Results 31 to 40 of about 759,014 (317)

Causal inference of regulator-target pairs by gene mapping of expression phenotypes

BMC Genomics, 2006
Background Correlations between polymorphic markers and observed phenotypes provide the basis for mapping traits in quantitative genetics. When the phenotype is gene expression, then loci involved in regulatory control can theoretically be implicated ...
Jagalur Manjunatha, Kulp David C
doaj   +1 more source

Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network [PDF]

, 2007
Smooth muscle plays a prominent role in many fundamental processes and diseases, yet our understanding of the transcriptional network regulating its development is very limited.
Astorga (Johansson), Jeanette, Jakobsen, Janus S, Astorga, Jeanette,, Carlsson, Peter,, Furlong, E. E., Furlong, Eileen E M, Carlsson, Peter, Gustafson, E. H., Jakobsen, J. S., Braun, M., Gustafson, E Hilary, Karzynski, M., Karzynski, Michal, Sandmann, T., Sandmann, Thomas, Braun, Martina   +15 more
core   +1 more source

NFIX as a Master Regulator for Lung Cancer Progression

Frontiers in Pharmacology, 2017
About 40% of lung cancer cases globally are diagnosed at the advanced stage. Lung cancer has a high mortality and overall survival in stage I disease is only 70%.
Nor I. A. Rahman, Nor A. Abdul Murad, Mohammad M. Mollah, Rahman Jamal, Rahman Jamal, Roslan Harun, Roslan Harun   +6 more
doaj   +1 more source

YhjC is a novel transcriptional regulator required for Shigella flexneri virulence

Virulence, 2021
Shigella is an intracellular pathogen that primarily infects the human colon and causes shigellosis. Shigella virulence relies largely on the type III secretion system (T3SS) and secreted effectors.
Wanwu Li, Lingyan Jiang, Xiaoqian Liu, Rui Guo, Shuai Ma, Jingting Wang, Shuangshuang Ma, Shujie Li, Huiying Li   +8 more
doaj   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
core   +1 more source

Identification of a prognosis-related phagocytosis regulator gene signature in medulloblastoma

Heliyon
Objectives: The aims of this study were to screen for phagocytosis regulator-related genes in tissue samples from children with medulloblastoma (MB) and to construct a prognostic model based on those genes. Methods: Differentially expressed genes between
Guoqing Han, Xingdong Wang, Ke Pu, Zhenhang Li, Qingguo Li, Xiaoguang Tong   +5 more
doaj   +1 more source

Transcriptome and metabolome profiling to elucidate the mechanism underlying the poor growth of Streptococcus suis serotype 2 after orphan response regulator CovR deletion

Frontiers in Veterinary Science, 2023
The deletion of orphan response regulator CovR reduces the growth rate of Streptococcus suis serotype 2 (S. suis 2). In this study, metabolome and transcriptome profiling were performed to study the mechanisms underlying the poor growth of S.
Bingbing Zong, Yong Xiao, Rui Li, Huanhuan Li, Peiyi Wang, Xiaopei Yang, Yanyan Zhang   +6 more
doaj   +1 more source

The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor molecules

, 2008
Rückert C, Milse J, Albersmeier A, Koch DJ, Pühler A, Kalinowski J. The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor ...
Rückert, Christian ; https://orcid.org/, Daniel J Koch, Johanna Milse, Koch, Daniel J., Albersmeier, Andreas, Christian Rückert, Pühler, Alfred ; https://orcid.org/, Kalinowski, Jörn, Alfred Pühler, Andreas Albersmeier, Milse, Johanna, Jörn Kalinowski   +11 more
core   +1 more source

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]

, 2013
The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Knight, J.R.P., Knight, J. R. P., Knight, John R.P.; id_orcid, Milner, J., Allison, Simon J., Milner, Jo   +5 more
core   +1 more source

Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in Streptomyces malaysiensis F913

Antibiotics, 2022
Nigericin is a polyether antibiotic with potent antibacterial, antifungal, antimalarial and anticancer activity. NigR, the only regulator in the nigericin biosynthetic gene cluster in Streptomyces malaysiensis F913, was identified as a SARP family ...
Junhong Wei, Mengting Ma, Senwen Guo, Yaobo Xu, Jie Xie, Guoqing Pan, Zeyang Zhou   +6 more
doaj   +1 more source