Results 1 to 10 of about 7,409,346 (224)

GemTools: A fast and efficient approach to estimating genetic ancestry [PDF]

arXiv, 2011
To uncover the genetic basis of complex disease, individuals are often measured at a large number of genetic variants (usually SNPs) across the genome. GemTools provides computationally efficient tools for modeling genetic ancestry based on SNP genotypes.
Devlin, Bernie, Kent, Brian P., Klei, Lambertus, Melhem, Nadine, Roeder, Kathryn   +4 more
arxiv   +3 more sources

Monitoring of environmental gases and calf health in Italian Mediterranean buffalo herd

Revista Científica, 2023
In buffalo breeding, calves require special attention and housing systems that provide thermal comfort, good air quality, brightness, and adequate space.
Simona Leonetti , Monica Ambrosio , Mirko Scamardella , Chiara Caso , Angelo Coletta   +4 more
doaj   +1 more source

Expert Consensus on Clinical Specimen Preservation and Biosafety Protection in the Context of Managing COVID-19 with Measures against Class B Infectious Diseases

Xiehe Yixue Zazhi, 2023
During the past three years, the national prevention and control policies for coronavirus disease 2019(COVID-19) have gone from'Class A control' to 'Class B control'.
Clinical Data and Biobank Committee of China Research Hospital Association, Guangdong Human Genetic Resource Biobanking and Applications Association   +1 more
doaj   +1 more source

LocusZoom.js: interactive and embeddable visualization of genetic association study results

bioRxiv, 2021
LocusZoom.js is a JavaScript library for creating interactive web-based visualizations of genetic association study results. It can display one or more traits in the context of relevant biological data (such as gene models and other genomic annotation ...
Andrew P. Boughton, R. Welch, M. Flickinger, Peter Vandehaar, D. Taliun, G. Abecasis, M. Boehnke   +6 more
semanticscholar   +1 more source

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics [PDF]

PLoS Genetics, 2013
Genetic association studies, in particular the genome-wide association study (GWAS) design, have provided a wealth of novel insights into the aetiology of a wide range of human diseases and traits, in particular cardiovascular diseases and lipid ...
C. Giambartolomei, Damjan Vukcevic, E. Schadt, L. Franke, A. Hingorani, C. Wallace, V. Plagnol   +6 more
semanticscholar   +1 more source

Fine-mapping genetic associations [PDF]

Human Molecular Genetics, 2020
AbstractWhilst thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further ‘fine-mapping’ step. We review the basic fine-mapping approach, which is computationally fast and requires only summary data, but depends on an assumption of a single causal variant per ...
Hutchinson, Anna, Asimit, Jennifer, Wallace, Chris   +2 more
openaire   +3 more sources

Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses

Scientific Reports, 2021
The Thoroughbred breed was formed by crossing Oriental horse breeds and British native horses and is currently used in horseracing worldwide. In this study, we constructed a single-nucleotide variant (SNV) database using data from 101 Thoroughbred ...
Teruaki Tozaki, Aoi Ohnuma, Mio Kikuchi, Taichiro Ishige, Hironaga Kakoi, Kei-ichi Hirota, Kanichi Kusano, Shun-ichi Nagata   +7 more
doaj   +1 more source

Variable Effects of PD-Risk Associated SNPs and Variants in Parkinsonism-Associated Genes on Disease Phenotype in a Community-Based Cohort

Frontiers in Neurology, 2021
Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely
Katerina Markopoulou, Bruce A. Chase, Ashvini P. Premkumar, Bernadette Schoneburg, Ninith Kartha, Jun Wei, Hongjie Yu, Alexander Epshteyn, Lisette Garduno, Anna Pham, Rosa Vazquez, Roberta Frigerio, Demetrius Maraganore   +12 more
doaj   +1 more source

Systematic Review of Genomic Associations with Blood Pressure and Hypertension in Populations with African-Ancestry

Frontiers in Genetics, 2021
Background: Despite hypertension being highly prevalent in individuals with African-ancestry, they are under-represented in large genome-wide association studies.
S. Singh, S. Singh, J-T. Brandenburg, A. Choudhury, F.X. Gómez-Olivé, M. Ramsay, M. Ramsay   +6 more
doaj   +1 more source

Power and Sample Size Calculations for Genetic Association Studies in the Presence of Genetic Model Misspecification

Human Heredity, 2020
Introduction: When analyzing data from large-scale genetic association studies, such as targeted or genome-wide resequencing studies, it is common to assume a single genetic model, such as dominant or additive, for all tests of association between a ...
Camille M. Moore, Sean Jacobson, T. Fingerlin   +2 more
semanticscholar   +1 more source