Results 61 to 70 of about 232,752 (292)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe [PDF]

, 2019
Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP.
Alexander, Michelle, Benecke, Norbert, Frantz, Laurent A. F., Geörg, Christina, Haile, James, Lin, Audrey T., Linderholm, Anna, Orschiedt, Jörg, Scheu, Amelie, Schier, Wolfram   +9 more
core   +1 more source

Exploring regional aspects of 3D facial variation within European individuals

Scientific Reports, 2023
Facial ancestry can be described as variation that exists in facial features that are shared amongst members of a population due to environmental and genetic effects.
Franziska Wilke, Noah Herrick, Harold Matthews, Hanne Hoskens, Sylvia Singh, John R. Shaffer, Seth M. Weinberg, Mark D. Shriver, Peter Claes, Susan Walsh   +9 more
doaj   +1 more source

The molecular genetics of European ancestry [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999
In an earlier paper we proposed, on the basis of mitochondrial control region variation, that the bulk of modern European mitochondrial DNA (mtDNA) diversity had its roots in the European Upper Palaeolithic. Refining the mtDNA phylogeny and enlarging the sample size both within Europe and the Middle East still support this interpretation and indicate ...
openaire   +2 more sources

Rye: genetic ancestry inference at biobank scale

Nucleic Acids Research, 2022
ABSTRACTBiobank projects around the world are generating genomic data for many thousands and even millions of individuals. Computational methods are needed to handle these massive data sets, including tools for genetic ancestry (GA) inference. Current methods for GA inference are generally accurate, but they are slow and do not scale to biobank-size ...
Andrew B Conley, Lavanya Rishishwar, Maria Ahmad, Shivam Sharma, Emily T Norris, I King Jordan, Leonardo Mariño-Ramírez   +6 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Genetically Estimated Ancestry and the Risk of Pre-Eclampsia

JACC: Advances
Background: Maternal self-reported ethnicity (SRE) is associated with pre-eclampsia (PE) risk and is included in prediction models. Objectives: The objectives of the study were to examine whether genetic ancestry estimates are associated with PE and ...
Frances Conti-Ramsden, PhD, Kypros Nicolaides, PhD, Argyro Syngelaki, PhD, Peter Dixon, PhD, Catherine Williamson, PhD, Maria Tsoukaki, MD, Alan Wright, PhD, Lucy C. Chappell, PhD, Pirro G. Hysi, PhD, Antonio de Marvao, PhD   +9 more
doaj   +1 more source

Ancestry effects on type 2 diabetes genetic risk inference in Hispanic/Latino populations

BMC Medical Genetics, 2020
Background Hispanic/Latino (HL) populations bear a disproportionately high burden of type 2 diabetes (T2D). The ability to predict T2D genetic risk using polygenic risk scores (PRS) offers great promise for improved screening and prevention.
Aroon T. Chande, Lavanya Rishishwar, Andrew B. Conley, Augusto Valderrama-Aguirre, Miguel A. Medina-Rivas, I. King Jordan   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

SNVstory: inferring genetic ancestry from genome sequencing data

BMC Bioinformatics
Background Genetic ancestry, inferred from genomic data, is a quantifiable biological parameter. While much of the human genome is identical across populations, it is estimated that as much as 0.4% of the genome can differ due to ancestry. This variation
Audrey E. Bollas, Andrei Rajkovic, Defne Ceyhan, Jeffrey B. Gaither, Elaine R. Mardis, Peter White   +5 more
doaj   +1 more source