Results 31 to 40 of about 8,691,632 (395)

Genetic association studies in Thorax [PDF]

Thorax, 2005
A guide to assessing the validity of genetic association studies in respiratory disease Increasing knowledge regarding the extent of genetic variation in the human genome has led to an explosion of interest in performing genetic association studies in complex diseases.
John D Blakey, Ian P. Hall
openaire   +2 more sources

Genotoxicity of waterpipe smoking in young adults from Sarajevo, Bosnia & Herzegovina

Heliyon, 2023
Background: Waterpipe, also known as a hookah or narghile, is a type of tobacco products consumption device. Recently it has been increasingly popular in Bosnia and Herzegovina and the region.
Tamara Cetkovic Pecar, Anja Haveric, Lejla Caluk Klacar, Sanin Haveric, Alen Dzaferspahic, Mahira Mehanovic, Irma Durmisevic, Selma Dzaferspahic, Maida Hadzic Omanovic   +8 more
doaj  

Population stratification and genetic association studies in South Asia [PDF]

, 2005
Population stratification and its influence on genetic association studies is a controversial topic. Although it has been suggested that stratification is unlikely to bias the results of association studies conducted in developed countries, convincing ...
Bittles, A.H.
core   +2 more sources

Genetic association testing using the GENESIS R/Bioconductor package

Bioinform., 2019
SUMMARY The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes measured by microarrays and sequencing. We developed GENESIS to perform various single- and aggregate-variant association tests using genotype data stored
S. Gogarten, T. Sofer, Han Chen, Chaoyu Yu, Jennifer A. Brody, T. Thornton, K. Rice, M. Conomos   +7 more
semanticscholar   +1 more source

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. [PDF]

, 2017
Large-scale collections of induced pluripotent stem cells (iPSCs) could serve as powerful model systems for examining how genetic variation affects biology and disease.
Adler, Eric, Aguirre, Aitor, Arias, Angelo D, Benaglio, Paola, Berggren, W Travis, Borja, Victor, Chi, Neil C, Cook, Megan, D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Dargitz, Carl T, DeBoever, Christopher, Diffenderfer, Kenneth E, Donovan, Margaret KR, Drees, Frauke, Evans, Sylvia M, Farnam, KathyJean, Feiring, Rachel, Frazer, Kelly A, Garcia, Melvin, Goldstein, Lawrence SB, Greenwald, William W, Grinstein, Jonathan D, Harismendy, Olivier, Hashem, Sherin I, Hishida, Yuriko, Izpisua Belmonte, Juan Carlos, Jakubosky, David A, Jepsen, Kristen, Li, He, Loring, Jeanne F, Matsui, Hiroko, McGarry, Thomas J, Miller, Carl A, Modesto, Veronica, Müller, Franz-Josef, Nariai, Naoki, Nelson, Bradley C, O'Connor, Daniel T, Okubo, Jonathan, Panopoulos, Athanasia D, Rao, Fangwen, Reyna, Joaquin, Schuldt, Bernhard M, Smith, Erin N, Williams, Roy, Yeo, Gene W, Zhao, Chang   +47 more
core   +2 more sources

No genetic causal association between systemic lupus erythematosus and COVID-19

Frontiers in Immunology, 2023
ObjectiveEmerging evidence suggests an increased prevalence of coronavirus disease 2019 (COVID-19) in patients with systemic lupus erythematosus (SLE), the prototype of autoimmune disease, compared to the general population. However, the conclusions were
Shu-Zhen Xu, Shu-Zhen Xu, Zhi-Xin Wang, Xi Fang, Xi Fang, Cong Chen, Cong Chen, Xiao-Ke Yang, Zong-Wen Shuai, Sha-Sha Tao, Sha-Sha Tao, Sha-Sha Tao   +11 more
doaj   +1 more source

Novel associations for hypothyroidism include known autoimmune risk loci [PDF]

, 2011
Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the first large genome-wide association study of hypothyroidism, in 2,564 cases and 24,448 controls from the customer base of 23andMe, Inc.,
A Alcina, A Bender, A Petrone, A Teumer, A Zhernakova, AA Zeitlin, Amr H. Sawalha, Amy K. Kiefer, C Cotsapas, C Newton-Cheh, CB Do, Chuong B. Do, D Falush, D Smyth, David A. Hinds, F Menconi, G Lettre, H Donner, H Fraser, H Hakonarson, H Ikegami, I Landa, J Gudmundsson, J Lowe, JA Todd, JC Barrett, JC Denny, JE Wigginton, JH Cho, Joanna L. Mountain, Joyce Y. Tung, K Fujikawa, L Arnaud-Lopez, L Criswell, M Castanet, M Hayashi, M Sirota, M Velaga, MJ Coenen, MJ Simmonds, N Eriksson, N Movilla, N Tandon, Nicholas Eriksson, P Burton, P Chen, P Gourh, P Gregersen, P Newby, RC Betz, RJ Pruim, SM Park, TJ Giordano, Uta Francke, V Panicker, X Chu, Y Tomer, YH Lee   +57 more
core   +5 more sources

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Nature Genetics, 2015
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens.
J. Bentham, D. Morris, D. C. Cunninghame Graham, C. Pinder, Philip Tombleson, T. Behrens, Javier Martín, B. Fairfax, J. Knight, Lingyan Chen, J. Replogle, A. Syvänen, L. Rönnblom, R. Graham, J. Wither, J. Rioux, M. Alarcón-Riquelme, T. Vyse   +17 more
semanticscholar   +1 more source

Genetic disorders associated with macrocephaly [PDF]

American Journal of Medical Genetics Part A, 2008
AbstractMacrocephaly is associated with many genetic disorders and is a frequent cause of referral to the clinical geneticist. In this review we classify the commonly encountered macrocephaly disorders into useful categories and summarize recent genetic advances.
Williams, Charles A., Dagli, Aditi, Battaglia, Agatino   +2 more
openaire   +3 more sources

Genetic Risk and Atrial Fibrillation in Patients with Heart Failure [PDF]

, 2020
Aims: To study the association between an atrial fibrillation (AF) genetic risk score with prevalent AF and all-cause mortality in patients with heart failure.
Anker, Stefan D., Artola, Vicente A., Benjamin, Emelia J., Dickstein, Kenneth, Filippatos, Gerasimos S., Kloosterman, Mariëlle, Koekemoer, Andrea, Lam, Carolyn S. P., Lang, Chim, Meer, Peter van der, Metra, Marco, Nelson, Christopher P., Ng, Leong L., Ponikowski, Piotr, Rienstra, Michiel, Romaine, Simon P. R., Roselli, Carolina, Samani, Nilesh J., Santema, Bernadet T., van der Harst, Pim, Van Gelder, Isabelle C., Van Veldhuisen, Dirk Jan, Voors, Adriaan A.   +22 more
core   +3 more sources