Results 131 to 140 of about 4,042,191 (370)
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Improving Organizations by Replacing the "Mechanical" Model with the "Organic" one [PDF]
Organizations are currently viewed as artificial structures. However, in our opinion, organizations seem to match a biological structure much better. This paper explores this new approach with some interesting conclusions and results: organizations aim ...
George MOLDOVEANU +2 more
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'Workshop for Nagoya Protocol and Plant Treaty National Focal Points in Latin America and the Caribbean’ [PDF]
, 2020 The capacity-building Workshop for National Focal Points in Latin America and the Caribbean on Mutually Supportive Implementation of the Nagoya Protocol and the International Treaty on Plant Genetic Resources for Food and Agriculture, was held 25-28 ...
Argumedo, A. +5 more
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FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo. [PDF]
, 2014 Staphylococcus aureus is a commensal and major pathogen of humans and animals. Comparative genomics of S. aureus populations suggests that colonization of different host species is associated with carriage of mobile genetic elements (MGE), particularly ...
Gould, KA +5 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
New Advances in Diabetes Genetics
International Journal of Molecular Sciences, 2023 Diabetes mellitus constitutes a heterogeneous group of disorders characterized by chronic hyperglycaemia [...]
openaire +2 more sources
The Neolithic transition in Europe: archaeological models and genetic evidence [PDF]
, 2003 The major pattern in the European gene pool is a southeast-northwest frequency gradient of classic genetic markers such as blood groups, which population geneticists initially attributed to the demographic impact of Neolithic farmers dispersing from the ...
Richards, Martin B.
core +4 more sources
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Discover AgricultureA study of genetic variability assists as a fundamental tool for improving barley through the effective utilization of its genetic potential. The present study aimed to assess the extent of genetic variability, heritability, and genetic advance at a 5 ...
Gizaw Wegayehu Tilahun +2 more
doaj +1 more source