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Xiehe Yixue Zazhi, 2023 During the past three years, the national prevention and control policies for coronavirus disease 2019(COVID-19) have gone from'Class A control' to 'Class B control'.
Clinical Data and Biobank Committee of China Research Hospital Association +1 more
doaj +1 more source
Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses
Scientific Reports, 2021 The Thoroughbred breed was formed by crossing Oriental horse breeds and British native horses and is currently used in horseracing worldwide. In this study, we constructed a single-nucleotide variant (SNV) database using data from 101 Thoroughbred ...
Teruaki Tozaki +7 more
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Frontiers in Neurology, 2021 Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely
Katerina Markopoulou +12 more
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Editorial: Genetic association studies in oil seeds [PDF]
Frontiers in GeneticsV. G. Shobhana +3 more
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Frontiers in Genetics, 2021 Background: Despite hypertension being highly prevalent in individuals with African-ancestry, they are under-represented in large genome-wide association studies.
S. Singh +6 more
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Fine-mapping genetic associations [PDF]
Human Molecular Genetics, 2020 AbstractWhilst thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further ‘fine-mapping’ step. We review the basic fine-mapping approach, which is computationally fast and requires only summary data, but depends on an assumption of a single causal variant per ...
Hutchinson, Anna +2 more
openaire +3 more sources
The anatomical distribution of genetic associations [PDF]
Nucleic Acids Research, 2015 AbstractDeeper understanding of the anatomical intermediaries for disease and other complex genetic traits is essential to understanding mechanisms and developing new interventions. Existing ontology tools provide functional annotations for many genes in the genome and they are widely used to develop mechanistic hypotheses based on genetic and ...
Wells, Alan +8 more
openaire +5 more sources
Genetic Alterations Associated With Cryptorchidism [PDF]
JAMA, 2008 Cryptorchidism is the most frequent congenital birth defect in male children and represents an important risk factor for infertility and testicular cancer. Major regulators of testicular descent are the hormones insulin-like factor 3 (INSL3) and testosterone, and disruption of these pathways might cause cryptorchidism.To determine the frequency of ...
FERLIN, ALBERTO +5 more
openaire +6 more sources
Genetic variants associated with sepsis
PLOS ONE, 2022 Background The variable presentations and different phenotypes of sepsis suggest that risk of sepsis comes from many genes each having a small effect. The cumulative effect can be used to create individual risk profile. The purpose of this study was to create a polygenic risk score and determine the genetic variants associated with sepsis.
Milo Engoren +5 more
openaire +4 more sources