Identification and characterization of a direct activator of a gene transfer agent
Nature Communications, 2019 Gene transfer agents (GTAs) are ‘domesticated’ bacteriophages that can transfer any genes between bacteria. Here, Paul Fogg identifies a protein that directly regulates transcription of GTA genes and whose expression is in turn controlled by a global ...
Paul C. M. Fogg
doaj +1 more source
OsRELA Regulates Leaf Inclination by Repressing the Transcriptional Activity of OsLIC in Rice
Frontiers in Plant Science, 2021 Leaf angle is one of the most important agronomic traits in rice, and changes in leaf angle can alter plant architecture to affect photosynthetic efficiency and thus determine grain yield. Therefore, it is important to identify key genes controlling leaf
Chen-li Zhu +8 more
doaj +1 more source
Agrobacterium tumefaciens estC, Encoding an Enzyme Containing Esterase Activity, Is Regulated by EstR, a Regulator in the MarR Family. [PDF]
PLoS ONE, 2016 Analysis of the A. tumefaciens genome revealed estC, which encodes an esterase located next to its transcriptional regulator estR, a regulator of esterase in the MarR family.
Surawach Rittiroongrad +4 more
doaj +1 more source
Deciphering c-MYC-regulated genes in two distinct tissues [PDF]
, 2011 Background: The transcription factor MYC is a critical regulator of diverse cellular processes, including both replication and apoptosis. Differences in MYC-regulated gene expression responsible for such opposing outcomes in vivo remain obscure.
Lesley Ward +16 more
core +1 more source
Nucleus and gene regulation [PDF]
Current Opinion in Cell Biology, 2006 At the close of a 1973 meeting on Chromosome Structure and Function, an observer commented that chromosomes resembled “a bad day at a macaroni factory” [1]. But things change. Only a few months later nucleosomes were discovered and within just a few more years it began to be appreciated that the nucleus is organized as functionally distinct domains ...
Thoru, Pederson, Robert H, Singer
openaire +2 more sources
BMC Plant Biology, 2019 Background The WOX (WUSCHEL-RELATED HOMEOBOX) gene family encodes a class of transcription factors that are unique to green plants, where they are involved in regulating the development of plant tissues and organs by determining cell fate.
Peng He +6 more
doaj +1 more source
Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals.
PLoS Computational Biology, 2021 Expression QTL (eQTL) analyses have suggested many genes mediating genome-wide association study (GWAS) signals but most GWAS signals still lack compelling explanatory genes.
Jason W Hoskins +7 more
doaj +1 more source
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. [PDF]
, 2014 Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for avoiding autoimmunity. Nevertheless, the extent and nature of this unusual
Nusspaumer, G +18 more
core +1 more source
Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites
mBio, 2020 The heterochromatin environment plays a central role in silencing genes associated with the malaria parasite’s development, survival in the host, and transmission to the mosquito vector.
Yanting Fan +18 more
doaj +1 more source
A novel two-component system involved in the transition to secondary metabolism in Streptomyces coelicolor. [PDF]
PLoS ONE, 2012 BACKGROUND: Bacterial two-component signal transduction regulatory systems are the major set of signalling proteins frequently mediating responses to changes in the environment.
Daniel Rozas +2 more
doaj +1 more source