Results 131 to 140 of about 355,590 (262)

Genome-scale metabolic modeling uncovers cell-type specific signatures associated with APOE variants. [PDF]

iScience
Uzuner Odongo D, Stephenson RA, Cheng L, Yang LG, Narayan PS, Çakır T, Thambisetty M.   +6 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A stable subgenomic reporter coronavirus enables transcriptional profiling of bystander cells. [PDF]

J Gen Virol
Gilbride C, Hemsley-Taylor J, Nunes C, Penn R, Boot J, Pieris N, Tripathy R, Yang Z, Hutchinson M, Platt OK, Ulferts R, Mitter R, Strom M, Santos NB, Bauer DLV, Mears HV.   +15 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic and functional characterization of the natural transformation system in <i>Streptococcus constellatus</i>. [PDF]

Microbiology (Reading)
Sagen AS, Shawrob KSM, Salvadori G, Junges R.   +3 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Spermidine Synthase Gene as a Reporter of Transcription Inhibition in <i>Escherichia coli</i>. [PDF]

Int J Mol Sci
Izzi AR, Chernyshova AP, Zhitlov MY, Rudenko AY, Ozhiganov RM, Ikhalaynen YA, Volynkina IA, Dorofeeva LV, Tashlitsky VN, Rodin IA, Evtushenko LI, Alferova VA, Sergiev PV, Dontsova OA, Lukianov DA.   +14 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mediator subunit MED25 represses ABI5-dependent activation of erucic acid biosynthetic gene <i>FAE1</i> in <i>Brassica napus</i>. [PDF]

Front Plant Sci
Li Z, Zhi S, Tang Y, Li H, Tian M, Pu X, Wu Y.   +6 more
europepmc   +1 more source

Reporter Genes [PDF]

, 2007
openaire   +1 more source