Genetic Interaction of Aspergillus nidulans galR, xlnR and araR in Regulating D-Galactose and L-Arabinose Release and Catabolism Gene Expression. [PDF]
PLoS ONE, 2015 In Aspergillus nidulans, the xylanolytic regulator XlnR and the arabinanolytic regulator AraR co-regulate pentose catabolism. In nature, the pentose sugars D-xylose and L-arabinose are both main building blocks of the polysaccharide arabinoxylan.
Joanna E Kowalczyk +5 more
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Plasmids manipulate bacterial behaviour through translational regulatory crosstalk.
PLoS Biology, 2023 Beyond their role in horizontal gene transfer, conjugative plasmids commonly encode homologues of bacterial regulators. Known plasmid regulator homologues have highly targeted effects upon the transcription of specific bacterial traits.
Catriona M A Thompson +13 more
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The pneumococcal response to oxidative stress includes a role for Rgg. [PDF]
, 2009 Streptococcus pneumoniae resides in the oxygen-rich environment of the upper respiratory tract, and therefore the ability to survive in the presence of oxygen is an important aspect of its in vivo survival. To investigate how S.
Terra, VS +18 more
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Identification and characterization of a direct activator of a gene transfer agent
Nature Communications, 2019 Gene transfer agents (GTAs) are ‘domesticated’ bacteriophages that can transfer any genes between bacteria. Here, Paul Fogg identifies a protein that directly regulates transcription of GTA genes and whose expression is in turn controlled by a global ...
Paul C. M. Fogg
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I-TRAP: A method to identify transcriptional regulator activated promoters
BMC Infectious Diseases, 2003 Background The differential expression of virulence genes is often used by microbial pathogens in adapting to the environment of their host. The differential expression of such sets of genes can be regulated by RNA polymerase sigma factors.
McLendon Molly M, Shinnick Thomas M
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PAIP1 regulates expression of immune and inflammatory response associated genes at transcript level in liver cancer cell [PDF]
PeerJ, 2023 Poly(A) binding protein interacting protein 1 (PAIP1) is a translation regulator and also regulate the decay of mRNA. PAIP1 has also been reported to be a marker of increased invasive potential of liver cancer. However, the roles and underlying molecular
Jianfeng Zheng +7 more
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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. [PDF]
, 2014 Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for avoiding autoimmunity. Nevertheless, the extent and nature of this unusual
Shikama-Dorn, Noriko +17 more
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Inferred expression regulator activities suggest genes mediating cardiometabolic genetic signals.
PLoS Computational Biology, 2021 Expression QTL (eQTL) analyses have suggested many genes mediating genome-wide association study (GWAS) signals but most GWAS signals still lack compelling explanatory genes.
Jason W Hoskins +7 more
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OsRELA Regulates Leaf Inclination by Repressing the Transcriptional Activity of OsLIC in Rice
Frontiers in Plant Science, 2021 Leaf angle is one of the most important agronomic traits in rice, and changes in leaf angle can alter plant architecture to affect photosynthetic efficiency and thus determine grain yield. Therefore, it is important to identify key genes controlling leaf
Chen-li Zhu +8 more
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Extracting regulator activity profiles by integration of de novo motifs and expression data : characterizing key regulators of nutrient depletion responses in Streptomyces coelicolor [PDF]
, 2012 Determining transcriptional regulator activities is a major focus of systems biology, providing key insight into regulatory mechanisms and co-regulators.
Amin, Rafat +7 more
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