Results 11 to 20 of about 5,662,228 (148)

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease

Journal of Neuroinflammation, 2023
Background Microglia, the brain’s principal immune cells, have been implicated in the pathogenesis of Alzheimer’s disease (AD), a condition shown to affect more females than males.
Sarah R. Ocañas, Kevin D. Pham, Jillian E. J. Cox, Alex W. Keck, Sunghwan Ko, Felix A. Ampadu, Hunter L. Porter, Victor A. Ansere, Adam Kulpa, Collyn M. Kellogg, Adeline H. Machalinski, Manu A. Thomas, Zsabre Wright, Ana J. Chucair-Elliott, Willard M. Freeman   +14 more
doaj   +1 more source

Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation

Journal of Immunology Research, 2022
Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy with poor prognosis worldwide. Emerging evidences demonstrated critical roles of lipid de novo synthesis in HCC progression, yet its regulatory mechanisms are not fully ...
Lei Zhu, Kai X. Zhou, Ming Z. Ma, Lin L. Yao, Yan L. Zhang, Hui Li, Chang Du, Xiao M. Yang   +7 more
doaj   +1 more source

Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis

Journal of Immunology Research, 2022
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of ...
Yue Sun, Xiao-Xin Zhang, Shan Huang, Hong Pan, Yan-Zhi Gai, Yao-Qi Zhou, Lei Zhu, Hui-Zhen Nie, Dong-Xue Li   +8 more
doaj   +1 more source

Puncture, MRI and NMR relaxometry data for multiscale analysis of the degradation of apple structure due to thermal treatment

Data in Brief, 2021
The data presented here are related to the research paper entitled “Multiscale NMR analysis of the degradation of apple structure due to thermal treatment” whose aim was to investigate the critical temperature at which the cell membranes of a Golden ...
Alexandre Leca, Sylvie Clerjon, Jean-Marie Bonny, Catherine Renard, Amidou Sissou Traoré   +4 more
doaj   +1 more source

Characterization of integrated prophages within diverse species of clinical nontuberculous mycobacteria

Virology Journal, 2020
Background Nontuberculous mycobacterial (NTM) infections are increasing in prevalence, with current estimates suggesting that over 100,000 people in the United States are affected each year.
Cody Glickman, Sara M. Kammlade, Nabeeh A. Hasan, L. Elaine Epperson, Rebecca M. Davidson, Michael Strong   +5 more
doaj   +1 more source

A jornada da decisão do consumo de música na era digital por parte do consumidor jovem

Diálogo com a Economia Criativa, 2020
Este artigo buscou analisar como se dá a jornada de decisão dos jovens cariocas com alto capital cultural, no que tange ao consumo de música popular. Mais especificamente, buscou-se identificar as etapas e influências que ocorrem na jornada de decisão ...
Cecilia Mattoso, Felipe Genes
doaj   +1 more source

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

Nature Communications, 2020
Chronic lung diseases are characterized by molecular and cellular composition changes. Here the authors use single-cell RNA sequencing to map cell type-specific changes in human tracheal epithelium related to smoking, and to provide evidence for a tuft ...
Katherine C. Goldfarbmuren, Nathan D. Jackson, Satria P. Sajuthi, Nathan Dyjack, Katie S. Li, Cydney L. Rios, Elizabeth G. Plender, Michael T. Montgomery, Jamie L. Everman, Preston E. Bratcher, Eszter K. Vladar, Max A. Seibold   +11 more
doaj   +1 more source

Simulation study and comparative evaluation of viral contiguous sequence identification tools

BMC Bioinformatics, 2021
Background Viruses, including bacteriophages, are important components of environmental and human associated microbial communities. Viruses can act as extracellular reservoirs of bacterial genes, can mediate microbiome dynamics, and can influence the ...
Cody Glickman, Jo Hendrix, Michael Strong   +2 more
doaj   +1 more source

Genetic targeting and anatomical registration of neuronal populations in the zebrafish brain with a new set of BAC transgenic tools

Scientific Reports, 2017
Genetic access to small, reproducible sets of neurons is key to an understanding of the functional wiring of the brain. Here we report the generation of a new Gal4- and Cre-driver resource for zebrafish neurobiology.
Dominique Förster, Irene Arnold-Ammer, Eva Laurell, Alison J. Barker, António M. Fernandes, Karin Finger-Baier, Alessandro Filosa, Thomas O. Helmbrecht, Yvonne Kölsch, Enrico Kühn, Estuardo Robles, Krasimir Slanchev, Tod R. Thiele, Herwig Baier, Fumi Kubo   +14 more
doaj   +1 more source

Generation and Characterization of a Zebrafish Model for ADGRV1-Associated Retinal Dysfunction Using CRISPR/Cas9 Genome Editing Technology

Cells, 2023
Worldwide, around 40,000 people progressively lose their eyesight as a consequence of retinitis pigmentosa (RP) caused by pathogenic variants in the ADGRV1 gene, for which currently no treatment options exist.
Merel Stemerdink, Sanne Broekman, Theo Peters, Hannie Kremer, Erik de Vrieze, Erwin van Wijk   +5 more
doaj   +1 more source