Genome-Wide Association Studies on the Autosomes and Chromosome X Uncover Genetic Basis of Reproductive Traits in Yorkshire Pigs [PDF]
AnimalsReproductive efficiency is a fundamental determinant of productivity in pig breeding programs. However, the role of the X chromosome in shaping the genetic basis of reproductive traits remains underexplored.
Teddy Tinashe Chitotombe +3 more
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A survey of human cancer-germline genes: Linking X chromosome localization, DNA methylation and sex-biased expression in early embryos. [PDF]
PLoS GeneticsHuman cancer-germline (CG) genes are a group of testis-specific genes that become aberrantly activated in various tumors. Ongoing studies aim to understand their functions in order to evaluate their potential as anti-cancer therapeutic targets.
Axelle Loriot +3 more
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Incontinentia Pigmenti: A Rare Genodermatosis in a Male Child [PDF]
Journal of Clinical and Diagnostic Research, 2015 Incontinentia pigmenti is rare X-linked dominant disorder. There is no consistent expression of Incontinetia pigmenti in female child, but in male child, they always lead to death in utero.
Dinesh Kumar Narayana Swamy +3 more
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Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly. [PDF]
PLoS ONE, 2015 In most animals that have X and Y sex chromosomes, chromosome-wide mechanisms are used to balance X-linked gene expression in males and females. In the fly Drosophila melanogaster, the dosage compensation mechanism also generally extends to X-linked ...
Rebecca J Linger +2 more
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X-linked genes influence various complex traits in dairy cattle
BMC Genomics, 2023 Background The search for quantitative trait loci (QTL) affecting traits of interest in mammals is frequently limited to autosomes, with the X chromosome excluded because of its hemizygosity in males.
Marie-Pierre Sanchez +8 more
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Brain Sciences, 2021 Nearly 20% of genes located on the X chromosome are associated with neurodevelopmental disorders (NDD) due to their expression and role in brain functioning.
Boudewien A Brand +2 more
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Chromosomal redistribution of male-biased genes in mammalian evolution with two bursts of gene gain on the X chromosome. [PDF]
PLoS Biology, 2010 Mammalian X chromosomes evolved under various mechanisms including sexual antagonism, the faster-X process, and meiotic sex chromosome inactivation (MSCI). These forces may contribute to nonrandom chromosomal distribution of sex-biased genes. In order to
Yong E Zhang +4 more
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No evidence for a global male-specific lethal complex-mediated dosage compensation contribution to the demasculinization of the Drosophila melanogaster X chromosome. [PDF]
PLoS ONE, 2014 In Drosophila melanogaster males, the expression of X-linked genes is regulated by mechanisms that operate on a chromosomal scale. One such mechanism, male-specific lethal complex-dependent X-linked dosage compensation, is thought to broadly enhance the ...
Steven P Vensko, Eric A Stone
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Heliyon, 2023 X chromosome dosage compensation (XDC) refers to the process by which X-linked genes acquire expression equivalence between two sexes. Ohno proposed that XDC is achieved by two-fold upregulations of X-linked genes in both sexes and by silencing one X ...
Zhihao Xing +9 more
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Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes. [PDF]
PLoS Genetics, 2009 In Drosophila, genes expressed in males tend to accumulate on autosomes and are underrepresented on the X chromosome. In particular, genes expressed in testis have been observed to frequently relocate from the X chromosome to the autosomes.
Maria D Vibranovski +3 more
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