Results 271 to 280 of about 431,685 (314)
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2017
Protein design is usually limited to 20 amino acids. Since the chemical abilities of these amino acids are limited, a lot of interesting functions are not applicable in protein design. We aim to enable the translational incorporation of non-canonical amino acids (ncAAs) through an expanded genetic code.
Karsten, Lennard +18 more
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Protein design is usually limited to 20 amino acids. Since the chemical abilities of these amino acids are limited, a lot of interesting functions are not applicable in protein design. We aim to enable the translational incorporation of non-canonical amino acids (ncAAs) through an expanded genetic code.
Karsten, Lennard +18 more
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Stereospecificity of the genetic code
Journal of Molecular Evolution, 1974A sterical correlation of the amino acids to their anticodon nucleotides is given. The main principle is the intercalation of the amino acid and the binding of the aliphatic amino acid hydrogen atoms through hydrogen bonds to the π-electrons of the bases.
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The evolution of the genetic code
Biochimie, 1976Summary A Model is described for the evolution of proteins within organisms in the primitive environment. The model is then used to show which chemical and biological properties of the amino acids could have been important in the evolution of the genetic code.
R P, Jorré, R N, Curnow
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Annual Review of Biophysics and Biomolecular Structure, 2006
Recently, a general method was developed that makes it possible to genetically encode unnatural amino acids with diverse physical, chemical, or biological properties in Escherichia coli, yeast, and mammalian cells. More than 30 unnatural amino acids have been incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Lei, Wang +2 more
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Recently, a general method was developed that makes it possible to genetically encode unnatural amino acids with diverse physical, chemical, or biological properties in Escherichia coli, yeast, and mammalian cells. More than 30 unnatural amino acids have been incorporated into proteins with high fidelity and efficiency by means of a unique codon and ...
Lei, Wang +2 more
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The genetic code and cyclic codes.
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1983We proposed previously a cyclic code made of 22 triplets, which we now call the AB code. It is made up of the following chain: AUGGUGCCAUUCAAGACUAUGA. The letters A, U, C, G represent the classical symbols of the (purine and pyrimidine) bases of the genetic code.
J, Demongeot, J, Besson
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Optimization and the genetic code
Origins of life and evolution of the biosphere, 1989The present paper will focus on the relation between the structure of the table of the genetic code and the evolution of primitive organisms: it will be shown that the organization of the code table according to an optimization principle based on the notion of resistance to errors can provide a criterium for selection. The ordered aspect of the genetic
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The origin of the genetic code
Biochemical and Biophysical Research Communications, 1970Abstract The codons of the genetic code would be expected to participate in the adsorption sites selecting amino acids for reaction with tRNA. A codon-anticodon site shows good correlation with corresponding amino acid structures. It seems therefore probable that the genetic code originated in an evolutionary replacement of a part of an amino acid ...
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The genetic code is not universal
BioSystemsRecently, a new genetic code with 62 sense codons, coding for 21 amino acids, and only 2 termination codons has been identified in archaea. The authors argue that the appearance of this variant of the genetic code is due to the relatively recent and complete recoding of all UAG stop codons to codons encoding for pyrrolysine.
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Scientific American, 1963
This article describes how combinations of bases, or code letters, provide the information used by cells to construct proteins from twenty common kinds of amino acids. Nirenberg recounts recent developments in the field of genetics and illustrates the components and structure of DNA and RNA, and the process of protein synthesis.
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This article describes how combinations of bases, or code letters, provide the information used by cells to construct proteins from twenty common kinds of amino acids. Nirenberg recounts recent developments in the field of genetics and illustrates the components and structure of DNA and RNA, and the process of protein synthesis.
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Trends in Genetics, 2004
More than 30 novel amino acids have been genetically encoded in response to unique triplet and quadruplet codons including fluorescent, photoreactive and redox active amino acids, glycosylated and heavy atom derived amino acids in addition to those with keto, azido and acetylenic chains.
T Ashton, Cropp, Peter G, Schultz
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More than 30 novel amino acids have been genetically encoded in response to unique triplet and quadruplet codons including fluorescent, photoreactive and redox active amino acids, glycosylated and heavy atom derived amino acids in addition to those with keto, azido and acetylenic chains.
T Ashton, Cropp, Peter G, Schultz
openaire +2 more sources