Results 71 to 80 of about 232,752 (292)

Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure. [PDF]

PLoS ONE, 2013
The objective of this study was to examine the extent to which aldosterone synthase genotype (CYP11B2) and genetic ancestry correlate with atrial fibrillation (AF) and serum aldosterone in African Americans with heart failure.
Adam Bress, Jin Han, Shitalben R Patel, Ankit A Desai, Ibrahim Mansour, Vicki Groo, Kristin Progar, Ebony Shah, Thomas D Stamos, Coady Wing, Joe G N Garcia, Rick Kittles, Larisa H Cavallari   +12 more
doaj   +1 more source

Privacy-Preserving Genetic Relatedness Test [PDF]

, 2016
An increasing number of individuals are turning to Direct-To-Consumer (DTC) genetic testing to learn about their predisposition to diseases, traits, and/or ancestry. DTC companies like 23andme and Ancestry.com have started to offer popular and affordable
De Cristofaro, Emiliano, Liang, Kaitai, Zhang, Yuruo   +2 more
core   +1 more source

Ethnic and geographic differentiation of helicobacter pylori within Iran [PDF]

, 2010
The bacterium Helicobacter pylori colonizes the human stomach, with individual infections persisting for decades. The spread of the bacterium has been shown to reflect both ancient and recent human migrations. We have sequenced housekeeping genes from H.
Latifi-Navid, Saeid, Ghorashi, Seyed Ali, Siavoshi, Farideh, Linz, Bodo, Massarrat, Sadegh, Khegay, Tanya, Salmanian, Ali-Hatef, Shayesteh, Ali Akbar, Masoodi, Mohsen, Ghanadi, Koroush, Ganji, Azita, Suerbaum, Sebastian, Achtman, Mark, Malekzadeh, Reza, Falush, Daniel   +14 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Little Bit of That from One of Your Grandparents: Interpreting Others’ Direct-to-Consumer Genetic Ancestry Results

Genealogy, 2020
With more than 25 million tests sold by early 2019, direct-to-consumer genetic ancestry tests expose the public to critical issues of genetics, ancestry, and identity. This study examines how individuals understand the results of a genetic ancestry test.
Piotr S. Bobkowski, John C. Watson, Olushola O. Aromona   +2 more
doaj   +1 more source

Reconstructing Genetic Ancestry Blocks in Admixed Individuals [PDF]

The American Journal of Human Genetics, 2006
A chromosome in an individual of recently admixed ancestry resembles a mosaic of chromosomal segments, or ancestry blocks, each derived from a particular ancestral population. We consider the problem of inferring ancestry along the chromosomes in an admixed individual and thereby delineating the ancestry blocks.
Tang, Hua, Coram, Marc, Wang, Pei, Zhu, Xiaofeng, Risch, Neil   +4 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A novel test for gene-ancestry interactions in genome-wide association data.

PLoS ONE, 2012
Genome-wide association study (GWAS) data on a disease are increasingly available from multiple related populations. In this scenario, meta-analyses can improve power to detect homogeneous genetic associations, but if there exist ancestry-specific ...
Joanna L Davies, Jean-Baptiste Cazier, Malcolm G Dunlop, Richard S Houlston, Ian P Tomlinson, Chris C Holmes   +5 more
doaj   +1 more source

GemTools: A fast and efficient approach to estimating genetic ancestry [PDF]

, 2011
To uncover the genetic basis of complex disease, individuals are often measured at a large number of genetic variants (usually SNPs) across the genome. GemTools provides computationally efficient tools for modeling genetic ancestry based on SNP genotypes.
Devlin, Bernie, Kent, Brian P., Klei, Lambertus, Melhem, Nadine, Roeder, Kathryn   +4 more
core  

Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium. [PDF]

, 2019
ObjectivePopulations of Mexican American ancestry are at an increased risk for nonalcoholic fatty liver disease. The objective of this study was to determine whether loci in known and novel genes were associated with variation in aspartate ...
Chen, Yii-Der I, Fingerlin, Tasha E, Goodarzi, Mark O, Guo, Xiuqing, Langefeld, Carl D, Norris, Jill M, Palmer, Nicholette D, Raffel, Leslie J, Rotter, Jerome I, Taylor, Kent D, Wagenknecht, Lynne E, Wang, Nan, Watanabe, Richard M, Williams, Adrienne H, Xiang, Anny H, Young, Kendra A   +15 more
core   +2 more sources