Results 41 to 50 of about 2,429,135 (273)
Frontiers in Genetics, 2023 Determining genotype–phenotype correlations in patients with hypodontia is important for understanding disease pathogenesis, although only a few studies have elucidated it.
Shinyeop Lee +6 more
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AssocTests: An R Package for Genetic Association Studies
Journal of Statistical Software, 2020 The R package AssocTests provides some procedures which are commonly used in genetic association studies. These procedures are population stratification correction through eigenvectors, principal coordinates of clusterings, Tracy-Widom test, distance ...
Lin Wang, Wei Zhang, Qizhai Li
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Design efficiency in genetic association studies [PDF]
Statistics in Medicine, 2020 Selecting the best design for genetic association studies requires careful deliberation; different study designs can be used to scan for different genetic effects, and each design has its own set of strengths and limitations. A variety of family and unrelated control configurations are amenable to genetic association analyses, including the case ...
Miriam Gjerdevik +6 more
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Psychometric precision in phenotype definition is a useful step in molecular genetic investigation of psychiatric disorders [PDF]
, 2015 Affective disorders are highly heritable, but few genetic risk variants have been consistently replicated in molecular genetic association studies. The common method of defining psychiatric phenotypes in molecular genetic research is either a summation ...
A Brown +55 more
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Efficient inference for genetic association studies with multiple outcomes
, 2017 Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study.
Davison, Anthony C. +3 more
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Incorporating prior information into association studies. [PDF]
, 2012 UnlabelledRecent technological developments in measuring genetic variation have ushered in an era of genome-wide association studies which have discovered many genes involved in human disease.
Darnell, Gregory +3 more
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Validation in Genetic Association Studies [PDF]
Briefings in Bioinformatics, 2011 Validation of genetic associations is understood to be a cornerstone for the scientific credibility of the results. To approach this topic, the general concept of genetic association studies is introduced briefly, followed by how the term 'validation' is used in the context of genetic association studies.
openaire +2 more sources
Random Forests for Genetic Association Studies [PDF]
Statistical Applications in Genetics and Molecular Biology, 2011 The Random Forests (RF) algorithm has become a commonly used machine learning algorithm for genetic association studies. It is well suited for genetic applications since it is both computationally efficient and models genetic causal mechanisms well. With its growing ubiquity, there has been inconsistent and less than optimal use of RF in the literature.
Benjamin A, Goldstein +2 more
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Frontiers in Physiology, 2022 This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C>T polymorphism on different health-related parameters in male and female young adults.
Adrián Montes-de-Oca-García +19 more
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BMC Endocrine DisordersBackground Neuropathy is a frequent complication of diabetes mellitus, a disease that is growing exponentially worldwide. Genetic research has emerged as an important tool for better understanding its predisposition, although a systematic synthesis of ...
Daniella Vinelli-Arzubiaga +3 more
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