Results 91 to 100 of about 8,691,632 (395)

Meta-Analysis of Genetic Association Studies

Annals of Laboratory Medicine, 2015
The object of this review is to help readers to understand meta-analysis of genetic association study. Genetic association studies are a powerful approach to identify susceptibility genes for common diseases. However, the results of these studies are not
Y. Lee
semanticscholar   +1 more source

A genome-wide scan for common alleles affecting risk for autism [PDF]

, 2010
Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs).
A. Battaglia, A. C. Lionel, A. Crossett, A. D. Paterson, A. Estes, A. J. Bailey, A. Kolevzon, A. Le Couteur, A. M. Vicente, A. Merikangas, A. Noor, A. P. Monaco, A. P. Thompson, A. Pickles, A. Poustka, A. Prasad, A. R. Carson, A. T. Pagnamenta, A. Tryfon, Abrahams, Arai, B. A. Fernandez, B. Devlin, B. L. Leventhal, B. L. Yaspan, B. Parrini, B. Roge, B. S. Abrahams, B. Thiruvahindrapduram, Bailey, Baron-Cohen, Browning, Butler, Buxbaum, C. Betancur, C. Correia, C. Corsello, C. Gillberg, C. J. McDougle, C. Kim, C. Lord, C. M. Freitag, C. M. Lajonchere, C. Mantoulan, C. Noakes, C. R. Marshall, C. Strawbridge, Constantino, Cook, Cordell, D. H. Geschwind, D. J. Posey, D. Pinto, D. Sato, D. Zurawiecki, Dhami, Duan, E. A. Heron, E. Bacchelli, E. Duketis, E. Fombonne, E. H. Cook, E. L. Crawford, E. M. Wijsman, E. Maestrini, F. Duque, F. Poustka, F. Volkmar, Fernell, Fombonne, G. Baird, G. Casallo, G. D. Schellenberg, G. Dawson, G. Hughes, G. K. Mirza, G. Nygren, G. Oliveira, Geschwind, Glessner, G  ring, H. Coon, H. Hakonarson, H. McConachie, H. Van Engeland, Herman, Hurley, I. Drmic, I. Sousa, J. A. Lamb, J. Almeida, J. B. Vincent, J. Brian, J. Casey, J. Conroy, J. D. Buxbaum, J. Gilbert, J. Goldberg, J. Green, J. Hallmayer, J. I. Nurnberger, J. L. Haines, J. L. Howe, J. McGrath, J. Miller, J. Munson, J. P. Rice, J. Piven, J. R. Parr, J. Ragoussis, J. Rickaby, J. S. Sutcliffe, J. Salt, J. T. Glessner, J. Tsiantis, Jamain, K. Papanikolaou, K. Renshaw, K. Roeder, K. Sansom, K. Tansey, K. Wang, K. Wing, K. Wittemeyer, Kanaho, L. Cochrane, L. Gallagher, L. J. Bierut, L. Klei, L. Lotspeich, L. Senman, L. Soorya, L. Zwaigenbaum, Lee, Liu, Lord, Lord, Luca, M. A. Pericak-Vance, M. de Jonge, M. Gill, M. Hill, M. L. Cuccaro, M. L. Rutter, M. Laskawiec, M. Leboyer, Ma, Marshall, N. Bolshakova, N. J. Minshew, N. M. Melhem, N. Shah, N. Sykes, Nacher, O. Korvatska, O. Migita, Orrico, P. F. Bolton, P. Farrar, P. Szatmari, Pinto, R. Anney, R. Delorme, R. Holt, R. Igliozzi, R. M. Cantor, R. Regan, R. Segurado, R. Tancredi, Risi, S. Bolte, S. Brennan, S. C. Lund, S. E. Folstein, S. Ennis, S. F. Nelson, S. H. Chu, S. J. Guter, S. M. Klauck, S. Thomson, S. W. Scherer, S. Wallace, S. Wood, Sun, T. Berney, T. Bourgeron, T. H. Wassink, T. Paton, T. R. Magalhaes, Tao, Ter Horst, V. C. Sheffield, V. Hus, V. J. Vieland, V. Kustanovich, V. Stoppioni, Varga, W. M. McMahon, W. Mahoney, W. Roberts, Wang, Weiss, X.-Q. Liu, Z. Wang, Zhang, Zhong   +205 more
core   +7 more sources

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations. [PDF]

, 2018
Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans.
Akafo, Stephen K, Allingham, R Rand, Ashaye, Adeyinka O, Belbin, Gillian M, Bonnemaijer, Pieter WM, Bottinger, Erwin P, Cook, Colin, Eyes of Africa Genetics Consortium, GIGA Study Group, Girkin, Christopher A, Hammond, Christopher J, Hassan, Hassan G, Hauser, Michael A, Hysi, Pirro G, Iglesias, Adriana I, Kenny, Eimear E, Klaver, Caroline CW, Lemij, Hans G, Li, Zheng, Loos, Ruth JF, Meester-Smoor, Magda A, Nadkarni, Girish N, Nag, Abhishek, NEIGHBORHOOD Consortium, Ng, Maggie CY, Rotter, Jerome I, Sanyiwa, Anna J, Schurmann, Claudia, Simcoe, Mark, Taylor, Kent D, Thiadens, Alberta AHJ, van de Laar, Suzanne, van Duijn, Cornelia M, Weinreb, Robert N, Wiggs, Janey L, Wiliams, Susan EI, Zangwill, Linda M   +36 more
core  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

A perspective on interaction effects in genetic association studies

Genetic Epidemiology, 2016
The identification of gene–gene and gene–environment interaction in human traits and diseases is an active area of research that generates high expectation, and most often lead to high disappointment. This is partly explained by a misunderstanding of the
H. Aschard
semanticscholar   +1 more source

Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia

Biomolecules & Biomedicine, 2012
Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder.
Lilijana Oruč, Lejla Kapur-Pojskić, Jasmin Ramić, Naris Pojskić, Kasim Bajrović   +4 more
doaj   +1 more source

Editorial: Genetic association studies in oil seeds [PDF]

Frontiers in Genetics
V. G. Shobhana, Silvas J. P. Kirubakaran, Song Li, T. P. Parthiban   +3 more
doaj   +2 more sources

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. [PDF]

, 2014
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and ...
Abecasis, Goncalo R, Adair, Linda S, Almgren, Peter, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, Atalay, Mustafa, Aung, Tin, Baldassarre, Damiano, Balkau, Beverley, Bao, Yuqian, Barnett, Anthony H, Barroso, Ines, Basit, Abdul, Been, Latonya F, Beilby, John, Bell, Graeme I, Below, Jennifer E, Benediktsson, Rafn, Bergman, Richard N, Boehm, Bernhard O, Boerwinkle, Eric, Bonnycastle, Lori L, Burtt, Noël, Cai, Qiuyin, Campbell, Harry, Carey, Jason, Cauchi, Stephane, Caulfield, Mark, Chan, Juliana CN, Chang, Li-Ching, Chang, Tien-Jyun, Chang, Yi-Cheng, Charpentier, Guillaume, Chen, Chien-Hsiun, Chen, Han, Chen, Yuan-Tsong, Chia, Kee-Seng, Chidambaram, Manickam, Chines, Peter S, Cho, Nam H, Cho, Young Min, Chuang, Lee-Ming, Chuang, Lee-Ming, Collins, Francis S, Cornelis, Marylin C, Couper, David J, Crenshaw, Andrew T, Danesh, John, Das, Debashish, de Faire, Ulf, Dedoussis, George, Deloukas, Panos, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Dimas, Antigone S, Dina, Christian, Doney, Alex S, Donnelly, Peter J, Dorkhan, Mozhgan, Dupuis, Josée, Edkins, Sarah, Elliott, Paul, Emilsson, Valur, Erbel, Raimund, Eriksson, Johan G, Escobedo, Jorge, Esko, Tonu, Eury, Elodie, Ferreira, Teresa, Florez, Jose C, Fontanillas, Pierre, Forouhi, Nita G, Forsen, Tom, Fox, Caroline, Fraser, Ross M, Frayling, Timothy M, Froguel, Philippe, Frossard, Philippe, Gao, Yutang, Gaulton, Kyle J, Gertow, Karl, Gieger, Christian, Gigante, Bruna, Go, Min Jin, Grallert, Harald, Grant, George B, Groves, Chrisropher J, Grrop, Leif C, Horikoshi, Momoko, Johnson, Andrew D, Mahajan, Anubha, Mexican American Type 2 Diabetes (MAT2D) Consortium, Ng, Maggie CY, Prokopenko, Inga, Saleheen, Danish, South Asian Type 2 Diabetes (SAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, van Dam, Rob M, van Duijn, Cornelia, Wang, Xu, Zeggini, Eleftheria, Zhang, Weihua   +99 more
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