Results 31 to 40 of about 8,590,328 (320)

Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control

BMC Research Notes, 2018
Objective Clinical research on gene therapy has advanced the field of veterinary medicine, and gene doping, which is the illegal use of gene therapy, has become a major concern in horseracing. Since the International Federation of Horseracing Authorities
Teruaki Tozaki, Kaoru Karasawa, Yohei Minamijima, Hideaki Ishii, Mio Kikuchi, Hironaga Kakoi, Kei-ichi Hirota, Kanichi Kusano, Shun-ichi Nagata   +8 more
doaj   +1 more source

Genetic association testing using the GENESIS R/Bioconductor package

Bioinform., 2019
SUMMARY The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes measured by microarrays and sequencing. We developed GENESIS to perform various single- and aggregate-variant association tests using genotype data stored
S. Gogarten, T. Sofer, Han Chen, Chaoyu Yu, Jennifer A. Brody, T. Thornton, K. Rice, M. Conomos   +7 more
semanticscholar   +1 more source

Genotoxicity of waterpipe smoking in young adults from Sarajevo, Bosnia & Herzegovina

Heliyon, 2023
Background: Waterpipe, also known as a hookah or narghile, is a type of tobacco products consumption device. Recently it has been increasingly popular in Bosnia and Herzegovina and the region.
Tamara Cetkovic Pecar, Anja Haveric, Lejla Caluk Klacar, Sanin Haveric, Alen Dzaferspahic, Mahira Mehanovic, Irma Durmisevic, Selma Dzaferspahic, Maida Hadzic Omanovic   +8 more
doaj  

A genome-wide scan for common alleles affecting risk for autism [PDF]

, 2010
Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs).
A. Battaglia, A. C. Lionel, A. Crossett, A. D. Paterson, A. Estes, A. J. Bailey, A. Kolevzon, A. Le Couteur, A. M. Vicente, A. Merikangas, A. Noor, A. P. Monaco, A. P. Thompson, A. Pickles, A. Poustka, A. Prasad, A. R. Carson, A. T. Pagnamenta, A. Tryfon, Abrahams, Arai, B. A. Fernandez, B. Devlin, B. L. Leventhal, B. L. Yaspan, B. Parrini, B. Roge, B. S. Abrahams, B. Thiruvahindrapduram, Bailey, Baron-Cohen, Browning, Butler, Buxbaum, C. Betancur, C. Correia, C. Corsello, C. Gillberg, C. J. McDougle, C. Kim, C. Lord, C. M. Freitag, C. M. Lajonchere, C. Mantoulan, C. Noakes, C. R. Marshall, C. Strawbridge, Constantino, Cook, Cordell, D. H. Geschwind, D. J. Posey, D. Pinto, D. Sato, D. Zurawiecki, Dhami, Duan, E. A. Heron, E. Bacchelli, E. Duketis, E. Fombonne, E. H. Cook, E. L. Crawford, E. M. Wijsman, E. Maestrini, F. Duque, F. Poustka, F. Volkmar, Fernell, Fombonne, G. Baird, G. Casallo, G. D. Schellenberg, G. Dawson, G. Hughes, G. K. Mirza, G. Nygren, G. Oliveira, Geschwind, Glessner, G  ring, H. Coon, H. Hakonarson, H. McConachie, H. Van Engeland, Herman, Hurley, I. Drmic, I. Sousa, J. A. Lamb, J. Almeida, J. B. Vincent, J. Brian, J. Casey, J. Conroy, J. D. Buxbaum, J. Gilbert, J. Goldberg, J. Green, J. Hallmayer, J. I. Nurnberger, J. L. Haines, J. L. Howe, J. McGrath, J. Miller, J. Munson, J. P. Rice, J. Piven, J. R. Parr, J. Ragoussis, J. Rickaby, J. S. Sutcliffe, J. Salt, J. T. Glessner, J. Tsiantis, Jamain, K. Papanikolaou, K. Renshaw, K. Roeder, K. Sansom, K. Tansey, K. Wang, K. Wing, K. Wittemeyer, Kanaho, L. Cochrane, L. Gallagher, L. J. Bierut, L. Klei, L. Lotspeich, L. Senman, L. Soorya, L. Zwaigenbaum, Lee, Liu, Lord, Lord, Luca, M. A. Pericak-Vance, M. de Jonge, M. Gill, M. Hill, M. L. Cuccaro, M. L. Rutter, M. Laskawiec, M. Leboyer, Ma, Marshall, N. Bolshakova, N. J. Minshew, N. M. Melhem, N. Shah, N. Sykes, Nacher, O. Korvatska, O. Migita, Orrico, P. F. Bolton, P. Farrar, P. Szatmari, Pinto, R. Anney, R. Delorme, R. Holt, R. Igliozzi, R. M. Cantor, R. Regan, R. Segurado, R. Tancredi, Risi, S. Bolte, S. Brennan, S. C. Lund, S. E. Folstein, S. Ennis, S. F. Nelson, S. H. Chu, S. J. Guter, S. M. Klauck, S. Thomson, S. W. Scherer, S. Wallace, S. Wood, Sun, T. Berney, T. Bourgeron, T. H. Wassink, T. Paton, T. R. Magalhaes, Tao, Ter Horst, V. C. Sheffield, V. Hus, V. J. Vieland, V. Kustanovich, V. Stoppioni, Varga, W. M. McMahon, W. Mahoney, W. Roberts, Wang, Weiss, X.-Q. Liu, Z. Wang, Zhang, Zhong   +205 more
core   +7 more sources

ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population

Frontiers in Neuroscience, 2021
Background: Studies in animal models have suggested that aldehyde dehydrogenase 1 (encoded by ALDH1A1) protects against Parkinson’s disease (PD) by reducing toxic metabolites of dopamine.
Hui-Hui Fan, Hui-Hui Fan, Qing Guo, Jing Zheng, Yi-Zhi Lian, Shi-Shi Huang, Yue Sun, Ming Zou, Jian-Hong Zhu, Jian-Hong Zhu, Xiong Zhang, Xiong Zhang   +11 more
doaj   +1 more source

Novel associations for hypothyroidism include known autoimmune risk loci [PDF]

, 2011
Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the first large genome-wide association study of hypothyroidism, in 2,564 cases and 24,448 controls from the customer base of 23andMe, Inc.,
A Alcina, A Bender, A Petrone, A Teumer, A Zhernakova, AA Zeitlin, Amr H. Sawalha, Amy K. Kiefer, C Cotsapas, C Newton-Cheh, CB Do, Chuong B. Do, D Falush, D Smyth, David A. Hinds, F Menconi, G Lettre, H Donner, H Fraser, H Hakonarson, H Ikegami, I Landa, J Gudmundsson, J Lowe, JA Todd, JC Barrett, JC Denny, JE Wigginton, JH Cho, Joanna L. Mountain, Joyce Y. Tung, K Fujikawa, L Arnaud-Lopez, L Criswell, M Castanet, M Hayashi, M Sirota, M Velaga, MJ Coenen, MJ Simmonds, N Eriksson, N Movilla, N Tandon, Nicholas Eriksson, P Burton, P Chen, P Gourh, P Gregersen, P Newby, RC Betz, RJ Pruim, SM Park, TJ Giordano, Uta Francke, V Panicker, X Chu, Y Tomer, YH Lee   +57 more
core   +4 more sources

Depression in systemic lupus erythematosus: Modifiable or inheritable? a two-sample mendelian randomization study

Frontiers in Genetics, 2022
Observational studies have found increased incidence of depression, the leading cause of disability worldwide, in patients with systemic lupus erythematosus (SLE).
Jinyun Chen, Ting Xu, Min Wu
doaj   +1 more source

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models. [PDF]

, 2016
Although genome-wide association studies (GWASs) have discovered numerous novel genetic variants associated with many complex traits and diseases, those genetic variants typically explain only a small fraction of phenotypic variance. Factors that account
Bilow, Michael, Eskin, Eleazar, Furlotte, Nick, He, Dan, Kostem, Emrah, Sul, Jae Hoon, Yang, Wen-Yun   +6 more
core   +4 more sources

Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics

bioRxiv, 2018
Multi-SNP genetic association analysis has become increasingly important in analyzing data from genome-wide association studies (GWASs) and molecular quantitative trait loci (QTL) mapping studies.
Yeji Lee, Francesca Luca, R. Pique-Regi, Xiaoquan Wen   +3 more
semanticscholar   +1 more source

Editorial: Genetic association studies in oil seeds [PDF]

Frontiers in Genetics
V. G. Shobhana, Silvas J. P. Kirubakaran, Song Li, T. P. Parthiban   +3 more
doaj   +2 more sources