Results 121 to 130 of about 355,590 (262)

A teleost-specific oxygen-immunity axis where FIH activates NF-κB via competitive IκBα binding. [PDF]

Proc Natl Acad Sci U S A
Zhan Z, Liang M, Yu Y, Cui Y, Li Z, Pan W, Zhou Z, Jiang L, Hou Y, He J, Wu K, Weng S, He J, Guo C.   +13 more
europepmc   +1 more source

Reporter Gene [PDF]

, 2020
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Regulatory logic underlying neural crest contributions to the head versus the heart. [PDF]

Proc Natl Acad Sci U S A
Gandhi S, Rajan ARD, Urrutia H, Wilson JS, Ling ITC, Williams R, Sauka-Spengler T, Bronner ME.   +7 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Correction: Heat shock factor-1 alleviates ER-stress in Caenorhabditis elegans. [PDF]

Sci Rep
Ahmed S, Kovács D, Kovács M, Kosztelnik M, Hotzi B, Sigmond T, Saskői É, Vincze VV, Erdélyi V, Deák V, Stiller I, Vellai T, Barna J.   +12 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Stable maintenance of MERVL-positive embryonic stem cells reveals sustained transcriptional programs and enhancer remodeling. [PDF]

J Biol Chem
Geng R, Kidder BL.
europepmc   +1 more source

Reporter Genes

, 2017
Amer M. Najjar, Laura J. Fromme, Shahriar Yaghoubi   +2 more
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source