Results 11 to 20 of about 11,860,410 (381)
Theory in Biosciences, 2008 In order to describe a cell at molecular level, a notion of a "gene" is neither necessary nor helpful. It is sufficient to consider the molecules (i.e., chromosomes, transcripts, proteins) and their interactions to describe cellular processes. The downside of the resulting high resolution is that it becomes very tedious to address features on the ...
Prohaska, Sonja, Stadler, Peter F
openaire +3 more sources
Gene Complexity and Gene Duplicability [PDF]
Current Biology, 2005 Eukaryotic genes are on average more complex than prokaryotic genes in terms of expression regulation, protein length, and protein-domain structure [1-5]. Eukaryotes are also known to have a higher rate of gene duplication than prokaryotes do [6, 7]. Because gene duplication is the primary source of new genes [], the average gene complexity in a genome
Xionglei He, Jianzhi Zhang
openaire +3 more sources
Vulnerability genes or plasticity genes? [PDF]
Molecular Psychiatry, 2009 The classic diathesis-stress framework, which views some individuals as particularly vulnerable to adversity, informs virtually all psychiatric research on behavior-gene-environment (G x E) interaction. An alternative framework of 'differential susceptibility' is proposed, one which regards those most susceptible to adversity because of their genetic ...
Belsky, J +5 more
openaire +4 more sources
Simulation study and comparative evaluation of viral contiguous sequence identification tools
BMC Bioinformatics, 2021 Background Viruses, including bacteriophages, are important components of environmental and human associated microbial communities. Viruses can act as extracellular reservoirs of bacterial genes, can mediate microbiome dynamics, and can influence the ...
Cody Glickman +2 more
doaj +1 more source
Strong coupling and long-range collective interactions in optomechanical arrays [PDF]
, 2012 We investigate the collective optomechanics of an ensemble of scatterers inside a Fabry-Perot resonator and identify an optimized configuration where the ensemble is transmissive, in contrast with the usual reflective optomechanics approach.
Dantan, Aurélien +2 more
core +2 more sources
KEGG: Kyoto Encyclopedia of Genes and Genomes
Nucleic Acids Res., 1999 Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules.
Hiroyuki Ogata +5 more
semanticscholar +1 more source
FlyBase: genes and gene models [PDF]
Nucleic Acids Research, 2004 FlyBase (http://flybase.org) is the primary repository of genetic and molecular data of the insect family Drosophilidae. For the most extensively studied species, Drosophila melanogaster, a wide range of data are presented in integrated formats.
Rachel Drysdale, Madeline A. Crosby
openaire +3 more sources
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.
Proceedings of the National Academy of Sciences of the United States of America, 2000 We have developed a simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s).
K. Datsenko, B. Wanner
semanticscholar +1 more source
Nature Communications, 2020 Chronic lung diseases are characterized by molecular and cellular composition changes. Here the authors use single-cell RNA sequencing to map cell type-specific changes in human tracheal epithelium related to smoking, and to provide evidence for a tuft ...
Katherine C. Goldfarbmuren +11 more
doaj +1 more source
Cells, 2023 Worldwide, around 40,000 people progressively lose their eyesight as a consequence of retinitis pigmentosa (RP) caused by pathogenic variants in the ADGRV1 gene, for which currently no treatment options exist.
Merel Stemerdink +5 more
doaj +1 more source