Introduction to Genetic Association Studies [PDF]
Cold Spring Harbor Protocols, 2012 Genetic association studies are used to find candidate genes or genome regions that contribute to a specific disease by testing for a correlation between disease status and genetic variation. This article provides a broad outline of the design and analysis of such studies, focusing on case–control studies in candidate genes or regions.
Lewis, Cathryn M, Knight, Jo
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Genome Medicine, 2022 Background Large medical centers in urban areas, like Los Angeles, care for a diverse patient population and offer the potential to study the interplay between genetic ancestry and social determinants of health.
Ruth Johnson +25 more
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A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica [PDF]
Jornal Brasileiro de PneumologiaObjective: Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis, which was recognized by the World Health Organization (WHO) as a global epidemic in 1993.
Marcos César Santos de Castro +9 more
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Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study [PDF]
, 2016 BACKGROUND The inflammatory cytokine cascade is implicated in the pathogenesis of necrotising enterocolitis (NEC). Genetic association studies of cytokine polymorphisms may help to detect molecular mechanisms that are causally related to the disease ...
Baier, R. J. +5 more
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Genetic association studies in Thorax [PDF]
Thorax, 2005 A guide to assessing the validity of genetic association studies in respiratory disease Increasing knowledge regarding the extent of genetic variation in the human genome has led to an explosion of interest in performing genetic association studies in complex diseases.
I P, Hall, J D, Blakey
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Integration of a Large-Scale Genetic Analysis Workbench Increases the Accessibility of a High-Performance Pathway-Based Analysis Method [PDF]
Genomics & Informatics, 2018 The rapid increase in genetic dataset volume has demanded extensive adoption of biological knowledge to reduce the computational complexity, and the biological pathway is one well-known source of such knowledge. In this regard, we have introduced a novel
Sungyoung Lee, Taesung Park
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Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]
, 2020 Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D. +7 more
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The role of 39 psoriasis risk variants on age of psoriasis onset. [PDF]
, 2013 Recent genome-wide association studies (GWAS) have identified multiple genetic risk factors for psoriasis, but data on their association with age of onset have been marginally explored.
Butler, Daniel +12 more
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Genetic Studies on Diabetic Microvascular Complications: Focusing on Genome-Wide Association Studies [PDF]
Endocrinology and Metabolism, 2015 Diabetes is a common metabolic disorder with a worldwide prevalence of 8.3% and is the leading cause of visual loss, end-stage renal disease and amputation.
Soo Heon Kwak, Kyong Soo Park
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Myopia genetics in genome-wide association and post-genome-wide association study era [PDF]
International Journal of Ophthalmology, 2019 Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has ...
Xuan Liao, Qing-Qing Tan, Chang-Jun Lan
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