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Current Opinion in Biotechnology, 1994
Non-viral gene therapies are currently under development that employ drug-delivery methods for targeting genes to selected cells in the body, where they express therapeutic gene products. Various methods have been described for non-viral gene therapy, ranging from the direct intramuscular injection of purified DNA to the systemic administration of ...
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Non-viral gene therapies are currently under development that employ drug-delivery methods for targeting genes to selected cells in the body, where they express therapeutic gene products. Various methods have been described for non-viral gene therapy, ranging from the direct intramuscular injection of purified DNA to the systemic administration of ...
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1983
Endogenous viruses are defined as germline genes that code for the components of a retrovirus. These genes are present in all cells of all tissues of an animal and are inherited by progeny in a Mendelian manner. Two general methods have been used to detect the presence of endogenous viral sequences in DNA of a given species.
Susan M. Astrin, Ugo G. Rovigatti
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Endogenous viruses are defined as germline genes that code for the components of a retrovirus. These genes are present in all cells of all tissues of an animal and are inherited by progeny in a Mendelian manner. Two general methods have been used to detect the presence of endogenous viral sequences in DNA of a given species.
Susan M. Astrin, Ugo G. Rovigatti
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Molecular identification of diabetogenic viral gene
Diabetes, 1989The best evidence that viruses have a causative role in the pathogenesis of insulin-dependent diabetes mellitus comes from experiments in mice infected with encephalomyocarditis (EMC) virus. When SJL/J male mice were inoculated with a highly diabetogenic EMC-D virus, diabetes developed in 95% of the animals.
Hyone-Myong Eun +2 more
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2018
Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.
Chi Hong Sum +3 more
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Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of physical and chemical methods capable of gene delivery into the nuclei of target cells.
Chi Hong Sum +3 more
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1997
In 1914, Allard1 noted that challenging certain tobacco species with sap from a mosaic diseased plant resulted in a “destructive rot” at the point of inoculation. This necrotic response in many respects resembled what Stakman,2 in 1915, termed the hypersensitive reaction (HR) in particular oat varieties upon inoculation with Puccinia.
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In 1914, Allard1 noted that challenging certain tobacco species with sap from a mosaic diseased plant resulted in a “destructive rot” at the point of inoculation. This necrotic response in many respects resembled what Stakman,2 in 1915, termed the hypersensitive reaction (HR) in particular oat varieties upon inoculation with Puccinia.
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2004
Somatic gene therapy aims at increasing the expression of deficient or protective factors, or at the suppression of deleterious factors. This goal will probably be achieved best by the use of viral vectors. Currently, vectors are being optimised with respect to transduction properties, levels of transgene expression, and reduction of toxicity and ...
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Somatic gene therapy aims at increasing the expression of deficient or protective factors, or at the suppression of deleterious factors. This goal will probably be achieved best by the use of viral vectors. Currently, vectors are being optimised with respect to transduction properties, levels of transgene expression, and reduction of toxicity and ...
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Non-Viral Gene Delivery Methods
Current Pharmaceutical Biotechnology, 2013Gene delivery has attracted increasing interest as a highly promising therapeutic method to treat various diseases, including both genetic and acquired disorders. Viral-vectors based gene delivery can achieve higher transduction efficiency and long-term gene expression, but they may be associated with some shortcomings, such as immunogenicity ...
Nan Ma +3 more
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Alphaherpes viral genes and their functions
2007Despite biological divergence, human cytomegalovirus (HCMV, HHV-5), on the one hand, and the three human roseolaviruses (HHV-6A, HHV-6B, HHV-7), on the other hand, share approximately 70 evolutionarily conserved and collinear genes (italics, Table 15.1). Mammalian betaherpesviruses probably have a common ancestor dating back over 50 million years.
B. Roizman, CAMPADELLI, MARIA GABRIELLA
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Viral vectors for gene therapy and gene modification approaches
Biochemical Engineering Journal, 2016Abstract Presently, viral vectors are widespread biological products, some of which have already been commercialized. They are derived from viruses modified to render them apt for gene transfer and safe for clinical purposes. They have several applications including the treatment of rare and acquired diseases as well as vaccination.
Merten, O. W., Gaillet, B.
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Manufacturing of Viral Gene Therapies
International Ophthalmology Clinics, 2021G Anthony Ramirez, Mehdi Gasmi
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