 (252)

Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues

International Journal of Cancer, 2000
The role of two important tumour suppressor genes, p16 and p53, was evaluated in cartilaginous tumour tissues. Genomic DNA from 22 chondrosarcomas, 5 benign chondroid tumours, 1 sample of reactive proliferative cartilage and 2 samples of normal cartilage were analysed using polymerase chain reaction, single strand conformational polymorphism, DNA ...
J, Asp, L, Sangiorgi, S E, Inerot, A, Lindahl, L, Molendini, M S, Benassi, P, Picci   +6 more
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Inactivation of the p16 Tumor Suppressor Gene in Adrenocortical Tumors

Journal of Clinical Endocrinology & Metabolism, 1999
The mechanisms of adrenocortical tumorigenesis are still unknown. Evidence that the majority of adrenocortical tumors are monoclonal in origin suggests that a progressive accumulation of genetic aberrations, due to activation of protooncogenes and/or inactivation of tumor suppressor genes, leads to abnormal cell proliferation through a multistep ...
PILON C, PISTORELLO M, MOSCON A, ALTAVILLA, GIUSEPPE, PAGOTTO U, BOSCARO, MARCO, FALLO, FRANCESCO   +6 more
openaire   +3 more sources

Hypermethylation of the p16 gene in nasopharyngeal carcinoma.

Cancer research, 1996
We have recently reported that inactivation of the p16 gene by mutation and deletion is common in nasopharyngeal carcinoma (NPC). The present study demonstrates that hypermethylation of the 5' CpG island can serve as an alternative mechanism for inactivation of the p16 gene in this tumor.
Chung, YF, Lee, JCK, Lo, KW, Cheung, ST, Leung, SF, Van Hasselt, A, Tsang, YS, Mak, KF, Woo, JKS, Huang, DP   +9 more
openaire   +2 more sources

[Effects of inorganic arsenicals on the methylation of p16 gene CpG islands and the expression of p16 gene in BEP2D cells].

Zhonghua yi xue za zhi, 2002
To study the effects of inorganic arsenicals on the methylation of p16 gene CpG islands and the expression of p16 gene in BEP2D cells.The methylation of p16 gene CpG islands and the expression of p16 gene in BEP2D cells were measured by methylation-specific PCR (MSP) and RT-PCR methods.(1) The exposure of the BEP2D cells to sodium arsenite (0.016 ...
G, Lu, Q, Cai, W, Zhang
openaire   +1 more source

p16 gene alterations in nasopharyngeal carcinoma.

Cancer research, 1995
In order to investigate the p16 gene alterations in nasopharyngeal carcinoma (NPC), we have examined for mutations and deletions of the p16 gene in samples of NPC including 3 cell lines, 3 xenografts, and 20 primary tumors with matched blood DNA as controls.
K W, Lo, D P, Huang, K M, Lau
openaire   +1 more source

[Alterations of the p16 gene for the carcinogenesis in pancreas].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2004
Pancreatic cancer is a common malignant neoplasm in digestive tract, which is of unknown etiology as yet. Recent advances in molecular oncology have provided explanations at the DNA level that multiple genetic changes contribute to pancreatic cancer development, in which the p16 locus of tumor tissue is nearly always altered. This tumor suppressor gene,
C, Wang, X, Lu
openaire   +1 more source

[A study on the inactivation of p16 genes and the expression of P16 protein in primary hepatocellular carcinomas].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 2003
The aim of the present study was to determine whether p16 gene is involved in the genesis of primary hepatocellular carcinoma (HCC). Twenty-five primary HCC tumor and corresponding non-tumor liver tissue specimens were examined for P16 gene alterations.
J, Huang, W, Shen, B, Li, Y, Luo, S, Liao, W, Zhang, N, Cheng   +6 more
openaire   +1 more source

Quantitative Determination of p16 Gene Expression by RT-PCR

2004
In recent years, gene expression quantitation of tumor cells has become of principal importance to analyze gene patterns responsible for cancer development, progression, and resistance to treatment. Whereas semi-quantitative methods, such as Northern blotting analysis, allow only a dichotomous differentiation between positive and negative gene ...
Sylke, Schneider, Kazumi, Uchida, Dennis, Salonga, Ji Min, Yochim, Kathleen D, Danenberg, Peter V, Danenberg   +5 more
openaire   +2 more sources

P16 gene in uncultured tumours

Nature, 1994
C H, Spruck, M, Gonzalez-Zulueta, A, Shibata, A R, Simoneau, M F, Lin, F, Gonzales, Y C, Tsai, P A, Jones   +7 more
openaire   +2 more sources

[Function of p16 gene and correlation of p16 with human cancer].

Sheng li ke xue jin zhan [Progress in physiology], 1998
M, Sun, Y Y, Lu
openaire   +1 more source