Results 261 to 270 of about 431,685 (314)
Annual Review of Microbiology, 2017 The genetic code—the language used by cells to translate their genomes into proteins that perform many cellular functions—is highly conserved throughout natural life.
Takahito Mukai +2 more
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Scientific American, 1962
(a) The nature of the problem Genes are made of nucleic acid. Enzymes are made of protein. The amino acid sequence of a particular protein is synthesized under instruction from a particular piece of nucleic acid. Each protein is made of one or more polypeptide chains, synthesized by con?
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(a) The nature of the problem Genes are made of nucleic acid. Enzymes are made of protein. The amino acid sequence of a particular protein is synthesized under instruction from a particular piece of nucleic acid. Each protein is made of one or more polypeptide chains, synthesized by con?
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Chemical Communications, 2001
AbstractFor Abstract see ChemInform Abstract in Full Text.
Lei, Wang, Peter G, Schultz
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AbstractFor Abstract see ChemInform Abstract in Full Text.
Lei, Wang, Peter G, Schultz
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Reliability in the genetic code
Journal of Theoretical Biology, 1979Abstract Base sequences of φ × 174 and MS2 viruses genomes and of some mRNAs (Coat protein fd virus, Rabbit B. Globin, Rat Growth Hormone and Human Chorionic, Somatomammotropin) show a preferential use of some amino-acid codons. Based on this observation the reliability of three non-degenerate codes are analyzed.
S, Alvarado +4 more
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Reprogramming the genetic code
Nature Reviews Genetics, 2020The encoded biosynthesis of proteins provides the ultimate paradigm for high-fidelity synthesis of long polymers of defined sequence and composition, but it is limited to polymerizing the canonical amino acids. Recent advances have built on genetic code expansion - which commonly permits the cellular incorporation of one type of non-canonical amino ...
Daniel de la Torre, Jason W. Chin
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Genetics and the Origin of the Genetic Code
Origins of Life, 1974The genetic code has been analysed by a method similar to that used by Gregor Mendel. The current codon catalogue is shown to be symmetrically subdivisible into two discrete subcatalogues of eight quartets each by classifying the quartets as monocoding (for one amino acid only) vs heterocoding (for two amino acids or for amino acid plus nonsense).
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Phylogeny of genetic codes and punctuation codes within genetic codes
Biosystems, 2015Punctuation codons (starts, stops) delimit genes, reflect translation apparatus properties. Most codon reassignments involve punctuation. Here two complementary approaches classify natural genetic codes: (A) properties of amino acids assigned to codons (classical phylogeny), coding stops as X (A1, antitermination/suppressor tRNAs insert unknown ...
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A possible code in the genetic code
1995In order to analyse the genetic code, the distribution of the 64 trinucleotides w (words of 3 letters on the gene alphabet {A,C,G,T}, w∈τ={AAA,⋯,TTT}) in the prokaryotic protein coding genes (words of large sizes) is studied with autocorrelation functions.
Didier Arquès, Christian J. Michel
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Methods, 2005
A general method was recently developed that makes it possible to genetically encode unnatural amino acids (UAAs) with diverse physical, chemical or biological properties in Escherichia coli, yeast, and mammalian cells. Over 30 UAAs have been cotranslationally incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Jianming, Xie, Peter G, Schultz
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A general method was recently developed that makes it possible to genetically encode unnatural amino acids (UAAs) with diverse physical, chemical or biological properties in Escherichia coli, yeast, and mammalian cells. Over 30 UAAs have been cotranslationally incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Jianming, Xie, Peter G, Schultz
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On the Origin of the Genetic Code
Journal of Theoretical Biology, 1992The main theories which have been suggested to explain the origin of genetic code organization are discussed. The coevolution theory, which considers the genetic code as a map of the biosynthetic relationships between amino acids, seems to be based on a mechanism that links it closely to certain stages of the origin of metabolism, which makes it ...
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