Results 1 to 10 of about 5,981,041 (371)

Crystalizing the Genetic Code [PDF]

Journal of Biological Physics, 2001
New developments are presented in the framework of the model introduced by the authors in refs. [1,2] and in which nucleotides as well as codons are classified in crystal bases of the quantum group U_q(sl(2)+sl(2)) in the limit q -> 0. An operator which gives the correspondence between the amino-acids and the codons is now obtained for any known ...
Frappat, L., Sciarrino, A., Sorba, P.
openaire   +6 more sources

The Stereochemical Basis of the Genetic Code and the (Mostly) Autotrophic Origin of Life [PDF]

Life, 2014
Spark-tube experiments and analysis of meteorite contents have led to the widespread notion that abiotic organic molecules were the first life components.
Juan C. Fontecilla-Camps
doaj   +2 more sources

Optogenetics with Atomic Precision─A Comprehensive Review of Optical Control of Protein Function through Genetic Code Expansion. [PDF]

Chem Rev
Charette M, Rosenblum C, Shade O, Deiters A.   +3 more
europepmc   +2 more sources

Expansion of the genetic code via expansion of the genetic alphabet

Current Opinion in Chemical Biology, 2018
Vivian T. Dien, Sydney E. Morris, Rebekah J. Karadeema, Floyd E. Romesberg   +3 more
openalex   +3 more sources

The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation

Cell Reports, 2023
Summary: Melanin is a pigment produced from the amino acid L-tyrosine in melanosomes. The CNC-family transcription factor Nrf3 is expressed in the basal layer of the epidermis, where melanocytes reside, but its melanogenic function is unclear.
Tsuyoshi Waku, Sota Nakada, Haruka Masuda, Haruna Sumi, Ayaka Wada, Shuuhei Hirose, Iori Aketa, Akira Kobayashi   +7 more
doaj   +1 more source

NRF3 activates mTORC1 arginine-dependently for cancer cell viability

iScience, 2023
Summary: Cancer cells coordinate the mTORC1 signals and the related metabolic pathways to robustly and rapidly grow in response to nutrient conditions. Although a CNC-family transcription factor NRF3 promotes cancer development, the biological relevance ...
Shuuhei Hirose, Tsuyoshi Waku, Misato Tani, Haruka Masuda, Keiko Endo, Sanae Ashitani, Iori Aketa, Hina Kitano, Sota Nakada, Ayaka Wada, Atsushi Hatanaka, Tsuyoshi Osawa, Tomoyoshi Soga, Akira Kobayashi   +13 more
doaj   +1 more source

Deciphering the genetic code of DNA methylation

Briefings Bioinform., 2021
DNA methylation plays crucial roles in many biological processes and abnormal DNA methylation patterns are often observed in diseases. Recent studies have shed light on cis-acting DNA elements that regulate locus-specific DNA methylation, which involves ...
Mengchi Wang, Vu Ngo, Wei Wang
semanticscholar   +1 more source

Genetic Code Expansion: A Brief History and Perspective

Biochemistry, 2021
Since the establishment of site-specific mutagenesis of single amino acids to interrogate protein function in the 1970s, biochemists have sought to tailor protein structure in the native cell environment.
Mia A Shandell, Zhongping Tan, V. Cornish   +2 more
semanticscholar   +1 more source

The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis

Scientific Reports, 2023
The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular pathways of misfolded or damaged protein degradation that maintain cellular proteostasis.
Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi   +9 more
doaj   +1 more source

NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition

iScience, 2021
Summary: Lipids, such as cholesterol and fatty acids, influence cell signaling, energy storage, and membrane formation. Cholesterol is biosynthesized through the mevalonate pathway, and aberrant metabolism causes metabolic diseases.
Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi   +10 more
doaj   +1 more source