Results 51 to 60 of about 2,777,748 (307)

Outer membrane protein genes and their small non-coding RNA regulator genes in Photorhabdus luminescens

Biology Direct, 2006
Introduction Three major outer membrane protein genes of Escherichia coli, ompF, ompC, and ompA respond to stress factors. Transcripts from these genes are regulated by the small non-coding RNAs micF, micC, and micA, respectively.
Delihas Nicholas, Papamichail Dimitris
doaj   +1 more source

Contextual Refinement of Regulatory Targets Reveals Effects on Breast Cancer Prognosis of the Regulome. [PDF]

PLoS Computational Biology, 2017
Gene expression regulators, such as transcription factors (TFs) and microRNAs (miRNAs), have varying regulatory targets based on the tissue and physiological state (context) within which they are expressed. While the emergence of regulator-characterizing
Erik Andrews, Yue Wang, Tian Xia, Wenqing Cheng, Chao Cheng   +4 more
doaj   +1 more source

Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in Streptomyces malaysiensis F913

Antibiotics, 2022
Nigericin is a polyether antibiotic with potent antibacterial, antifungal, antimalarial and anticancer activity. NigR, the only regulator in the nigericin biosynthetic gene cluster in Streptomyces malaysiensis F913, was identified as a SARP family ...
Junhong Wei, Mengting Ma, Senwen Guo, Yaobo Xu, Jie Xie, Guoqing Pan, Zeyang Zhou   +6 more
doaj   +1 more source

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. [PDF]

, 2007
The Mycobacterium tuberculosis TetR-type regulator Rv3574 has been implicated in pathogenesis as it is induced in vivo, and genome-wide essentiality studies show it is required for infection.
Withers, Mike, Moreland, NJ, Sidders, B, Ben Sidders, Catherine N. Soffair, Besra, Gurdyal; id_orcid, ten Bokum, A, Ten Bokum, A M C, Kendall, Sharon L, Soffair, CN, Sudagar Gurcha, Stoker, NG, Rosangela Frita, Gurdyal S. Besra, Besra, G S, Moreland, Nicole J, Moreland, N J, Kendall, SL, J. Shaun Lott, Sidders, Ben, Frita, R, Soffair, Catherine N, Neil G. Stoker, Frita, Rosangela, Soffair, C N, Mike Withers, Gurcha, S, Stoker, N G, Nicole J. Moreland, Gurcha, Sudagar, Sharon L. Kendall, Lott, J Shaun, Kendall, S L, Stoker, Neil G, Lott, J S, Ten Bokum, Annemieke, Withers, M, Lott, JS, Annemieke Ten Bokum, Besra, Gurdyal S   +39 more
core   +1 more source

Genome-Wide Analysis of Glycine soja Response Regulator GsRR Genes Under Alkali and Salt Stresses

Frontiers in Plant Science, 2018
Soil salt-alkalization is a dramatic challenging factor for plant growth. Wild soybean (Glycine soja) exhibits a favorable trait of superior tolerance to salt-alkali stress, and recent discoveries show that response regulator family genes are involved in
Chao Chen, Ailin Liu, Hao Ren, Yang Yu, Huizi Duanmu, Xiangbo Duan, Xiaoli Sun, Beidong Liu, Yanming Zhu   +8 more
doaj   +1 more source

Specificity of Gene Regulation [PDF]

Cell, 2002
The physiologically coordinated expression of our genome requires exquisite regulation of gene specificity. Recent advances demonstrate that this formidable task is accomplished by diverse mechanisms and networks that operate at distinct levels within the nucleus.
openaire   +2 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Expression profiles of Caspase and Caspase Regulator Genes.

, 2016
Expression profiles of Caspase and Caspase Regulator Genes.
Nicoleta Cehan (843504), Laura Ulitzky (248632), Livia Alves Lima (2826206), Deborah R. Taylor (248652), Erica Silberstein (248622), Andréa Teixeira-Carvalho (1805704), Philippe Roingeard (35330)   +6 more
core   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Improving gene set enrichment analysis (GSEA) by using regulation directionality

Microbiology Spectrum
To infer the biological meaning from transcriptome data, it is useful to focus on genes that are regulated by the same regulator, i.e., regulons. Unfortunately, current gene set enrichment analysis (GSEA) tools do not consider whether a gene is activated
Biwen Wang, Frans van der Kloet, Mariah B. M. J. Kes, Joen Luirink, Leendert W. Hamoen   +4 more
doaj   +1 more source