Results 81 to 90 of about 232,752 (292)

Estimating Genetic Ancestry Proportions from Faces

PLoS ONE, 2009
Ethnicity can be a means by which people identify themselves and others. This type of identification mediates many kinds of social interactions and may reflect adaptations to a long history of group living in humans. Recent admixture in the US between groups from different continents, and the historically strong emphasis on phenotypic differences ...
Yann C Klimentidis, Mark D Shriver
openaire   +3 more sources

Discovering genetic ancestry using spectral graph theory [PDF]

Genetic Epidemiology, 2009
AbstractAs one approach to uncovering the genetic underpinnings of complex disease, individuals are measured at a large number of genetic variants (usually SNPs) across the genome and these SNP genotypes are assessed for association with disease status.
Ann B, Lee, Diana, Luca, Lambertus, Klei, Bernie, Devlin, Kathryn, Roeder   +4 more
openaire   +2 more sources

Race, ancestry, and genetic risk for kidney failure

Cell Reports Medicine, 2022
In a retrospective analysis of over 62,000 Black and non-Black participants from eight United States cohorts, Gutiérrez et al.1 examined estimated glomerular filtration rate (eGFR) equations to assess racial differences in kidney failure requiring replacement therapy and in mortality across different equations.
Nicholas, Susanne B, Ford, Chandra L, Norris, Keith C   +2 more
openaire   +5 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Genetic ancestry and diagnostic yield of exome sequencing in a diverse population

npj Genomic Medicine
It has been suggested that diagnostic yield (DY) from Exome Sequencing (ES) may be lower among patients with non-European ancestries than those with European ancestry.
Yusuph Mavura, Nuriye Sahin-Hodoglugil, Ugur Hodoglugil, Mark Kvale, Pierre-Marie Martin, Jessica Van Ziffle, W. Patrick Devine, Sara L. Ackerman, Barbara A. Koenig, Pui-Yan Kwok, Mary E. Norton, Anne Slavotinek, Neil Risch   +12 more
doaj   +1 more source

Ancestry-Specific Hypothetical Genetic Feedback About Lung Cancer Risk in African American Individuals Who Smoke: Cognitive, Emotional, and Motivational Effects on Cessation

Behavioral Sciences
Genetic factors play an important role in the risk of developing lung cancer, a disease that disproportionately affects African American (AA) individuals who smoke.
Joel Erblich, Khin Htet, Camille Ragin, Elizabeth Blackman, Isaac Lipkus, Cherie Erkmen, Dina Bitterman   +6 more
doaj   +1 more source

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. [PDF]

, 2017
ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study ...
Barcellos, Lisa F, Cole, Michael, Criswell, Lindsey A, Firestein, Gary S, Graf, John, Halperin, Eran, Harrison, Ruby, Holingue, Calliope, Link, Thomas, Quach, Diana, Quach, Hong L, Rahmani, Elior, Rhead, Brooke, Shah, Khooshbu, Shao, Xiaorong, Sinclair, Elizabeth, Wang, Wei   +16 more
core   +1 more source

The Ancestry of Genetic Segments

ISRN Biomathematics, 2012
Recombination within a DNA segment during the neutral fixation process is studied to determine the number of individuals in previous generations which carry genetic material ancestral to that region in the present generation. If , where is the population size and is the probability of a recombination event within that region per individual in a ...
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dissecting the within-Africa ancestry of populations of African descent in the Americas. [PDF]

PLoS ONE, 2011
The ancestry of African-descended Americans is known to be drawn from three distinct populations: African, European, and Native American. While many studies consider this continental admixture, few account for the genetically distinct sources of ancestry
Klara Stefflova, Matthew C Dulik, Jill S Barnholtz-Sloan, Athma A Pai, Amy H Walker, Timothy R Rebbeck   +5 more
doaj   +1 more source