Results 281 to 290 of about 431,685 (314)
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Biochimica et Biophysica Acta (BBA) - General Subjects, 2017
In December of 1966 the last nucleotide triplet in the genetic code has been assigned (Brenner et al., 1967 [1]) thus completing years of studies aimed at deciphering the nature of the relationship between the sequences of genes and proteins. The end product, the table of the genetic code, was a crowning achievement of the quest to unravel the basic ...
Maciej, Szymanski, Jan, Barciszewski
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In December of 1966 the last nucleotide triplet in the genetic code has been assigned (Brenner et al., 1967 [1]) thus completing years of studies aimed at deciphering the nature of the relationship between the sequences of genes and proteins. The end product, the table of the genetic code, was a crowning achievement of the quest to unravel the basic ...
Maciej, Szymanski, Jan, Barciszewski
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Engineering of the genetic code
Current Opinion in BiotechnologyThe genetic code is a universally conserved mechanism that translates genetic information into proteins, consisting of 64 codons formed by four nucleotide bases. With a few exceptions, the genetic code universally encodes 20 canonical amino acids (AAs) and three stop signals, with many AAs represented by multiple codons.
Yael Cohen, Lital Alfonta
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The origin of the genetic code
Journal of Molecular Biology, 1968Abstract The general features of the genetic code are described. It is considered that originally only a few amino acids were coded, but that most of the possible codons were fairly soon brought into use. In subsequent steps additional amino acids were substituted when they were able to confer a selective advantage, until eventually the code became ...
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The Science of Nature, 1973
The origin of the genetic code is not merely an evolutionary juggling of codon assignments until some optimal configuration is achieved. It is, rather, the more interesting and profound problem of how codon assignments arose. This is part and parcel of the origin of a translating mechanism.
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The origin of the genetic code is not merely an evolutionary juggling of codon assignments until some optimal configuration is achieved. It is, rather, the more interesting and profound problem of how codon assignments arose. This is part and parcel of the origin of a translating mechanism.
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Origins of life and evolution of the biosphere, 1990
Recent findings on the genetic code are reviewed, including selenocysteine usage, deviations in the assignments of sense and nonsense codons, RNA editing, natural ribosomal frameshifts and non-orthodox codon-anticodon pairings. A multi-stage codon reading process is presented.
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Recent findings on the genetic code are reviewed, including selenocysteine usage, deviations in the assignments of sense and nonsense codons, RNA editing, natural ribosomal frameshifts and non-orthodox codon-anticodon pairings. A multi-stage codon reading process is presented.
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Nature, 2016
Gene exploration is providing unexpected insights into inflammatory bowel disease, and getting scientists closer to finding treatments that target the biological mechanisms.
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Gene exploration is providing unexpected insights into inflammatory bowel disease, and getting scientists closer to finding treatments that target the biological mechanisms.
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Collinearity and the genetic code
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966Abstract Modern knowledge of the mechanism of expression of genes derives from the idea, formulated by Beadle in 1945, that each gene determines the structure of a specific protein At that time, this was all that could be said since very little was known about the chemical structure of genes and proteins and nothing about their ...
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ON THE ORIGIN OF THE GENETIC CODE
Canadian Journal of Genetics and Cytology, 1970A detailed re-examination of the codon and the anticodon catalogues has led to the conclusion that the initiation of codons and anticodons was a coincident process with a significant doublet phase, and that a double-stranded polynucleotide was an essential feature.
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Optimization of the Genetic Code
Nature, 1967THE Atlas of Protein Sequence and Structure compiled by Eck and Dayhoff1 provides an opportunity for preliminary statistical examinations of aspects of the genetic code.
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