Results 1 to 10 of about 1,408,290 (268)

Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations

Frontiers in Genetics, 2019
Background: Esophageal squamous cell carcinoma (ESCC), one of the most aggressive cancers, is endemic in Sub-Saharan Africa, constituting a major health burden.
Hannah Simba, Helena Kuivaniemi, Vittoria Lutje, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Vikash Sewram   +8 more
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Variable Effects of PD-Risk Associated SNPs and Variants in Parkinsonism-Associated Genes on Disease Phenotype in a Community-Based Cohort

Frontiers in Neurology, 2021
Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely
Katerina Markopoulou, Bruce A. Chase, Ashvini P. Premkumar, Bernadette Schoneburg, Ninith Kartha, Jun Wei, Hongjie Yu, Alexander Epshteyn, Lisette Garduno, Anna Pham, Rosa Vazquez, Roberta Frigerio, Demetrius Maraganore   +12 more
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Analysis of the association between rs12917707 and rs11864909 single nucleotide polymorphisms in the region of the uromoduline gene and chronic kidney disease – a family-based study

Annals of Agricultural and Environmental Medicine, 2017
Chronic kidney disease (CKD) is an important challange for healthcare systems wordwide because of its high prevalence and serious late complications.
Joanna Żywiec, Katarzyna Kiliś-Pstrusińska, Maciej Tomaszewski, Władysław Grzeszczak   +3 more
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ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population

Frontiers in Neuroscience, 2021
Background: Studies in animal models have suggested that aldehyde dehydrogenase 1 (encoded by ALDH1A1) protects against Parkinson’s disease (PD) by reducing toxic metabolites of dopamine.
Hui-Hui Fan, Hui-Hui Fan, Qing Guo, Jing Zheng, Yi-Zhi Lian, Shi-Shi Huang, Yue Sun, Ming Zou, Jian-Hong Zhu, Jian-Hong Zhu, Xiong Zhang, Xiong Zhang   +11 more
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Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations

Genetics and Molecular Biology, 2017
Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors.
Lixia Yu, Xiaoai Zhang, Yun Zhai, Hongxing Zhang, Wei Yue, Xiumei Zhang, Zhifu Wang, Hong Zhou, Gangqiao Zhou, Feng Gong   +9 more
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Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

Frontiers in Psychiatry, 2019
Aims: Serotonin 1A receptor (5-HT1A) and vascular endothelial growth factor (VEGF) are widely expressed in the neurons of the hippocampus and have significant roles in the pathophysiological processes of major depressive disorders (MDDs).
Dong Han, Zhengxue Qiao, Dong Qi, Jiarun Yang, Xiuxian Yang, Jingsong Ma, Lin Wang, Xuejia Song, Erying Zhao, Jian Zhang, Yanjie Yang, Xiaohui Qiu   +11 more
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Systematic Review of Genomic Associations with Blood Pressure and Hypertension in Populations with African-Ancestry

Frontiers in Genetics, 2021
Background: Despite hypertension being highly prevalent in individuals with African-ancestry, they are under-represented in large genome-wide association studies.
S. Singh, S. Singh, J-T. Brandenburg, A. Choudhury, F.X. Gómez-Olivé, M. Ramsay, M. Ramsay   +6 more
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Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk

Radiology and Oncology, 2016
Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in ...
Hudler Petra, Britovsek Nina Kocevar, Grazio Snjezana Frkovic, Komel Radovan   +3 more
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Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children

Human Genomics, 2011
Type 2 diabetes represents an increasing health burden. Its prevalence is rising among younger age groups and differs among racial/ethnic groups. Little is known about its genetic basis, including whether there is a genetic basis for racial/ethnic ...
Klimentidis Yann C, Divers Jasmin, Casazza Krista, Beasley T, Allison David B, Fernandez Jose R   +5 more
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Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia

Biomolecules & Biomedicine, 2012
Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder.
Lilijana Oruč, Lejla Kapur-Pojskić, Jasmin Ramić, Naris Pojskić, Kasim Bajrović   +4 more
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