Results 51 to 60 of about 373,131 (211)
A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]
, 2020 The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan +11 more
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Activated ras genes in pulmonary carcinoma
Lung Cancer, 1988 Peer ...
Almoguera, Concepción +4 more
openaire +2 more sources
Medicentro, 2017 Los genes ras pertenecen a una superfamilia de genes que codifican pequeñas proteínas de unión a nucleótidos de guanina. Las proteínas p21 Ras se localizan en la superficie interna de la membrana celular, donde actúan como interruptores moleculares ...
Otmara Guirado Blanco +1 more
doaj
PLoS Genetics, 2011 Cellular senescence involves epigenetic alteration, e.g. loss of H3K27me3 in Ink4a-Arf locus. Using mouse embryonic fibroblast (MEF), we here analyzed transcription and epigenetic alteration during Ras-induced senescence on genome-wide scale by chromatin
Atsushi Kaneda +9 more
doaj +1 more source
Global gene analysis identifying genes commonly regulated by the Ras/Raf/MEK and type I IFN pathways
Genomics Data, 2015 Oncolytic viruses exploit alterations in cancer cells to specifically infect cancer cells but not normal healthy cells. Previous work has shown that oncogenic Ras interferes with interferon (IFN) signaling to promote viral replication.
Y. Komatsu, K. Hirasawa, S.L. Christian
doaj +1 more source
Mutations of ras genes in human tumours (Review) [PDF]
, 2008 Journal URL: http://www.spandidos-publications.com/ijo/Ras family genes (H-, K- and N-ras) are implicated in a wide range of human tumours. Mutations are a major activating mechanism for the ras family genes, mainly in codons 12, 13 and 61, resulting in ...
Kiaris, H., Spandidos, D. A.
core
Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]
, 2019 Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A +4 more
core +1 more source
Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer
Scientific Reports, 2018 Hyperactivation of Wnt and Ras-MAPK signalling are common events in development of colorectal adenomas. Further progression from adenoma-to-carcinoma is frequently associated with 20q gain and overexpression of Aurora kinase A (AURKA).
Annika Jacobsen +11 more
doaj +1 more source
Molecular Cancer, 2003 Background Ras is an area of intensive biochemical and genetic studies and characterizing downstream components that relay ras-induced signals is clearly important.
Berthezene Patrice +6 more
doaj +1 more source
Targeting RAS mutants in malignancies: successes, failures, and reasons for hope
Cancer Communications, 2023 RAS genes are the most frequently mutated oncogenes and play critical roles in the development and progression of malignancies. The mutation, isoform (KRAS, HRAS, and NRAS), position, and type of substitution vary depending on the tissue types.
Hang Yang +9 more
doaj +1 more source