Results 31 to 40 of about 2,723,688 (332)

Modeling and Testing for Joint Association Using a Genetic Random Field Model [PDF]

, 2014
Substantial progress has been made in identifying single genetic variants predisposing to common complex diseases. Nonetheless, the genetic etiology of human diseases remains largely unknown.
Adler, Ballard, Besag, Besag, Browning, Burridge, Chatterjee, Cliff, Cressie, Davies, De Iorio, Gauderman, Gotze, Laird, Manolio, Molitor, Molitor, Price, Ritchie, Romeo, Rotar, Thomas, Tzeng, Wu, Wu   +24 more
core   +2 more sources

Genetic components in diabetic retinopathy

Indian Journal of Ophthalmology, 2016
Diabetic retinopathy (DR) is a serious complication of diabetes, which is fast reaching epidemic proportions worldwide. While tight glycemic control remains the standard of care for preventing the progression of DR, better insights into DR etiology ...
Bibhudatta Mishra, Anand Swaroop, Raj P Kandpal   +2 more
doaj   +1 more source

Progress in Genetic Studies of Tourette’s Syndrome

Brain Sciences, 2017
Tourette’s Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and their severity varies over time.
Yanjie Qi, Yi Zheng, Zhanjiang Li, Lan Xiong   +3 more
doaj   +1 more source

PsychArray-Based Genome Wide Association Study of Suicidal Deaths in India

Brain Sciences, 2023
Background: Suicide is a preventable but escalating global health crisis. Genome-wide association studies (GWAS) studies to date have been limited, and some are underpowered.
Chittaranjan Behera, Ruchika Kaushik, Deepak Ramkumar Bharti, Baibaswata Nayak, Daya Nand Bhardwaj, Dibyabhaba Pradhan, Harpreet Singh   +6 more
doaj   +1 more source

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs.
Alver, M, Anand, SS, Ardissino, D, Armasu, SM, Assimes, TL, Auro, K, Bertram, L, Beutner, F, Bjonnes, A, Boerwinkle, E, Borecki, IB, Bottinger, EP, Buring, JE, Chambers, JC, Chasman, DI, Chen, S, Clarke, R, Collins, R, Consortium, C, Cupples, LA, Danesh, J, de Andrade, M, de Vries, PS, Dedoussis, G, Dehghan, A, Deloukas, P, Demuth, I, Elosua, R, Epstein, SE, Erdmann, J, Esko, T, Farrall, M, Feitosa, MF, Ford, I, Franceschini, N, Franco, OH, Franzosi, MG, Frossard, P, Gauguier, D, Gieger, C, Goel, A, Goodall, AH, Gottesman, O, Grace, C, Granger, CB, Gu, D, Gudnason, V, Gustafsson, S, Haber, M, Hall, AS, Hall, LM, Hamsten, A, Han, B-G, Harris, TB, Hazen, SL, Hengstenberg, C, Hofman, A, Hopewell, JC, Huang, J, Huang, J, Hwang, S-J, Ingelsson, E, Iribarren, C, Jalilzadeh, S, Jukema, JW, Kanoni, S, Karhunen, PJ, Kathiresan, S, Kessler, T, Kim, B-J, Kim, YK, Kleber, ME, Koenig, IR, Kooner, JS, Kullo, IJ, Kyriakou, T, Lannfelt, L, Lau, KW, Lehtimaki, T, Lieb, W, Lind, L, Lindgren, CM, Lokki, M-L, Loos, RJF, Lu, X, Lu, Y, Lyytikainen, L-P, Maerz, W, Magnusson, PK, Mallick, NH, McPherson, R, Mehra, N, Meitinger, T, Melander, O, Memon, F-U-R, Metspalu, A, Mihailov, E, Morris, AP, Morrison, AC, Nelson, CP, Nieminen, MS, Nikpay, M, O'Donnell, CJ, Palmer, CN, Pedersen, NL, Perola, M, Pervjakova, N, Peters, A, Qu, L, Quertermous, T, Rader, DJ, Rallidis, LS, Rasheed, A, Reilly, MP, Ridker, PM, Ripatti, S, Roberts, R, Rose, LM, Saleheen, D, Salfati, E, Salomaa, V, Samani, NJ, Samuel, M, Sanghera, DK, Saxena, R, Scholz, M, Schunkert, H, Schwartz, SM, Seedorf, U, Shah, SH, Sinisalo, J, Smith, AV, Stewart, AF, Stirrups, KE, Stott, DJ, Thiery, J, Thompson, JR, Tikkanen, E, Trompet, S, Uitterlinden, A, van Zuydam, NR, Wang, L, Watkins, H, Webb, TR, Willenborg, C, Won, H-H, Yang, X, Zalloua, PA, Zaman, KS, Zeng, L, Zhang, W, Zhao, W   +151 more
core   +5 more sources

Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations

Frontiers in Genetics, 2019
Background: Esophageal squamous cell carcinoma (ESCC), one of the most aggressive cancers, is endemic in Sub-Saharan Africa, constituting a major health burden.
Hannah Simba, Helena Kuivaniemi, Vittoria Lutje, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Vikash Sewram   +8 more
doaj   +1 more source

Variable Effects of PD-Risk Associated SNPs and Variants in Parkinsonism-Associated Genes on Disease Phenotype in a Community-Based Cohort

Frontiers in Neurology, 2021
Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely
Katerina Markopoulou, Bruce A. Chase, Ashvini P. Premkumar, Bernadette Schoneburg, Ninith Kartha, Jun Wei, Hongjie Yu, Alexander Epshteyn, Lisette Garduno, Anna Pham, Rosa Vazquez, Roberta Frigerio, Demetrius Maraganore   +12 more
doaj   +1 more source

Population Structure and Cryptic Relatedness in Genetic Association Studies [PDF]

, 2009
We review the problem of confounding in genetic association studies, which arises principally because of population structure and cryptic relatedness. Many treatments of the problem consider only a simple ``island'' model of population structure. We take
Astle, William, Balding, David J.
core   +4 more sources

Analysis of the association between rs12917707 and rs11864909 single nucleotide polymorphisms in the region of the uromoduline gene and chronic kidney disease – a family-based study

Annals of Agricultural and Environmental Medicine, 2017
Chronic kidney disease (CKD) is an important challange for healthcare systems wordwide because of its high prevalence and serious late complications.
Joanna Żywiec, Katarzyna Kiliś-Pstrusińska, Maciej Tomaszewski, Władysław Grzeszczak   +3 more
doaj   +1 more source

ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population

Frontiers in Neuroscience, 2021
Background: Studies in animal models have suggested that aldehyde dehydrogenase 1 (encoded by ALDH1A1) protects against Parkinson’s disease (PD) by reducing toxic metabolites of dopamine.
Hui-Hui Fan, Hui-Hui Fan, Qing Guo, Jing Zheng, Yi-Zhi Lian, Shi-Shi Huang, Yue Sun, Ming Zou, Jian-Hong Zhu, Jian-Hong Zhu, Xiong Zhang, Xiong Zhang   +11 more
doaj   +1 more source