Results 41 to 50 of about 373,131 (211)

Extracranial Vascular Anomalies Driven by RAS/MAPK Variants: Spectrum and Genotype–Phenotype Correlations

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to correlate alterations in the rat sarcoma virus (RAS)/mitogen‐activated protein kinase pathway in vascular anomalies to the clinical phenotype for improved patient and treatment stratification. Methods and Results This retrospective
Vanessa F. Schmidt, Friedrich G. Kapp, Constantin Goldann, Linda Huthmann, Beatrix Cucuruz, Richard Brill, Veronika Vielsmeier, Caroline T. Seebauer, Armin‐Johannes Michel, Max Seidensticker, Wibke Uller, Jakob B. W. Weiß, Alena Sint, Beate Häberle, Julia Haehl, Alexandra Wagner, Johanna Cordes, Annegret Holm, Denny Schanze, Jens Ricke, Melanie A. Kimm, Walter A. Wohlgemuth, Martin Zenker, Moritz Wildgruber   +23 more
doaj   +1 more source

Transient disappearance of RAS mutant clones in plasma: A counterintuitive clinical use of EGFR inhibitors in RAS mutant metastatic colorectal cancer [PDF]

, 2019
Genomic studies performed through liquid biopsies widely elucidated the evolutionary trajectory of RAS mutant clones under the selective pressure of EGFR inhibitors in patients with wild type RAS primary colorectal tumors. Similarly, the disappearance of
Belardinilli, Francesca, Cortesi, Enrico, Gazzaniga, Paola, Gelibter, ALAIN JONATHAN, Giannini, Giuseppe, Gradilone, Angela, Loreni, Flavia, Mahdavia, Yasaman, Nicolazzo, Chiara, Raimondi, Cristina   +9 more
core   +1 more source

Alterations in gene expression associated with invasion of RAS-mutant thyroid tumors and their potential diagnostic and therapeutic utility

European Thyroid Journal
Introduction: Mutations of RAS genes are detected in a spectrum of follicular-patterned thyroid tumors. Preoperative prediction of invasive cancers based on the presence of RAS mutation alone is challenging because non-invasive and invasive tumors tend ...
Vincenzo Condello, William R Doerfler, Alyaksandr V Nikitski, Daniel M Spagnolo, Ian J Fornal, Gavin M Schmidt, Abigail I Wald, Marina N Nikiforova, Yuri E Nikiforov   +8 more
doaj   +1 more source

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells

Cell Reports, 2017
Activating mutations in the KRAS oncogene are highly prevalent in tumors, especially those of the colon, lung, and pancreas. To better understand the genetic dependencies that K-Ras mutant cells rely upon for their growth, we employed whole-genome CRISPR
Timothy D. Martin, Danielle R. Cook, Mei Yuk Choi, Mamie Z. Li, Kevin M. Haigis, Stephen J. Elledge   +5 more
doaj   +1 more source

RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases. [PDF]

, 2013
ObjectiveTo determine the impact of RAS mutation status on survival and patterns of recurrence in patients undergoing curative resection of colorectal liver metastases (CLM) after preoperative modern chemotherapy.BackgroundRAS mutation has been reported ...
Aloia, Thomas A, Andreou, Andreas, Chen, Su S, Curley, Steven A, Kopetz, Scott E, Maru, Dipen M, Shindoh, Junichi, Vauthey, Jean-Nicolas, Zimmitti, Giuseppe   +8 more
core   +1 more source

Ras Genes in Human Breast Cancer [PDF]

Disease Markers, 1999
The expression of ras mRNA levels in 27 human sporadic breast cancer specimens was examined, and compared to the corresponding adjacent normal tissue using the RT-PCR technique. Eighteen out of the 27 specimens (67%) exhibited twoto four-fold increased expression of ras mRNA levels, compared to corresponding normal tissue.
Miyakis, Spiros, Sourvinos, George, Spandidos, Demetrios A.   +2 more
openaire   +1 more source

Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway

BMC Cancer, 2009
Background Overexpression of Aurora-A and mutant Ras (RasV12) together has been detected in human bladder cancer tissue. However, it is not clear whether this phenomenon is a general event or not.
Huang Chi-Ying F, Lee Jenq-Chang, Tseng Ya-Shih, Liu Hsiao-Sheng   +3 more
doaj   +1 more source

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations

Scientific Reports
In cancer research, RAS biology has been focused on only a handful of tumor types. While RAS genes have long been suspected as common contributors to a wide spectrum of cancer types, robust evidence is required to firmly establish their critical ...
Ming Yi, Daniel Soppet, Frank McCormick, Dwight V. Nissley   +3 more
doaj   +1 more source

EXPRESIÓN DE LAS PROTEÍNAS p21 RAS y CÁNCER

Medicentro, 2011
Los genes ras pertenecen a una superfamilia de genes que codifican pequeñas proteínas de unión a nucleótidos de guanina. Las proteínas p21 Ras se localizan en la superficie interna de la membrana celular, donde actúan como interruptores moleculares ...
Otmara Guirado Blanco
doaj  

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source