Results 11 to 20 of about 4,146,284 (322)
Predicting synchronized gene coexpression patterns from fibration symmetries in gene regulatory networks in bacteria [PDF]
BMC Bioinformatics 22, 363 (2021), 2021 Background: Gene regulatory networks coordinate the expression of genes across physiological states and ensure a synchronized expression of genes in cellular subsystems, critical for the coherent functioning of cells. Here we address the questions whether it is possible to predict gene synchronization from network structure alone.
arxiv +1 more source
Gene Function Prediction with Gene Interaction Networks: A Context Graph Kernel Approach [PDF]
IEEE Transactions on Information Technology in Biomedicine, 2010, 2022 Predicting gene functions is a challenge for biologists in the post genomic era. Interactions among genes and their products compose networks that can be used to infer gene functions. Most previous studies adopt a linkage assumption, i.e., they assume that gene interactions indicate functional similarities between connected genes.
arxiv +1 more source
Cells, 2023 Worldwide, around 40,000 people progressively lose their eyesight as a consequence of retinitis pigmentosa (RP) caused by pathogenic variants in the ADGRV1 gene, for which currently no treatment options exist.
Merel Stemerdink +5 more
doaj +1 more source
Gene profiling for determining pluripotent genes in a time course microarray experiment [PDF]
Biostatistics, Volume 10, Number 1, 2009, pages 80-93, 2008 In microarray experiments, it is often of interest to identify genes which have a pre-specified gene expression profile with respect to time. Methods available in the literature are, however, typically not stringent enough in identifying such genes, particularly when the profile requires equivalence of gene expression levels at certain time points.
arxiv +1 more source
Nature Communications, 2020 Chronic lung diseases are characterized by molecular and cellular composition changes. Here the authors use single-cell RNA sequencing to map cell type-specific changes in human tracheal epithelium related to smoking, and to provide evidence for a tuft ...
Katherine C. Goldfarbmuren +11 more
doaj +1 more source
Genes, genes everywhere... [PDF]
Nature Reviews Cancer, 2012 Recently published papers using massively parallel sequencing to look at mutations in breast cancer provide food for thought.
openaire +3 more sources
Biomolecules, 2022 Pathogenic missense variants in COCH are associated with DFNA9, an autosomal dominantly inherited type of progressive sensorineural hearing loss with or without vestibular dysfunction.
Sybren M. M. Robijn +9 more
doaj +1 more source
Scientific Reports, 2017 Genetic access to small, reproducible sets of neurons is key to an understanding of the functional wiring of the brain. Here we report the generation of a new Gal4- and Cre-driver resource for zebrafish neurobiology.
Dominique Förster +14 more
doaj +1 more source
Nature Communications, 2022 Lipid metabolism regulates stem cell states and differentiation. Here, the authors demonstrate a requirement in planarians for Apolipoprotein B-mediated neutral lipid transport from intestinal stores to stem cells and their progeny during differentiation
Lily L. Wong +5 more
doaj +1 more source
SLC38A6 expression in macrophages exacerbates pulmonary inflammation
Respiratory Research, 2023 Pulmonary inflammation involves complex changes of the immune cells, in which macrophages play important roles and their function might be influenced by metabolism. Slc38a6 acts as a carrier of nutrient for macrophages (Mφ) to exert the function. In this
Yizhao Peng +10 more
doaj +1 more source