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Results 31 to 40 of about 7,627,088 (344)

Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation

Platelets, 2019
Previous genome-wide association studies (GWAS) have identified several variants associated with platelet function phenotypes; however, the proportion of variance explained by the identified variants is mostly small.
Ming-Huei Chen +15 more
doaj +1 more source

Weak Association Between the Glutamate Decarboxylase 1 Gene (GAD1) and Schizophrenia in Han Chinese Population

Frontiers in Neuroscience, 2021
ObjectivesSchizophrenia (SZ) is a complex psychiatric disorder with high heritability, and genetic components are thought to be pivotal risk factors for this illness. The glutamate decarboxylase 1 gene (GAD1) was hypothesized to be a candidate risk locus
Luwen Zhang +39 more
doaj +1 more source

Investigation of the Matrix Metalloproteinase-2 Gene in Patients with Non-Syndromic Mitral Valve Prolapse

Journal of Cardiovascular Development and Disease, 2015
Non-syndromic mitral valve prolapse (MVP) is a common degenerative valvulopathy, predisposing to arrhythmia and sudden death. The etiology of MVP is suspected to be under genetic control, as supported by familial cases and its manifestation in genetic ...
Maëlle Perrocheau +7 more
doaj +1 more source

Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics

bioRxiv, 2018
Multi-SNP genetic association analysis has become increasingly important in analyzing data from genome-wide association studies (GWASs) and molecular quantitative trait loci (QTL) mapping studies.
Yeji Lee +3 more
semanticscholar +1 more source

Telomere Length and COVID-19 Outcomes: A Two-Sample Bidirectional Mendelian Randomization Study

Frontiers in Genetics, 2022
Observational studies have found a relationship between directly measured short leukocyte telomere length (LTL) and severe coronavirus disease 19 (COVID-19).
Li Jiang +11 more
doaj +1 more source

Associations between loneliness and personality are mostly driven by a genetic association with Neuroticism.

Journal of Personality, 2018
OBJECTIVE Loneliness is an aversive response to a discrepancy between desired and actual social relationships and correlates with personality. We investigate the relationship of loneliness and personality in twin family and molecular genetic data ...
A. Abdellaoui +9 more
semanticscholar +1 more source

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Nature Genetics, 2017
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified ...
N. Wray, Patrick F. Sullivan
semanticscholar +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar +8 more
wiley +1 more source

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Nature Genetics, 2015
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens.
J. Bentham +17 more
semanticscholar +1 more source

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Nature Genetics, 2022
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes.
C. Bellenguez +402 more
semanticscholar +1 more source

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