Results 51 to 60 of about 759,014 (317)

Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]

, 2010
Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.
Peter F. Zipfel, Dam, A.P. van, Schuijt, Tim J., Kraiczy, Peter, Nathalie D. van Burgel, Nathalie D. van Burgel, van Dam, Alje P., van Burgel Nathalie D, Burgel, N.D. van, Burgel, Nathalie D. van, Schuijt Tim J, Tim J. Schuijt, Kraiczy Peter, Schuijt, T.J., van Dam Alje P, Zipfel Peter F, Kraiczy, P., Zipfel, Peter F., Alje P. van Dam, Peter Kraiczy, Zipfel, P.F., Dam, Alje P. van, van Burgel, Nathalie D.   +22 more
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

The Zur regulon of Corynebacterium glutamicum ATCC 13032

, 2010
Schröder J, Jochmann N, Rodionov DA, Tauch A. The Zur regulon of Corynebacterium glutamicum ATCC 13032. BMC Genomics. 2010;11(1): 12.Background Zinc is considered as an essential element for all living organisms, but it can be toxic at large ...
Schröder Jasmin, Andreas Tauch, Tauch Andreas, Jochmann, Nina, Jasmin Schröder, Nina Jochmann, Tauch, Andreas, Dmitry A Rodionov, Schröder, Jasmin, Rodionov, Dmitry A., Rodionov Dmitry A, Jochmann Nina   +11 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Integrated regulation of the type III secretion system and other virulence determinants in Ralstonia solanacearum

, 2006
In many plant and animal bacterial pathogens, the Type III secretion system (TTSS) that directly translocates effector proteins into the eukaryotic host cells is essential for the development of disease.
Christian Boucher, Valls Marc, Valls i Matheu, Marc, Marc Valls, Boucher, Christian, Genin Stéphane, Genin, S., Boucher Christian, Stéphane Genin   +8 more
core   +1 more source

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. [PDF]

, 2007
The Mycobacterium tuberculosis TetR-type regulator Rv3574 has been implicated in pathogenesis as it is induced in vivo, and genome-wide essentiality studies show it is required for infection.
Withers, Mike, Moreland, NJ, Sidders, B, Ben Sidders, Catherine N. Soffair, Besra, Gurdyal; id_orcid, ten Bokum, A, Ten Bokum, A M C, Kendall, Sharon L, Soffair, CN, Sudagar Gurcha, Stoker, NG, Rosangela Frita, Gurdyal S. Besra, Besra, G S, Moreland, Nicole J, Moreland, N J, Kendall, SL, J. Shaun Lott, Sidders, Ben, Frita, R, Soffair, Catherine N, Neil G. Stoker, Frita, Rosangela, Soffair, C N, Mike Withers, Gurcha, S, Stoker, N G, Nicole J. Moreland, Auckland, Sydney, Birmingham, Gurcha, Sudagar, Sharon L. Kendall, Lott, J Shaun, Kendall, S L, Stoker, Neil G, Lott, J S, Ten Bokum, Annemieke, Withers, M, Lott, JS, Annemieke Ten Bokum, Besra, Gurdyal S   +41 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]

, 2004
The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Lin, J., Jaeger, S., Tempst, P., Puigserver, P., Fan, M., Handschin, C., St-Pierre, J., Spiegelman, B. M., Rhee, J., Erdjument-Bromage, H.   +9 more
core   +1 more source

Specificity of Gene Regulation [PDF]

Cell, 2002
The physiologically coordinated expression of our genome requires exquisite regulation of gene specificity. Recent advances demonstrate that this formidable task is accomplished by diverse mechanisms and networks that operate at distinct levels within the nucleus.
openaire   +2 more sources

Gene Regulation and Speciation [PDF]

Trends in Genetics, 2017
Understanding the genetic architecture of speciation is a major goal in evolutionary biology. Hybrid dysfunction is thought to arise most commonly through negative interactions between alleles at two or more loci. Divergence between interacting regulatory elements that affect gene expression (i.e., regulatory divergence) may be a common route for these
Mack, Katya L, Nachman, Michael W
openaire   +4 more sources