Results 91 to 100 of about 5,849,979 (303)
Logic in the Light of Cognitive Science
Studies in Logic, Grammar and Rhetoric, 2016 Logical theory codifies rules of correct inferences. On the other hand, logical reasoning is typically considered as one of the most fundamental cognitive activities.
Woleński Jan
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
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The Platonic Receptacle (Hypodoché), Whitehead’s Philosophy, and Genome Evolution
Viruses, 2017 The discovery of a universal genetic code utilized by all existing organisms became the backbone of biology. The coding capacity underwent changes during evolution, but its main fluctuation results from its different reading and regulation.
Jan Svoboda, Jan Svoboda
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1996 No Abstract.
openaire +2 more sources
Xenomicrobiology: a roadmap for genetic code engineering
Microbial Biotechnology, 2016 Biology is an analytical and informational science that is becoming increasingly dependent on chemical synthesis. One example is the high‐throughput and low‐cost synthesis of DNA, which is a foundation for the research field of synthetic biology (SB ...
C. Acevedo‐Rocha, Nediljko Budisa
semanticscholar +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
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Augmenting tomato functional genomics with a genome-wide induced genetic variation resource
Frontiers in Plant ScienceInduced mutations accelerate crop improvement by providing novel disease resistance and yield alleles. However, the alleles with no perceptible phenotype but have an altered function remain hidden in mutagenized plants.
Prateek Gupta +6 more
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Quality Control During Aminoacyl-tRNA Synthesis [PDF]
Kemija u Industriji, 2006 The fidelity of translation is determined at two major points: the accuracy of aminoacyl-tRNA selection by the ribosomes and synthesis of cognate amino acid/tRNA pairs by aminoacyl-tRNA synthetases (aaRSs) in the course of the aminoacylation reaction ...
Wang, S. +7 more
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
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