Results 41 to 50 of about 115,560 (262)

Genetic ancestry and radical prostatectomy findings in Hispanic/Latino patients

Frontiers in Oncology
BackgroundAfrican ancestry is a known factor associated with the presentation and aggressiveness of prostate cancer (PC). Hispanic/Latino populations exhibit varying degrees of genetic admixture across Latin American countries, leading to diverse levels ...
Natalia L. Acosta-Vega, Natalia L. Acosta-Vega, Rodolfo Varela, Rodolfo Varela, Jorge Andrés Mesa, Jone Garai, Alberto Gómez-Gutiérrez, Silvia J. Serrano-Gómez, Jovanny Zabaleta, Jovanny Zabaleta, María Carolina Sanabria-Salas, Alba L. Combita, Alba L. Combita   +12 more
doaj   +1 more source

Informativeness of Genetic Markers for Inference of Ancestry* [PDF]

The American Journal of Human Genetics, 2003
Inference of individual ancestry is useful in various applications, such as admixture mapping and structured-association mapping. Using information-theoretic principles, we introduce a general measure, the informativeness for assignment (I(n)), applicable to any number of potential source populations, for determining the amount of information that ...
Rosenberg, Noah A., Li, Lei M., Ward, Ryk, Pritchard, Jonathan K.   +3 more
openaire   +2 more sources

The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico. [PDF]

PLoS ONE, 2014
Diverse socioeconomic and clinical factors influence susceptibility to tuberculosis (TB) disease in Mexico. The role of genetic factors, particularly those that differ between the parental groups that admixed in Mexico, is unclear. The objectives of this
Bonnie N Young, Adrian Rendón, Adrian Rosas-Taraco, Jack Baker, Meghan Healy, Jessica M Gross, Jeffrey Long, Marcos Burgos, Keith L Hunley   +8 more
doaj   +1 more source

Population Genetics Models of Local Ancestry [PDF]

Genetics, 2012
AbstractMigrations have played an important role in shaping the genetic diversity of human populations. Understanding genomic data thus requires careful modeling of historical gene flow. Here we consider the effect of relatively recent population structure and gene flow and interpret genomes of individuals that have ancestry from multiple source ...
openaire   +3 more sources

Race, ancestry, and genetic risk for kidney failure

Cell Reports Medicine, 2022
In a retrospective analysis of over 62,000 Black and non-Black participants from eight United States cohorts, Gutiérrez et al.1 examined estimated glomerular filtration rate (eGFR) equations to assess racial differences in kidney failure requiring replacement therapy and in mortality across different equations.
Nicholas, Susanne B, Ford, Chandra L, Norris, Keith C   +2 more
openaire   +5 more sources

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos

Human Genomics, 2019
Background Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise.
Julyann Pérez-Mayoral, Marievelisse Soto-Salgado, Ebony Shah, Rick Kittles, Mariana C. Stern, Myrta I. Olivera, María Gonzalez-Pons, Segundo Rodriguez-Quilichinni, Marla Torres, Jose S. Reyes, Luis Tous, Nicolas López, Victor Carlo Chevere, Marcia Cruz-Correa   +13 more
doaj   +1 more source

HGDP and HapMap analysis by Ancestry Mapper reveals local and global population relationships. [PDF]

PLoS ONE, 2012
Knowledge of human origins, migrations, and expansions is greatly enhanced by the availability of large datasets of genetic information from different populations and by the development of bioinformatic tools used to analyze the data. We present Ancestry
Tiago R Magalhães, Jillian P Casey, Judith Conroy, Regina Regan, Darren J Fitzpatrick, Naisha Shah, João Sobral, Sean Ennis   +7 more
doaj   +1 more source

Bridging the diversity gap: Analytical and study design considerations for improving the accuracy of trans-ancestry genetic prediction

HGG Advances, 2023
Summary: Genetic prediction of common complex disease risk is an essential component of precision medicine. Currently, genome-wide association studies (GWASs) are mostly composed of European-ancestry samples and resulting polygenic scores (PGSs) have ...
Ozvan Bocher, Arthur Gilly, Young-Chan Park, Eleftheria Zeggini, Andrew P. Morris   +4 more
doaj   +1 more source

Ancestry Testing and the Practice of Genetic Counseling [PDF]

Journal of Genetic Counseling, 2016
AbstractAncestry testing is a home DNA test with many dimensions; in some cases, the implications and outcomes of testing cross over into the health sphere. Common reasons for seeking ancestry testing include determining an estimate of customer's ethnic background, identifying genetic relatives, and securing a raw DNA data file that can be used for ...
Brianne E, Kirkpatrick, Misha D, Rashkin
openaire   +2 more sources