Results 61 to 70 of about 115,560 (262)

Genetically Estimated Ancestry and the Risk of Pre-Eclampsia

JACC: Advances
Background: Maternal self-reported ethnicity (SRE) is associated with pre-eclampsia (PE) risk and is included in prediction models. Objectives: The objectives of the study were to examine whether genetic ancestry estimates are associated with PE and ...
Frances Conti-Ramsden, PhD, Kypros Nicolaides, PhD, Argyro Syngelaki, PhD, Peter Dixon, PhD, Catherine Williamson, PhD, Maria Tsoukaki, MD, Alan Wright, PhD, Lucy C. Chappell, PhD, Pirro G. Hysi, PhD, Antonio de Marvao, PhD   +9 more
doaj   +1 more source

Ancestry effects on type 2 diabetes genetic risk inference in Hispanic/Latino populations

BMC Medical Genetics, 2020
Background Hispanic/Latino (HL) populations bear a disproportionately high burden of type 2 diabetes (T2D). The ability to predict T2D genetic risk using polygenic risk scores (PRS) offers great promise for improved screening and prevention.
Aroon T. Chande, Lavanya Rishishwar, Andrew B. Conley, Augusto Valderrama-Aguirre, Miguel A. Medina-Rivas, I. King Jordan   +5 more
doaj   +1 more source

Genetic Ancestry and Asthma and Rhinitis Occurrence in Hispanic Children: Findings from the Southern California Children's Health Study. [PDF]

PLoS ONE, 2015
Asthma and rhinitis are common childhood health conditions. Being an understudied and rapidly growing population in the US, Hispanic children have a varying risk for these conditions that may result from sociocultural (including acculturative factors ...
Muhammad T Salam, Tigran Avoundjian, Wendy M Knight, Frank D Gilliland   +3 more
doaj   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

SNVstory: inferring genetic ancestry from genome sequencing data

BMC Bioinformatics
Background Genetic ancestry, inferred from genomic data, is a quantifiable biological parameter. While much of the human genome is identical across populations, it is estimated that as much as 0.4% of the genome can differ due to ancestry. This variation
Audrey E. Bollas, Andrei Rajkovic, Defne Ceyhan, Jeffrey B. Gaither, Elaine R. Mardis, Peter White   +5 more
doaj   +1 more source

Time to Diagnosis Among Children and Adolescents With Cancer in Québec, Canada: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely cancer diagnosis in children and adolescents is important to improving outcomes. We aimed to quantify time to diagnosis and assess variations by patient, demographic and system‐level factors. Procedure We conducted a population‐based study of individuals aged 0–19 years diagnosed with one of 12 cancers from 2010 to 2022 in ...
Callum Mullen, Ronald D. Barr, Erin Strumpf, Mariam El‐Zein, Eduardo L. Franco, Talía Malagón   +5 more
wiley   +1 more source

A Little Bit of That from One of Your Grandparents: Interpreting Others’ Direct-to-Consumer Genetic Ancestry Results

Genealogy, 2020
With more than 25 million tests sold by early 2019, direct-to-consumer genetic ancestry tests expose the public to critical issues of genetics, ancestry, and identity. This study examines how individuals understand the results of a genetic ancestry test.
Piotr S. Bobkowski, John C. Watson, Olushola O. Aromona   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Ancestry-Specific Hypothetical Genetic Feedback About Lung Cancer Risk in African American Individuals Who Smoke: Cognitive, Emotional, and Motivational Effects on Cessation

Behavioral Sciences
Genetic factors play an important role in the risk of developing lung cancer, a disease that disproportionately affects African American (AA) individuals who smoke.
Joel Erblich, Khin Htet, Camille Ragin, Elizabeth Blackman, Isaac Lipkus, Cherie Erkmen, Dina Bitterman   +6 more
doaj   +1 more source

A novel test for gene-ancestry interactions in genome-wide association data.

PLoS ONE, 2012
Genome-wide association study (GWAS) data on a disease are increasingly available from multiple related populations. In this scenario, meta-analyses can improve power to detect homogeneous genetic associations, but if there exist ancestry-specific ...
Joanna L Davies, Jean-Baptiste Cazier, Malcolm G Dunlop, Richard S Houlston, Ian P Tomlinson, Chris C Holmes   +5 more
doaj   +1 more source