Results 231 to 240 of about 273,398 (272)

Artificial Intelligence as the Next Visionary in Liquid Crystal Research

Advanced Functional Materials, EarlyView.
The functions of AI in the research laboratory are becoming increasingly sophisticated, allowing the entire process of hypothesis formulation, material design, synthesis, experimental design, and reiterative testing to be automated. In our work, we conceive how the incorporation of AI in the laboratory environment will transform the role and ...
Mert O. Astam, Ouassim L'Karkouri, Danqing Liu   +2 more
wiley   +1 more source

Beyond the Edge: Charge‐Transfer Excitons in Organic Donor‐Acceptor Cocrystals

Advanced Functional Materials, EarlyView.
Complex excitonic landscapes in acene–perfluoroacene cocrystals are unveiled by polarization‐resolved optical spectroscopy and many‐body theory. This systematic study of a prototypical model system for weakly interacting donor–acceptor compounds challenges common views of charge‐transfer excitons, providing a refined conceptual framework for ...
Sebastian Anhäuser, Ana M. Valencia, Sergei I. Ivlev, Marc Zeplichal, Andreas Terfort, Caterina Cocchi, Gregor Witte   +6 more
wiley   +1 more source

iNClusive: a database collecting useful information on non-canonical amino acids and their incorporation into proteins for easier genetic code expansion implementation. [PDF]

Nucleic Acids Res
Icking LS, Riedlberger AM, Krause F, Widder J, Frederiksen AS, Stockert F, Spädt M, Edel N, Armbruster D, Forlani G, Franchini S, Kaas P, Kırpat Konak BM, Krier F, Lefebvre M, Mazraeh D, Ranniger J, Gerstenecker J, Gescher P, Voigt K, Salavei P, Gensch N, Di Ventura B, Öztürk MA.   +23 more
europepmc   +1 more source

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Genetic Code Expansion History and Modern Innovations

Chemical Reviews
The genetic code is the foundation for all life. With few exceptions, the translation of nucleic acid messages into proteins follows conserved rules, which are defined by codons that specify each of the 20 proteinogenic amino acids. For decades, leading research groups have developed a catalogue of innovative approaches to extend nature's amino acid ...
Alan Costello, Alexander A. Peterson, Pei-Hsin Chen, Rustam Bagirzadeh, David L. Lanster, Ahmed H. Badran   +5 more
openaire   +4 more sources

Enzyme redesign and genetic code expansion

Protein Engineering, Design and Selection, 2023
Abstract Enzyme design is an important application of computational protein design (CPD). It can benefit enormously from the additional chemistries provided by noncanonical amino acids (ncAAs). These can be incorporated into an ‘expanded’ genetic code, and introduced in vivo into target proteins.
Vaitea, Opuu, Thomas, Simonson
openaire   +2 more sources

Building biomaterials through genetic code expansion

Trends in Biotechnology, 2023
Genetic code expansion (GCE) enables directed incorporation of noncoded amino acids (NCAAs) and unnatural amino acids (UNAAs) into the active core that confers dedicated structure and function to engineered proteins. Many protein biomaterials are tandem repeats that intrinsically include NCAAs generated through post-translational modifications (PTMs ...
Valappil Sisila, Mohan Indhu, Janani Radhakrishnan, Niraikulam Ayyadurai   +3 more
openaire   +2 more sources

Genetic Code Expansion: Inception, Development, Commercialization

Journal of the American Chemical Society, 2021
Virtually all natural proteins are built from only 20 amino acids, and while this makes possible all the functions they perform, the ability to encode other amino acids selected for specific purposes promises to enable the discovery and production of proteins with novel functions, including therapeutic proteins with more optimal drug-like properties ...
Miglena Manandhar, Eugene Chun, Floyd E. Romesberg   +2 more
openaire   +2 more sources

Genetic Code Expansion in Mammalian Cells

2023
The expansion of the genetic code has enabled the incorporation of noncanonical amino acids (ncAAs) into a defined site of proteins. By introducing such a unique handle into the protein of interest (POI), bioorthogonal reactions can be utilized in live cells to monitor or manipulate the interaction, translocation, function, and modification of the POI.
Zhigang, Wu, Jie, Wang
openaire   +2 more sources

Genetic Code Expansion Through Quadruplet Codon Decoding

Journal of Molecular Biology, 2022
Noncanonical amino acid mutagenesis has emerged as a powerful tool for the study of protein structure and function. While triplet nonsense codons, especially the amber codon, have been widely employed, quadruplet codons have attracted attention for the potential of creating additional blank codons for noncanonical amino acids mutagenesis.
Jiantao, Guo, Wei, Niu
openaire   +2 more sources

Engineering Translation Components for Genetic Code Expansion

Journal of Molecular Biology, 2022
The expansion of the genetic code consisting of four bases and 20 amino acids into diverse building blocks has been an exciting topic in synthetic biology. Many biochemical components are involved in gene expression; therefore, adding a new component to the genetic code requires engineering many other components that interact with it.
Sooin, Kim, Hanbin, Yi, Yurie T, Kim, Hyun Soo, Lee   +3 more
openaire   +2 more sources