Results 41 to 50 of about 1,074,410 (298)

Identification of a prognosis-related phagocytosis regulator gene signature in medulloblastoma

Heliyon
Objectives: The aims of this study were to screen for phagocytosis regulator-related genes in tissue samples from children with medulloblastoma (MB) and to construct a prognostic model based on those genes. Methods: Differentially expressed genes between
Guoqing Han, Xingdong Wang, Ke Pu, Zhenhang Li, Qingguo Li, Xiaoguang Tong   +5 more
doaj   +1 more source

NFIX as a Master Regulator for Lung Cancer Progression

Frontiers in Pharmacology, 2017
About 40% of lung cancer cases globally are diagnosed at the advanced stage. Lung cancer has a high mortality and overall survival in stage I disease is only 70%.
Nor I. A. Rahman, Nor A. Abdul Murad, Mohammad M. Mollah, Rahman Jamal, Rahman Jamal, Roslan Harun, Roslan Harun   +6 more
doaj   +1 more source

YhjC is a novel transcriptional regulator required for Shigella flexneri virulence

Virulence, 2021
Shigella is an intracellular pathogen that primarily infects the human colon and causes shigellosis. Shigella virulence relies largely on the type III secretion system (T3SS) and secreted effectors.
Wanwu Li, Lingyan Jiang, Xiaoqian Liu, Rui Guo, Shuai Ma, Jingting Wang, Shuangshuang Ma, Shujie Li, Huiying Li   +8 more
doaj   +1 more source

Transcriptome and metabolome profiling to elucidate the mechanism underlying the poor growth of Streptococcus suis serotype 2 after orphan response regulator CovR deletion

Frontiers in Veterinary Science, 2023
The deletion of orphan response regulator CovR reduces the growth rate of Streptococcus suis serotype 2 (S. suis 2). In this study, metabolome and transcriptome profiling were performed to study the mechanisms underlying the poor growth of S.
Bingbing Zong, Yong Xiao, Rui Li, Huanhuan Li, Peiyi Wang, Xiaopei Yang, Yanyan Zhang   +6 more
doaj   +1 more source

Dietary soy and meat proteins induce distinct physiological and gene expression changes in rats [PDF]

, 2016
This study reports on a comprehensive comparison of the effects of soy and meat proteins given at the recommended level on physiological markers of metabolic syndrome and the hepatic transcriptome.
A Hagiwara, A Lass, A Shukla, A Subramanian, AM Uhe, B He, BB Albert, C Brandsch, C Chaveroux, CJ Andersen, CW Law, D Eberle, D El Khoury, D Gaidatzis, D Karolchik, D Merico, D Ord, D Tome, DW Gietzen, E Tornberg, G Fromentin, G Sarwar, H Sidransky, HX Yuan, J Cacho, J Schwarz, JI Lee, JL Jewell, JM Beasley, KK Carroll, L Abatangelo, L Noriega-Lopez, LE Matarese, M Friedman, M Shimobayashi, MD Robinson, MD Robinson, ME Ritchie, ML Orgeron, MS Kilberg, N Tachibana, PG Reeves, PM Leung, PM Pereira, R Bourgon, R Hoffenberg, R Hosomi, S Guo, S Madani, S Wen, SM Potter, SN Twigger, T Berry, TG Anthony, V Ranawana, W Gade, W Kang, Y Takahashi   +57 more
core   +2 more sources

Contextual Refinement of Regulatory Targets Reveals Effects on Breast Cancer Prognosis of the Regulome. [PDF]

PLoS Computational Biology, 2017
Gene expression regulators, such as transcription factors (TFs) and microRNAs (miRNAs), have varying regulatory targets based on the tissue and physiological state (context) within which they are expressed. While the emergence of regulator-characterizing
Erik Andrews, Yue Wang, Tian Xia, Wenqing Cheng, Chao Cheng   +4 more
doaj   +1 more source

Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in Streptomyces malaysiensis F913

Antibiotics, 2022
Nigericin is a polyether antibiotic with potent antibacterial, antifungal, antimalarial and anticancer activity. NigR, the only regulator in the nigericin biosynthetic gene cluster in Streptomyces malaysiensis F913, was identified as a SARP family ...
Junhong Wei, Mengting Ma, Senwen Guo, Yaobo Xu, Jie Xie, Guoqing Pan, Zeyang Zhou   +6 more
doaj   +1 more source

Detection of regulator genes and eQTLs in gene networks

, 2016
Genetic differences between individuals associated to quantitative phenotypic traits, including disease states, are usually found in non-coding genomic regions.
A Butte, A Chatr-Aryamontri, A Clauset, A Joshi, A Joshi, A Kundaje, AA Shabalin, AJ Enright, AJ Walhout, AS Dimas, B Schwanhausser, B Zhang, B Zhang, C Cenik, CO Daub, D Koller, DA Cusanovich, DM Greenawalt, E Bonnet, E Ravasz, E Segal, EC Neto, EC Neto, EC Neto, EE Schadt, EE Schadt, EE Schadt, EE Schadt, EE Schadt, EJ Foss, F Grubert, F Yue, FA Cubillos, FW Albert, G Hemani, G Nicholson, GD Smith, GH Golub, H Foroughi Asl, H Talukdar, HN Kadarmideen, J Millstein, J Qi, J Zhu, J Zhu, J Zhu, JE Aten, JF Ayroles, JJ Faith, JL Björkegren, JS Liu, K Basso, K Qu, KG Ardlie, L Wu, LA Hindorff, LH Hartwell, LS Chen, M Ashburner, M Civelek, M Georges, M Gerstein, M Medvedovic, M Schmidt, M Scutari, MA Schaub, MB Eisen, MD Ritchie, ME Goddard, MEJ Newman, MEJ Newman, MV Rockman, MV Rockman, N Friedman, N Friedman, N Friedman, N Laird, O Stegle, P Langfelder, P Langfelder, P Langfelder, P Lu, R Sharan, R Sharan, RB Brem, RW Williams, S Lee, S Roy, S Tavazoie, SI Lee, SM Waszak, SS Rao, T Lappalainen, T Michoel, TA Manolio, TF Mackay, The ENCODE, TS Furey, VG Cheung, W Cookson, W Zhang, Y Chen, Y Li   +102 more
core   +1 more source

Genome-Wide Analysis of Glycine soja Response Regulator GsRR Genes Under Alkali and Salt Stresses

Frontiers in Plant Science, 2018
Soil salt-alkalization is a dramatic challenging factor for plant growth. Wild soybean (Glycine soja) exhibits a favorable trait of superior tolerance to salt-alkali stress, and recent discoveries show that response regulator family genes are involved in
Chao Chen, Ailin Liu, Hao Ren, Yang Yu, Huizi Duanmu, Xiangbo Duan, Xiaoli Sun, Beidong Liu, Yanming Zhu   +8 more
doaj   +1 more source

The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica.

PLoS Genetics, 2020
To survive an environmental stress, organisms must detect the stress and mount an appropriate response. One way that bacteria do so is by phosphorelay systems that respond to a stress by activating a regulator that modifies gene expression.
Hubert Salvail, Eduardo A Groisman
doaj   +1 more source