Results 131 to 140 of about 431,685 (314)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Design of Robust Communication Systems Using Genetic Algorithms
, 2011 [[abstract]]This paper presents a novel genetic algorithm for jointly optimizing source and channel codes. The algorithm uses a channel-optimized vector quantizer for the source code, and a rate-punctured convolutional code for the channel code.
Yung, Hung-Chuan +2 more
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Genetic Programming with Guaranteed Constraints [PDF]
, 2002 Genetic programming is a powerful technique for automatically generating program code from a description of the desired functionality. However it is frequently distrusted by users because the programs are generated with reference to a training set, and ...
Johnson, Colin G.
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Analogies of Genetic and Chemical Code
, 2018 Starting from the previously established hypothesis on the existence of the coherence of the chemical and genetic code, new facts and new insights on the existence of essential analogies between the genetic and chemical code are presented, whereby the ...
Miloje M. Rakočević
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Computation of the genetic code [PDF]
Fifth International Conference on Advances in Bio-Informatics, Bio-Technology and Environmental Engineering - ABBE 2017, 2017 Nicolay N. Kozlov, Olga N. Kozlova
openaire +1 more source
RGFGA: An efficient representation and crossover for grouping genetic algorithms
, 2005 There is substantial research into genetic algorithms that are used to group large numbers of objects into mutually exclusive subsets based upon some fitness function. However, nearly all methods involve degeneracy to some degree.
Crampton, J, Tucker, A, Swift, S
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