Results 51 to 60 of about 232,752 (292)

Bridging the diversity gap: Analytical and study design considerations for improving the accuracy of trans-ancestry genetic prediction

HGG Advances, 2023
Summary: Genetic prediction of common complex disease risk is an essential component of precision medicine. Currently, genome-wide association studies (GWASs) are mostly composed of European-ancestry samples and resulting polygenic scores (PGSs) have ...
Ozvan Bocher, Arthur Gilly, Young-Chan Park, Eleftheria Zeggini, Andrew P. Morris   +4 more
doaj   +1 more source

The Missing Link of Jewish European Ancestry: Contrasting the Rhineland and the Khazarian Hypotheses [PDF]

, 2012
The question of Jewish ancestry has been the subject of controversy for over two centuries and has yet to be resolved. The "Rhineland Hypothesis" proposes that Eastern European Jews emerged from a small group of German Jews who migrated eastward and ...
Alexander, Atzmon, Balanovsky, Baron, Behar, Behar, Bonné-Tamir, Brook, Browning, Carmeli, Chakravarti, Conrad, Dinur, Dvornik, Eran Elhaik, Excoffier, Finkelstein, Gilbert, Hammer, Hitti, Koestler, Kopelman, Levy-Coffman, Li, McVean, Nebel, Novembre, Ostrer, Ostrer, Pagani, Patai, Patterson, Payaslian, Pickrell, Polak, Price, Price, Purcell, Reich, Sand, Schonberg, Shapira, Shlush, Straten, Straten, Tian, Weiss, Wexler, Zoossmann-Diskin   +48 more
core   +2 more sources

Genetic ancestry and ethnic identity in Ecuador

Human Genetics and Genomics Advances, 2021
We investigated the ancestral origins of four Ecuadorian ethnic groups-Afro-Ecuadorian, Mestizo, Montubio, and the Indigenous Tsáchila-in an effort to gain insight on the relationship between ancestry, culture, and the formation of ethnic identities in Latin America.
Shashwat Deepali Nagar, Andrew B. Conley, Aroon T. Chande, Lavanya Rishishwar, Shivam Sharma, Leonardo Mariño-Ramírez, Gabriela Aguinaga-Romero, Fabricio González‐Andrade, I. King Jordan   +8 more
openaire   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

HGDP and HapMap analysis by Ancestry Mapper reveals local and global population relationships. [PDF]

PLoS ONE, 2012
Knowledge of human origins, migrations, and expansions is greatly enhanced by the availability of large datasets of genetic information from different populations and by the development of bioinformatic tools used to analyze the data. We present Ancestry
Tiago R Magalhães, Jillian P Casey, Judith Conroy, Regina Regan, Darren J Fitzpatrick, Naisha Shah, João Sobral, Sean Ennis   +7 more
doaj   +1 more source

Leveraging genetic ancestry to study health disparities [PDF]

American Journal of Physical Anthropology, 2020
AbstractResearch to understand human genomic variation and its implications in health has great potential to contribute in the reduction of health disparities. Biological anthropology can play important roles in genomics and health disparities research using a biocultural approach. This paper argues that racial/ethnic categories should not be used as a
Ken Batai, Stanley Hooker, Rick A. Kittles   +2 more
openaire   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Relationship between genetic ancestry and metabolic syndrome in community-dwelling old adults

Aspects of Molecular Medicine, 2023
Genetic ancestry may contribute to ethnic differences in the risk of metabolic disorders. Aging leads to a worse ability for homeostasis maintenance, favoring the establishment of metabolic disorders.
Jamille Silva Oliveira, Gabriel Novaes Miranda, Icaro J.S. Ribeiro, Ivna Vidal Freire, Cezar Augusto Casotti, Ana Angélica Leal Barbosa, Rafael Pereira   +6 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Genetic Ancestry and Asthma and Rhinitis Occurrence in Hispanic Children: Findings from the Southern California Children's Health Study. [PDF]

PLoS ONE, 2015
Asthma and rhinitis are common childhood health conditions. Being an understudied and rapidly growing population in the US, Hispanic children have a varying risk for these conditions that may result from sociocultural (including acculturative factors ...
Muhammad T Salam, Tigran Avoundjian, Wendy M Knight, Frank D Gilliland   +3 more
doaj   +1 more source