Results 91 to 100 of about 8,825,337 (378)

A perspective on interaction effects in genetic association studies

Genetic Epidemiology, 2016
The identification of gene–gene and gene–environment interaction in human traits and diseases is an active area of research that generates high expectation, and most often lead to high disappointment. This is partly explained by a misunderstanding of the
H. Aschard
semanticscholar   +1 more source

Diurnal preference and sleep quality: same genes? A study of young adult twins [PDF]

, 2010
The aims of this study were to examine the genetic and environmental influences on diurnal preference and sleep quality, the association between these phenotypes, the genetic and environmental influences on this association, and the magnitude of overlap ...
Nicola L. Barclay, Thalia C. Eley, Daniel J. Buysse, Simon N. Archer, Alice M. Gregory, American Academy of Sleep Medicine, Archer SN, Archer SN, Borbely AA, Borbely AA, Brummett BH, Buysse DJ, Carrier J, Cohen DJ, Daan S, Dijk D, Drennan SJ, Edinger JD, Gregory AM, Gregory AM, Gregory AM, Heath AC, Horne JA, Katzenberg D, Lee HJ, McGue M, Meltzer H, Neale MC, Neale MC, Neale MC, Ohayon M, Ohayon M, Ong JC, Paunio T, Sham P, Shiihara Y, Smith CS, Talliard J, Virtanen P, Waterhouse J   +39 more
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Genome-Wide Association and Linkage Analysis of Quantitative Traits: Comparison pf Likelihood-Ratio Test and Conditional Score Statistic [PDF]

, 2009
Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype.
Dupuis, Josée, Hendricks, Audrey E, Zhu, Yanyan   +2 more
core   +1 more source

Pooled Association Tests for Rare Genetic Variants: A Review and Some New Results

, 2014
In the search for genetic factors that are associated with complex heritable human traits, considerable attention is now being focused on rare variants that individually have small effects.
Derkach, Andriy, Lawless, Jerry F., Sun, Lei   +2 more
core   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Nature Genetics, 2018
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6–11.
Mengzhen Liu, Yu Jiang, R. Wedow, Yue Li, D. Brazel, Fang Chen, G. Datta, J. Dávila-Velderrain, Daniel McGuire, C. Tian, Xiaowei Zhan, M. B. A. R. K. K. S. L. P. N. Agee Alipanahi Auton Bell Bryc Elson Fontanillas F, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, D. Hinds, Bethann S. Hromatka, K. Huber, A. Kleinman, N. Litterman, M. Mcintyre, J. Mountain, C. Northover, J. Sathirapongsasuti, O. Sazonova, J. Shelton, S. Shringarpure, J. Tung, V. Vacic, C. H. Wilson, S. Pitts, Amy Anne Heidi Bendik S. Børge Eystein Gunnar Håvard I Mitchell Skogholt Winsvold Sivertsen Stordal Morke, Amy Mitchell, A. Skogholt, B. Winsvold, Borge Sivertsen, E. Stordal, G. Morken, H. Kallestad, I. Heuch, J. Zwart, K. Fjukstad, L. Pedersen, M. Gabrielsen, M. B. Johnsen, M. Skrove, M. Indredavik, O. K. Drange, O. Bjerkeset, S. Børte, S. Stensland, H. Choquet, A. Docherty, J. Faul, Johanna R. Foerster, L. Fritsche, S. Gordon, J. Haessler, J. Hottenga, Hongyan Huang, Seonkyeong Jang, P. Jansen, Yueh Ling, R. Mägi, N. Matoba, George Mcmahon, A. Mulas, V. Orrù, T. Palviainen, Anita Pandit, Gunnar W. Reginsson, Jennifer A. Smith, Amy E Taylor, Constance Turman, G. Willemsen, Hannah Young, K. Young, G. Zajac, Wei Zhao, Wei Zhou, G. Bjornsdottir, J. Boardman, M. Boehnke, D. Boomsma, Chu Chen, F. Cucca, G. Davies, C. Eaton, M. Ehringer, T. Esko, E. Fiorillo, N. Gillespie, D. Gudbjartsson, T. Haller, K. Harris, A. Heath, J. Hewitt, I. Hickie, J. Hokanson, Christian J. Hopfer, D. Hunter, W. Iacono, Eric O. Johnson, Y. Kamatani, S. Kardia, M. Keller, Manolis Kellis, C. Kooperberg, P. Kraft, K. Krauter, M. Laakso, P. Lind, A. Loukola, S. Lutz, P. Madden, N. Martin, M. McGue, M. McQueen, S. Medland, A. Metspalu, K. Mohlke, J. Nielsen, Y. Okada, U. Peters, T. Polderman, D. Posthuma, A. Reiner, J. Rice, E. Rimm, R. rose, V. Runarsdottir, M. Stallings, A. Stančáková, H. Stefánsson, K. Thai, H. Tindle, Thorarinn Tyrfingsson, T. Wall, D. Weir, Constance Weisner, J. Whitfield, B. Winsvold, J. Yin, L. Zuccolo, L. Bierut, K. Hveem, James J. Lee, M. Munafo, N. Saccone, C. Willer, M. Cornelis, S. David, D. Hinds, E. Jorgenson, J. Kaprio, J. Stitzel, K. Stefánsson, T. Thorgeirsson, G. Abecasis, Dajiang J. Liu, S. Vrieze   +165 more
semanticscholar   +1 more source

Contribution of Rare and Common APOE Variants to Familial Hypercholesterolemia in Spanish Cohort

Cardiogenetics
Our aim was to determine whether rare APOE pathogenic variants (PV) and the common e2/e3/e4 polymorphism were associated with the risk of familial hypercholesterolemia (FH).
Lorena M. Vega-Prado, Daniel Vázquez-Coto, Francisco Villazón, Lorena Suárez-Gutiérrez, Ceferino Martínez-Faedo, Edelmiro Menéndez-Torre, María Riestra, Silvia González-Martínez, Gala Gutiérrez-Buey, Claudia García-Lago, Juan Gómez, Victoria Alvarez, Helena Gil, Rebeca Lorca, Eliecer Coto   +14 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia

Behavioral and Brain Functions, 2012
Background The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors ...
Uezato Akihito, Kimura-Sato Junko, Yamamoto Naoki, Iijima Yoshimi, Kunugi Hiroshi, Nishikawa Toru   +5 more
doaj   +1 more source