Results 251 to 260 of about 1,028,351 (305)
Some of the next articles are maybe not open access.
Clinical and Translational Oncology, 2006
Cancer is a multigenic disorder involving mutations of both tumor suppressor genes and oncogenes. A large body of preclinical data, however, has suggested that cancer growth can be arrested or reversed by treatment with gene transfer vectors that carry a single growth inhibitory or pro-apoptotic gene or a gene that can recruit immune responses against ...
P, Mancheño-Corvo, P, Martín-Duque
openaire +2 more sources
Cancer is a multigenic disorder involving mutations of both tumor suppressor genes and oncogenes. A large body of preclinical data, however, has suggested that cancer growth can be arrested or reversed by treatment with gene transfer vectors that carry a single growth inhibitory or pro-apoptotic gene or a gene that can recruit immune responses against ...
P, Mancheño-Corvo, P, Martín-Duque
openaire +2 more sources
Molecular Medicine Today, 1995
Gene therapy is a medical/surgical intervention currently being developed, in which genes are introduced into cells in order to treat or cure a wide variety of human diseases. The field has evolved over the past four decades, with most experimental gene-therapy studies based on the use of viruses to deliver the genes of therapeutic interest.
D A, Treco, R F, Selden
openaire +2 more sources
Gene therapy is a medical/surgical intervention currently being developed, in which genes are introduced into cells in order to treat or cure a wide variety of human diseases. The field has evolved over the past four decades, with most experimental gene-therapy studies based on the use of viruses to deliver the genes of therapeutic interest.
D A, Treco, R F, Selden
openaire +2 more sources
2007
Virus-infection of mammalian cells causes transcriptional induction of many cellular genes, collectively called as "viral stress-inducible genes." The proteins encoded by these genes are essential to maintain cell-virus homeostasis, which is required for both virus replication and host survival.
Ganes C, Sen, Gregory A, Peters
openaire +2 more sources
Virus-infection of mammalian cells causes transcriptional induction of many cellular genes, collectively called as "viral stress-inducible genes." The proteins encoded by these genes are essential to maintain cell-virus homeostasis, which is required for both virus replication and host survival.
Ganes C, Sen, Gregory A, Peters
openaire +2 more sources
Expert Opinion on Investigational Drugs, 1999
Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
openaire +2 more sources
Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
openaire +2 more sources
1983
Endogenous viruses are defined as germline genes that code for the components of a retrovirus. These genes are present in all cells of all tissues of an animal and are inherited by progeny in a Mendelian manner. Two general methods have been used to detect the presence of endogenous viral sequences in DNA of a given species.
U G, Rovigatti, S M, Astrin
openaire +2 more sources
Endogenous viruses are defined as germline genes that code for the components of a retrovirus. These genes are present in all cells of all tissues of an animal and are inherited by progeny in a Mendelian manner. Two general methods have been used to detect the presence of endogenous viral sequences in DNA of a given species.
U G, Rovigatti, S M, Astrin
openaire +2 more sources
2009
The use of molecular techniques in epidemiology gives a better understanding of viral transmission and diversity, and helps to define and characterizc outbreaks. By elucidating transmission patterns and defining outbreak parameters, appropriate preventive measures can be implemented in a timely fashion.
Carol, Holm-Hansen, Kirsti, Vainio
openaire +2 more sources
The use of molecular techniques in epidemiology gives a better understanding of viral transmission and diversity, and helps to define and characterizc outbreaks. By elucidating transmission patterns and defining outbreak parameters, appropriate preventive measures can be implemented in a timely fashion.
Carol, Holm-Hansen, Kirsti, Vainio
openaire +2 more sources
Viral vectors for gene therapy
Trends in Biotechnology, 1998Gene therapy is now being applied to the treatment of wide variety of acquired and inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency of gene transfer. A number of different viral systems are being developed for use as vectors for ex vivo and in vivo gene transfer, including retroviruses, adenoviruses ...
P D, Robbins, H, Tahara, S C, Ghivizzani
openaire +4 more sources
Current Opinion in Biotechnology, 1994
Non-viral gene therapies are currently under development that employ drug-delivery methods for targeting genes to selected cells in the body, where they express therapeutic gene products. Various methods have been described for non-viral gene therapy, ranging from the direct intramuscular injection of purified DNA to the systemic administration of ...
openaire +2 more sources
Non-viral gene therapies are currently under development that employ drug-delivery methods for targeting genes to selected cells in the body, where they express therapeutic gene products. Various methods have been described for non-viral gene therapy, ranging from the direct intramuscular injection of purified DNA to the systemic administration of ...
openaire +2 more sources
2018
Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.
Chi Hong, Sum +3 more
openaire +2 more sources
Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.
Chi Hong, Sum +3 more
openaire +2 more sources