Results 41 to 50 of about 8,825,337 (378)

Variable Effects of PD-Risk Associated SNPs and Variants in Parkinsonism-Associated Genes on Disease Phenotype in a Community-Based Cohort

Frontiers in Neurology, 2021
Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely
Katerina Markopoulou, Bruce A. Chase, Ashvini P. Premkumar, Bernadette Schoneburg, Ninith Kartha, Jun Wei, Hongjie Yu, Alexander Epshteyn, Lisette Garduno, Anna Pham, Rosa Vazquez, Roberta Frigerio, Demetrius Maraganore   +12 more
doaj   +1 more source

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease [PDF]

, 2015
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs.
Alver, M, Anand, SS, Ardissino, D, Armasu, SM, Assimes, TL, Auro, K, Bertram, L, Beutner, F, Bjonnes, A, Boerwinkle, E, Borecki, IB, Bottinger, EP, Buring, JE, Chambers, JC, Chasman, DI, Chen, S, Clarke, R, Collins, R, Consortium, C, Cupples, LA, Danesh, J, de Andrade, M, de Vries, PS, Dedoussis, G, Dehghan, A, Deloukas, P, Demuth, I, Elosua, R, Epstein, SE, Erdmann, J, Esko, T, Farrall, M, Feitosa, MF, Ford, I, Franceschini, N, Franco, OH, Franzosi, MG, Frossard, P, Gauguier, D, Gieger, C, Goel, A, Goodall, AH, Gottesman, O, Grace, C, Granger, CB, Gu, D, Gudnason, V, Gustafsson, S, Haber, M, Hall, AS, Hall, LM, Hamsten, A, Han, B-G, Harris, TB, Hazen, SL, Hengstenberg, C, Hofman, A, Hopewell, JC, Huang, J, Huang, J, Hwang, S-J, Ingelsson, E, Iribarren, C, Jalilzadeh, S, Jukema, JW, Kanoni, S, Karhunen, PJ, Kathiresan, S, Kessler, T, Kim, B-J, Kim, YK, Kleber, ME, Koenig, IR, Kooner, JS, Kullo, IJ, Kyriakou, T, Lannfelt, L, Lau, KW, Lehtimaki, T, Lieb, W, Lind, L, Lindgren, CM, Lokki, M-L, Loos, RJF, Lu, X, Lu, Y, Lyytikainen, L-P, Maerz, W, Magnusson, PK, Mallick, NH, McPherson, R, Mehra, N, Meitinger, T, Melander, O, Memon, F-U-R, Metspalu, A, Mihailov, E, Morris, AP, Morrison, AC, Nelson, CP, Nieminen, MS, Nikpay, M, O'Donnell, CJ, Palmer, CN, Pedersen, NL, Perola, M, Pervjakova, N, Peters, A, Qu, L, Quertermous, T, Rader, DJ, Rallidis, LS, Rasheed, A, Reilly, MP, Ridker, PM, Ripatti, S, Roberts, R, Rose, LM, Saleheen, D, Salfati, E, Salomaa, V, Samani, NJ, Samuel, M, Sanghera, DK, Saxena, R, Scholz, M, Schunkert, H, Schwartz, SM, Seedorf, U, Shah, SH, Sinisalo, J, Smith, AV, Stewart, AF, Stirrups, KE, Stott, DJ, Thiery, J, Thompson, JR, Tikkanen, E, Trompet, S, Uitterlinden, A, van Zuydam, NR, Wang, L, Watkins, H, Webb, TR, Willenborg, C, Won, H-H, Yang, X, Zalloua, PA, Zaman, KS, Zeng, L, Zhang, W, Zhao, W   +151 more
core   +5 more sources

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

Nature Genetics, 2015
Systemic lupus erythematosus (SLE) is a genetically complex autoimmune disease characterized by loss of immune tolerance to nuclear and cell surface antigens.
J. Bentham, D. Morris, D. C. Cunninghame Graham, C. Pinder, Philip Tombleson, T. Behrens, Javier Martín, B. Fairfax, J. Knight, Lingyan Chen, J. Replogle, A. Syvänen, L. Rönnblom, R. Graham, J. Wither, J. Rioux, M. Alarcón-Riquelme, T. Vyse   +17 more
semanticscholar   +1 more source

Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics

bioRxiv, 2018
Multi-SNP genetic association analysis has become increasingly important in analyzing data from genome-wide association studies (GWASs) and molecular quantitative trait loci (QTL) mapping studies.
Yeji Lee, Francesca Luca, R. Pique-Regi, Xiaoquan Wen   +3 more
semanticscholar   +1 more source

ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population

Frontiers in Neuroscience, 2021
Background: Studies in animal models have suggested that aldehyde dehydrogenase 1 (encoded by ALDH1A1) protects against Parkinson’s disease (PD) by reducing toxic metabolites of dopamine.
Hui-Hui Fan, Hui-Hui Fan, Qing Guo, Jing Zheng, Yi-Zhi Lian, Shi-Shi Huang, Yue Sun, Ming Zou, Jian-Hong Zhu, Jian-Hong Zhu, Xiong Zhang, Xiong Zhang   +11 more
doaj   +1 more source

A review of kernel methods for genetic association studies

Genetic Epidemiology, 2019
Evaluating the association of multiple genetic variants with a trait of interest by use of kernel‐based methods has made a significant impact on how genetic association analyses are conducted. An advantage of kernel methods is that they tend to be robust
N. Larson, Jun Chen, D. Schaid
semanticscholar   +1 more source

Population Structure and Cryptic Relatedness in Genetic Association Studies [PDF]

, 2009
We review the problem of confounding in genetic association studies, which arises principally because of population structure and cryptic relatedness. Many treatments of the problem consider only a simple ``island'' model of population structure. We take
Astle, William, Balding, David J.
core   +4 more sources

Sex Differences in Genetic Associations With Longevity [PDF]

JAMA Network Open, 2018
Sex differences in genetic associations with human longevity remain largely unknown; investigations on this topic are important for individualized health care.To explore sex differences in genetic associations with longevity.This population-based case-control study used sex-specific genome-wide association study and polygenic risk score (PRS) analyses ...
Jichun Xie, Chen Bai, Qihua Tan, Ze Yang, Liang Sun, Claudio Franceschi, Chao Nie, Zhihua Chen, Xiao-Li Tian, Lars Bolund, Jianxin Li, Elizabeth R. Hauser, Joris Deelen, Kaare Christensen, Xiaomin Liu, Angela M. O'Rand, Huashuai Chen, Huashuai Chen, Thomas T. Perls, James W. Vaupel, William K. Gottschalk, Anatoli I. Yashin, Jiehua Lu, Yong Hou, Yi Zeng, Yi Zeng, Anastasia Gurinovich, Rui Ye, Michael W. Lutz, Wei Tao, Jean-Marie Robine, Xun Xu, Junxia Min, Zhaoxue Yin, Xiaoming Shi, Yuebin Lv, Ting Ni, Enjun Xie, Jun Gu, Xiao Liu, Huanming Yang, Kenneth C. Land, Paola Sebastiani, Eline Slagboom   +43 more
openaire   +9 more sources

Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations

Genetics and Molecular Biology, 2017
Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors.
Lixia Yu, Xiaoai Zhang, Yun Zhai, Hongxing Zhang, Wei Yue, Xiumei Zhang, Zhifu Wang, Hong Zhou, Gangqiao Zhou, Feng Gong   +9 more
doaj   +1 more source

MetaGenyo: a web tool for meta-analysis of genetic association studies

BMC Bioinformatics, 2017
Genetic association studies (GAS) aims to evaluate the association between genetic variants and phenotypes. In the last few years, the number of this type of study has increased exponentially, but the results are not always reproducible due to ...
Jordi Martorell-Marugán, D. Toro-Domínguez, M. Alarcón-Riquelme, P. Carmona-Sáez   +3 more
semanticscholar   +1 more source