Results 41 to 50 of about 8,590,328 (320)

A Regression-based Approach to Robust Estimation and Inference for Genetic Covariance [PDF]

arXiv, 2021
Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex traits, and some variants are shown to be associated with multiple complex traits. Genetic covariance between two traits is defined as the underlying covariance of genetic effects and can be used to measure the shared genetic architecture.
arxiv  

Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders [PDF]

, 2015
Affective disorders are highly heritable, but few genetic risk variants have been consistently replicated in molecular genetic association studies. The common method of defining psychiatric phenotypes in molecular genetic research is either a summation ...
A Brown, A Demirkan, AE Green, BF Voight, CC Minica, DP Goldberg, DP Goldberg, F Samejima, F Stephenson, FF Chen, FV Rijsdijk, HM Kravitz, HW Marsh, HW Marsh, HW Marsh, HW Marsh, HW Marsh, J Liao, JC Barrett, K Hek, K Rousseau, L Hu, LE Duncan, LK Muthén, M Burmeister, M Eid, M Feyder, M Jansson, M Jeon, M Stafford, MEJ Wadsworth, NK Hansell, NR Wray, P McGuffin, P Sklar, P Sullivan, PH Lee, R Plomin, RL Jennrich, RL Jennrich, S Papiol, S Ripke, S van der Sluis, S van der Sluis, S van der Sluis, SE Medland, SP Reise, SP Reise, SP Reise, SP Reise, T Shah, U Reininghaus, U Reininghaus, V Panicker, W Feng, X Fan   +55 more
core   +5 more sources

A review of kernel methods for genetic association studies

Genetic Epidemiology, 2019
Evaluating the association of multiple genetic variants with a trait of interest by use of kernel‐based methods has made a significant impact on how genetic association analyses are conducted. An advantage of kernel methods is that they tend to be robust
N. Larson, Jun Chen, D. Schaid
semanticscholar   +1 more source

Associations between diurnal preference, sleep quality and externalizing behaviours: a behavioural genetic analysis [PDF]

, 2011
Background - Certain aspects of sleep co-occur with externalizing behaviours in youth, yet little is known about these associations in adults. The present study: (1) examines the associations between diurnal preference (morningness versus eveningness ...
A. M. Gregory, Achenbach, Achenbach, B. Maughan, Horne, N. L. Barclay, Neale, Plomin, R. Rowe, Roth, Semiz, Sham, Smith, T. C. Eley   +13 more
core   +1 more source

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Nature Genetics, 2015
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens.
J. Bentham, D. Morris, D. C. Cunninghame Graham, C. Pinder, Philip Tombleson, T. Behrens, Javier Martín, B. Fairfax, J. Knight, Lingyan Chen, J. Replogle, A. Syvänen, L. Rönnblom, R. Graham, J. Wither, J. Rioux, M. Alarcón-Riquelme, T. Vyse   +17 more
semanticscholar   +1 more source

Conservation of Animal Genetic Resources in the Danubian Valley

Scientific Papers Animal Science and Biotechnologies, 2023
The overall aim of gene conservation is the preservation of animal genetic resources (AnGR). Since the well balanced, diverse and healthy supply of food is a major element of the national food sovereignty, hence successful animal production is not ...
Pal Hajas
doaj  

Sepsis genomics: Stepping forward toward sepsis prevention?

International Journal of Advanced Medical and Health Research, 2014
The era of personalized medicine has already begun and now it is time to initiate personalized prevention strategies against diseases. Infectious diseases have a higher mortality than any other illness, especially in developing countries.
Benet Bosco Dhas, Hiasindh Ashmi, Ballambattu Vishnu Bhat   +2 more
doaj   +1 more source

Graphical chain models for the analysis of complex genetic diseases: an application to hypertension [PDF]

, 2002
A crucial task in modern genetic medicine is the understanding of complex genetic diseases. The main complicating features are that a combination of genetic and environmental risk factors is involved, and the phenotype of interest may be complex ...
Di Serio, C., Vicard, P.
core   +1 more source

Population Stratification in Genetic Association Studies

Current Protocols in Human Genetics, 2017
Population stratification (PS) is a primary consideration in studies of genetic determinants of human traits. Failure to control for PS may lead to confounding, causing a study to fail for lack of significant results, or resources to be wasted following ...
J. Hellwege, Jacob M. Keaton, Ayush Giri, Xiaoyi Gao, D. V. Velez Edwards, T. Edwards   +5 more
semanticscholar   +1 more source

Genetic components in diabetic retinopathy

Indian Journal of Ophthalmology, 2016
Diabetic retinopathy (DR) is a serious complication of diabetes, which is fast reaching epidemic proportions worldwide. While tight glycemic control remains the standard of care for preventing the progression of DR, better insights into DR etiology ...
Bibhudatta Mishra, Anand Swaroop, Raj P Kandpal   +2 more
doaj   +1 more source