Results 71 to 80 of about 115,560 (262)

Genetic ancestry of families of putative Inka descent [PDF]

Molecular Genetics and Genomics, 2018
This study focuses on the descendants of the royal Inka family. The Inkas ruled Tawantinsuyu, the largest pre-Columbian empire in South America, which extended from southern Colombia to central Chile. The origin of the royal Inkas is currently unknown.
Sandoval, José R., Lacerda, Daniela R., Jota, Marilza S., Elward, Ronald, Acosta, Oscar, Pinedo, Donaldo, Danos, Pierina, Cuellar, Cinthia, Revollo, Susana, Santos, Fabricio R., Fujita, Ricardo   +10 more
openaire   +5 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Genetic ancestry and diagnostic yield of exome sequencing in a diverse population

npj Genomic Medicine
It has been suggested that diagnostic yield (DY) from Exome Sequencing (ES) may be lower among patients with non-European ancestries than those with European ancestry.
Yusuph Mavura, Nuriye Sahin-Hodoglugil, Ugur Hodoglugil, Mark Kvale, Pierre-Marie Martin, Jessica Van Ziffle, W. Patrick Devine, Sara L. Ackerman, Barbara A. Koenig, Pui-Yan Kwok, Mary E. Norton, Anne Slavotinek, Neil Risch   +12 more
doaj   +1 more source

African genetic ancestry is associated with lower frequency of PNPLA3 G allele in non-alcoholic fatty liver in an admixed population

Annals of Hepatology, 2022
Introduction and objectives: PNPLA3 (rs738409) and TM6SF2 (rs58542926) variants, interindividual and ethnic differences may be risk factors for non-alcoholic fatty liver disease (NAFLD).
Lourianne Nascimento Cavalcante, Jun Porto, Daniel Mazo, Adhemar Longatto-Filho, José Tadeu Stefano, Andre Castro Lyra, Flair Jose Carrilho, Rui Manuel Reis, Venâncio A.F. Alves, Arun J. Sanyal, Claudia P Oliveira   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genetic ancestry, admixture and health determinants in Latin America

BMC Genomics, 2018
Background Modern Latin American populations were formed via genetic admixture among ancestral source populations from Africa, the Americas and Europe.
Emily T. Norris, Lu Wang, Andrew B. Conley, Lavanya Rishishwar, Leonardo Mariño-Ramírez, Augusto Valderrama-Aguirre, I. King Jordan   +6 more
doaj   +1 more source

Dissecting the within-Africa ancestry of populations of African descent in the Americas. [PDF]

PLoS ONE, 2011
The ancestry of African-descended Americans is known to be drawn from three distinct populations: African, European, and Native American. While many studies consider this continental admixture, few account for the genetically distinct sources of ancestry
Klara Stefflova, Matthew C Dulik, Jill S Barnholtz-Sloan, Athma A Pai, Amy H Walker, Timothy R Rebbeck   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Ancestry-related distribution of Runs of homozygosity and functional variants in Qatari population

BMC Genomic Data, 2022
Background Describing how genetic history shapes the pattern of medically relevant variants could improve the understanding of how specific loci interact with each other and affect diseases and traits prevalence. The Qatari population is characterized by
Massimo Mezzavilla, Massimiliano Cocca, Pierpaolo Maisano Delser, Ramin Badii, Fatemeh Abbaszadeh, Khalid Abdul Hadi, Girotto Giorgia, Paolo Gasparini   +7 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source