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Genetic Code Expansion in the Service of Bioelectrochemistry
ECS Meeting Abstracts, 2023Genetic code expansion is a method that enables the inclusion of unnatural amino acids (UAAs) into proteins by expanding the genetic code beyond the 20 canonical amino acids. This can be accomplished by introducing new codons (triplet sequences that encode specific amino acids) into the genetic code via orthogonal tRNA/synthetase pairs.
Lital Alfonta +7 more
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Genetic Code Expansion in Enteric Bacterial Pathogens
2018The genetic code expansion strategy has become an elegant method for site-specific incorporation of noncanonical amino acids with diverse functionalities into proteins of interest in bacteria, yeast, mammalian cells, and even animals. This technique allows precise labeling as well as manipulation of a given protein to dissect its physiological and/or ...
Huangtao, Zheng +2 more
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Cellular and Biophysical Applications of Genetic Code Expansion
Chemical ReviewsDespite their diverse functions, proteins are inherently constructed from a limited set of building blocks. These compositional constraints pose significant challenges to protein research and its practical applications. Strategically manipulating the cellular protein synthesis system to incorporate novel building blocks has emerged as a critical ...
Han Bin Yi +5 more
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Genetic Code Expansion in Pseudomonas putida KT2440
Emerging microorganism Pseudomonas putida KT2440 is utilized for the synthesis of biobased chemicals from renewable feedstocks and for bioremediation. However, the methods for analyzing, engineering, and regulating the biosynthetic enzymes and protein complexes in this organism remain underdeveloped.Such attempts can be advanced by the genetic code ...Tianyu, Gao, Jiantao, Guo, Wei, Niu
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Genetic Code Expansion History and Modern Innovations
Chemical ReviewsThe genetic code is the foundation for all life. With few exceptions, the translation of nucleic acid messages into proteins follows conserved rules, which are defined by codons that specify each of the 20 proteinogenic amino acids. For decades, leading research groups have developed a catalogue of innovative approaches to extend nature's amino acid ...
Alan Costello +5 more
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Protein Expression by Expansion of the Genetic Code
2006The Genetic Code consists of 64 three-base codons that code for 20 amino acids and three stop signals. Recent engineering of the cell's protein synthesis machinery has allowed unnatural amino acids to be encoded in the genetic code of prokaryotic and eukaryotic organisms.
Jason W. Chin, Thomas J. Magliery
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Genetic code expansion for ageing study
2020Halogen modified Tyr analogs (HMYs) are typical products of the Tyr residue oxidation in proteins. Their occurrence may lead to destabilized protein integrity and functions, ultimately contributing to ageing processes[1]. In this study, I investigated the effects of the HMYs on model proteins.
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Visualizing the complexity of proteins in living cells with genetic code expansion
Current Opinion in Chemical Biology, 2022Kanokpol Aphicho, Chayasith Uttamapinant
exaly
Improved Eukaryotic Genetic Code Expansion
2021Expanding the genetic code allows for incorporating amino acids not found in nature into an already extensive and constantly expanding library of known proteins. These non-standard amino acids can bring new functionality to proteins, allow for enhanced research of proteins, and keep genetically engineered organisms biologically contained in the ...
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