Results 91 to 100 of about 818,447 (288)

Virioplankton assemblages from challenger deep, the deepest place in the oceans

iScience, 2022
Summary: Hadal ocean biosphere, that is, the deepest part of the world’s oceans, harbors a unique microbial community, suggesting a potential uncovered co-occurring virioplankton assemblage.
Chen Gao, Yantao Liang, Yong Jiang, David Paez-Espino, Meiaoxue Han, Chengxiang Gu, Meiwen Wang, Yumei Yang, Fengjiao Liu, Qingwei Yang, Zheng Gong, Xinran Zhang, Zhixiang Luo, Hui He, Cui Guo, Hongbing Shao, Chun Zhou, Yang Shi, Yu Xin, Jinyan Xing, Xuexi Tang, Qilong Qin, Yu-Zhong Zhang, Jianfeng He, Nianzhi Jiao, Andrew McMinn, Jiwei Tian, Curtis A. Suttle, Min Wang   +28 more
doaj  

RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]

, 2016
Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan, Ares, Manuel, Batra, Ranjan, Belzile, Jean-Philippe, Bos, Tomas J, Clark, Elizabeth, Donohue, John Paul, Gelboin-Burkhart, Chelsea, Huang, Hui, Huelga, Stephanie C, Rigo, Frank, Roberts, Brett T, Sathe, Shashank, Spector, Deborah H, Stark, Thomas J, Wheeler, Emily C, Yee, Brian A, Yeo, Gene W   +17 more
core   +2 more sources

Assessing parallel gene histories in viral genomes [PDF]

BMC Evolutionary Biology, 2016
The increasing abundance of sequence data has exacerbated a long known problem: gene trees and species trees for the same terminal taxa are often incongruent. Indeed, genes within a genome have not all followed the same evolutionary path due to events such as incomplete lineage sorting, horizontal gene transfer, gene duplication and deletion, or ...
Beatriz Mengual-Chuliá, Santiago F. Elena, Santiago F. Elena, Santiago F. Elena, Guillaume Lafforgue, Guillaume Lafforgue, Stéphanie Bedhomme, Ignacio G. Bravo   +7 more
openaire   +8 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection [PDF]

, 2017
Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection.
Ali, An, Archambault, Brian P. Daniels, Brien, Cramer, Daniels, Douglas M. Durrant, Furr, Furr, Getts, Harsha Jujjavarapu, Hart, Helen M. Lazear, James P. White, Jessica L. Williams, Michael Gale, Michael S. Diamond, Morga, Pfefferkorn, Richard R. Green, Robyn S. Klein, Rothhammer, Wang   +23 more
core   +3 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

RNA interference identifies domesticated viral genes involved in assembly and trafficking of virus-derived particles in ichneumonid wasps.

PLoS Pathogens, 2019
There are many documented examples of viral genes retained in the genomes of multicellular organisms that may in some cases bring new beneficial functions to the receivers.
Ange Lorenzi, Marc Ravallec, Magali Eychenne, Véronique Jouan, Stéphanie Robin, Isabelle Darboux, Fabrice Legeai, Anne-Sophie Gosselin-Grenet, Mathieu Sicard, Don Stoltz, Anne-Nathalie Volkoff   +10 more
doaj   +1 more source

Anticancer Gene Transfer for Cancer Gene Therapy [PDF]

, 2014
Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells.
A Aiuti, A Aiuti, A Biffi, A Winkeler, AD Bucheit, AW Tong, B Everts, B Kaur, B Moss, B Vogelstein, BR Dix, C Alvarez-Breckenridge, C Heise, C Schliemann, C Springfeld, CC O’Shea, CE Gomez, CE Thomas, CJ Sherr, CM Lai, D Hanahan, D Meirow, D Moroziewicz, D Piwnica-Worms, DF Stojdl, DR Koehler, DR Koehler, E Kelly, EJ Boviatsis, F Simonelli, FJ Morling, GD Trobridge, HA Hoster, HD Klenk, HH Wong, I Friedrich, J Ansari, J Chou, J Cinatl Jr, J Clarke, J Foloppe, J Fueyo, J Hardcastle, J Jin, J Sinkovics, J Veerapong, JA Noser, JC Deutekom van, JM Bergelson, JM Markert, JN Harada, JR Bischoff, JW Bainbridge, K Boztug, K Hamada, K Iguchi, K Nakano, KD Smith, KW Peng, KW Peng, KW Peng, KW Reichard, KX Zhang, L Chen, L Yuan, M Ahonen, M Bergmann, M Chase, M Egeblad, M Kinali, M Sauane, MA Kay, MA Passini, MA Stoff-Khalili, ML Lamfers, MS Ferguson, N Cartier, N Cartier, N Natarajan, N Nayerossadat, NK Green, NL Fox, O Hallgren, O Meier, OG Donnelly, P Msaouel, P Msaouel, PA Lewitt, PG Spear, Q Wu, R Cattaneo, R Cattaneo, R Stripecke, R Waehler, RM Lorence, S Aggarwal, S Chalikonda, S Cirak, S Goverdhana, S Grimm, S Inoue, S Jones, S Kumar, S Nagano, S Suzuki, SA Vorburger, SK Pal, T Flotte, T Gianni, T Kuroda, T Mineta, T Muster, T Sasaki, T Todo, T Todo, T Todo, TC Doyle, TG Huang, WW Spurbeck, X Wang, Y Yi, YY Mahller, Z Peng, Z Zhang, ZS Guo, ZS Guo   +125 more
core   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Genome-wide gene expression analysis of anguillid herpesvirus 1 [PDF]

, 2013
<p>Background: Whereas temporal gene expression in mammalian herpesviruses has been studied extensively, little is known about gene expression in fish herpesviruses.
Davison, A.J., Engelsma, M.Y., Peeters, B.P.H., Rottier, P.J.M., van Beurden, S.J.   +4 more
core   +3 more sources