Results 41 to 50 of about 2,761,484 (346)

Systematic Review of Genomic Associations with Blood Pressure and Hypertension in Populations with African-Ancestry

Frontiers in Genetics, 2021
Background: Despite hypertension being highly prevalent in individuals with African-ancestry, they are under-represented in large genome-wide association studies.
S. Singh, S. Singh, J-T. Brandenburg, A. Choudhury, F.X. Gómez-Olivé, M. Ramsay, M. Ramsay   +6 more
doaj   +1 more source

Bayesian methods for genetic association analysis with heterogeneous subgroups: From meta-analyses to gene-environment interactions

, 2014
Genetic association analyses often involve data from multiple potentially-heterogeneous subgroups. The expected amount of heterogeneity can vary from modest (e.g., a typical meta-analysis) to large (e.g., a strong gene--environment interaction). However,
Stephens, Matthew, Wen, Xiaoquan
core   +1 more source

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs.
Alver, Maris, Anand, Sonia S., Ardissino, Diego, Armasu, Sebastian M., Assimes, Themistocles L., Auro, Kirsi, Bertram, Lars, Beutner, Frank, Bjonnes, Andrew, Boerwinkle, Eric, Borecki, Ingrid B., Bottinger, Erwin P., Buring, Julie E., Chambers, John C., Chasman, Daniel I., Chen, Shufeng, Clarke, Robert, Collins, Rory, Cupples, L. Adrienne, Danesh, John, de Andrade, Mariza, de Vries, Paul S., Dedoussis, George, Dehghan, Abbas, Deloukas, Panos, Demuth, Ilja, Elosua, Roberto, Epstein, Stephen E., Erdmann, Jeanette, Esko, Tonu, Farrall, Martin, Feitosa, Mary F., Ford, Ian, Franceschini, Nora, Franco, Oscar H., Franzosi, Maria Grazia, Frossard, Philippe, Gauguier, Dominique, Gieger, Christian, Goel, Anuj, Goodall, Alison H., Gottesman, Omri, Grace, Christopher, Granger, Christopher B., Gu, Dongfeng, Gudnason, Vilmundur, Gustafsson, Stefan, Haber, Marc, Hall, Alistair S., Hall, Leanne M., Hamsten, Anders, Han, Bok-Ghee, Harris, Tamara B., Hazen, Stanley L., Hengstenberg, Christian, Hofman, Albert, Hopewell, Jemma C., Huang, Jianfeng, Huang, Jie, Hwang, Shih-Jen, Ingelsson, Erik, Iribarren, Carlos, Jalilzadeh, Shapour, Jukema, J. Wouter, Kanoni, Stavroula, Karhunen, Pekka J., Kathiresan, Sekar, Kessler, Thorsten, Kim, Bong-Jo, Kim, Yun Kyoung, Kleber, Marcus E., Koenig, Inke R., Kooner, Jaspal S., Kullo, Iftikhar J., Kyriakou, Theodosios, Lannfelt, Lars, Lau, King Wai, Lehtimaki, Terho, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M., Lokki, Marja-Liisa, Loos, Ruth J. F., Lu, Xiangfeng, Lu, Yingchang, Lund University., Lund University., Lund University., Lyytikainen, Leo-Pekka, Maerz, Winfried, Magnusson, Patrik K., Mallick, Nadeem H., McPherson, Ruth, Mehra, Narinder, Meitinger, Thomas, Melander, Olle,, Memon, Fazal-ur-Rehman, Metspalu, Andres, Mihailov, Evelin, Morris, Andrew P., Morrison, Alanna C., Nelson, Christopher P., Nieminen, Markku S., Nikpay, Majid, O'Donnell, Christopher J., Palmer, Colin N., Pedersen, Nancy L., Perola, Markus, Pervjakova, Natalia, Peters, Annette, Qu, Liming, Quertermous, Thomas, Rader, Daniel J., Rallidis, Loukianos S., Rasheed, Asif, Reilly, Muredach P., Ridker, Paul M., Ripatti, Samuli, Roberts, Robert, Rose, Lynda M., Saleheen, Danish, Salfati, Elias, Salomaa, Veikko, Samani, Nilesh J., Samuel, Maria, Sanghera, Dharambir K., Saxena, Richa, Scholz, Markus, Schunkert, Heribert, Schwartz, Stephen M., Seedorf, Udo, Shah, Svati H., Sinisalo, Juha, Smith, Albert V., Stewart, Alexandre F., Stirrups, Kathleen E., Stott, David J., Thiery, Joachim, Thompson, John R., Tikkanen, Emmi, Trompet, Stella, Uitterlinden, Andre, van Zuydam, Natalie R., Wang, Laiyuan, Watkins, Hugh, Webb, Thomas R., Willenborg, Christina, Won, Hong-Hee, Yang, Xueli, Zalloua, Pierre A., Zaman, Khan S., Zeng, Lingyao, Zhang, Weihua, Zhao, Wei   +153 more
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Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk

Radiology and Oncology, 2016
Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in ...
Hudler Petra, Britovsek Nina Kocevar, Grazio Snjezana Frkovic, Komel Radovan   +3 more
doaj   +1 more source

Genetic modifiers of cognitive maintenance among older adults. [PDF]

, 2014
ObjectiveIdentify genetic factors associated with cognitive maintenance in late life and assess their association with gray matter (GM) volume in brain networks affected in aging.MethodsWe conducted a genome-wide association study of ∼2.4 M markers to ...
Coppola, Giovanni, Evans, Daniel S, Kramer, Joel H, Tranah, Gregory J, Yaffe, Kristine, Yokoyama, Jennifer S   +5 more
core   +1 more source

Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children

Human Genomics, 2011
Type 2 diabetes represents an increasing health burden. Its prevalence is rising among younger age groups and differs among racial/ethnic groups. Little is known about its genetic basis, including whether there is a genetic basis for racial/ethnic ...
Klimentidis Yann C, Divers Jasmin, Casazza Krista, Beasley T, Allison David B, Fernandez Jose R   +5 more
doaj   +1 more source

Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia

Biomolecules & Biomedicine, 2012
Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder.
Lilijana Oruč, Lejla Kapur-Pojskić, Jasmin Ramić, Naris Pojskić, Kasim Bajrović   +4 more
doaj   +1 more source

Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer

Medicina, 2022
Checkpoint programmed death-1 (PD-1) has been identified as an immunosuppressive molecule implicated in the immune evasion of transformed cells. It is highly expressed in tumor cells in order to evade host immunosurveillance.
Nouf Al-Harbi, Mansoor-Ali Vaali-Mohammed, Suliman Al-Omar, Ahmed Zubaidi, Omar Al-Obeed, Maha-Hamadien Abdulla, Lamjed Mansour   +6 more
doaj   +1 more source

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the
Annu, Kavya, Baker, Matt, Bigio, Eileen, Boylan, Kevin B., Caselli, Richard J., Dickson, Dennis W., Finger, Elizabeth, Fryer, John D., Graff-Radford, Neill R., Hirsch-Reinshagen, Veronica, Hsiung, Ging-Yuek R., Kato, Masato, Keith, Julia, Kim, Hong Joo, Krieger, Charles, Kurti, Aishe, Lacomis, David, Lippa, Carol, Mackenzie, Ian R., Matchett, Billie J., Messing, James, Mesulam, Marsel, Mittag, Tanja, Murray, Melissa E., Nicholson, Alexandra M., Perkerson, Ralph B., Petersen, Ronald C., Petrucelli, Leonard, Pottier, Cyril, Purice, Maria D., Rademakers, Rosa, Rogaeva, Ekaterina, Roos, Raymond P., Sarkar, Mohona, Stewart, Heather, Taylor, J. Paul, Temirov, Jamshid, Weintraub, Sandra, Wszolek, Zbigniew K., Zinman, Lorne, Zivkovic, Sasha A., Züchner, Stephan   +41 more
core   +2 more sources

Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]

, 2020
Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D., Bell, J.D., Thomas, E.L., Thomas, E.L., Whitcher, B., Whitcher, B., Yaghootkar, H., Yaghootkar, H.   +7 more
core   +2 more sources