Results 81 to 90 of about 273,398 (272)

Genetically Encoded Libraries of Nonstandard Peptides

Journal of Nucleic Acids, 2012
The presence of a nonproteinogenic moiety in a nonstandard peptide often improves the biological properties of the peptide. Non-standard peptide libraries are therefore used to obtain valuable molecules for biological, therapeutic, and diagnostic ...
Takashi Kawakami, Hiroshi Murakami
doaj   +1 more source

On the accumulation of deleterious mutations during range expansions

, 2013
We investigate the effect of spatial range expansions on the evolution of fitness when beneficial and deleterious mutations co-segregate. We perform individual-based simulations of a uniform linear habitat and complement them with analytical ...
Dupanloup, Isabelle, Excoffier, Laurent, Kirkpatrick, Mark, Peischl, Stephan   +3 more
core   +1 more source

Information on Transcriptional Regulation and Signal Transduction of _Escherichia coli_ K-12 Integrated in the Database RegulonDB. [PDF]

, 2010
Since its inception, RegulonDB ("http://regulondb.ccg.unam.mx/":http://regulondb.ccg.unam.mx/) has been a database that compiles information about the regulation of transcription initiation of _Escherichia coli_ K-12. However, we are aware that
Alberto Santos-Zavaleta, Alberto Santos-Zavaleta, Heladia Salgado, Hilda Solano, Julio Collado-Vides, Martin Peralta-Gil, Socorro Gama-Castro, Verena Weiss   +7 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Measuring microsatellite conservation in mammalian evolution with a phylogenetic birth-death model. [PDF]

, 2012
Microsatellites make up ∼3% of the human genome, and there is increasing evidence that some microsatellites can have important functions and can be conserved by selection.
Buschiazzo, Emmanuel, Gemmell, Neil, Lennon, Dustin, Minin, Vladimir N, Sawaya, Sterling M   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Practical Approaches to Genetic Code Expansion with Aminoacyl-tRNA Synthetase/tRNA Pairs

CHIMIA
Genetic code expansion (GCE) can enable the site-selective incorporation of non-canonical amino acids (ncAAs) into proteins. GCE has advanced tremendously in the last decade and can be used to create biorthogonal handles, monitor and control proteins ...
Anton Natter Perdiguero, Alexandria Deliz Liang   +1 more
doaj   +1 more source

Review on the possible interactions of pests, diseases & weeds in cereals grown in organic and conventional agriculture [PDF]

, 2001
Background The demand for organically produced food is outstripping the ability of UK farmers to supply it and the majority is imported. Furthermore, there is a major shortfall in home-produced organic cereals and cereal products, including straw.
Anon
core  

Stress related epigenetic changes may explain opportunistic success in biological invasions in Antipode mussels [PDF]

, 2018
Different environmental factors could induce epigenetic changes, which are likely involved in the biological invasion process. Some of these factors are driven by humans as, for example, the pollution and deliberate or accidental introductions and others
A Ardura, A Ardura, A Brenkert, A Pecinka, A Pérez-Figueroa, A Salmon, A Zaiko, A Zemach, AB Nicotra, AG Marsh, AK Sakai, AL Liebl, AR Linde, B Bec, B Liu, BM Turner, BR Wilson, CE Braby, CE Lee, CL Richards, DH Lim, DJ Madariaga, DL Strayer, DM Updegraff, E Briski, E Malone, F Devloo-Delva, F Valladares, FJ Santaclara, FT Chan, G Riviere, I Pejovic, J Atalah, J Fulneček, JA Rusiecki, JC Rice, JH McDonald, JM Jones, K Gérard, KJF Verhoeven, KV Kardong, L Alessa, L Excoffier, L Manti, L Miralles, M Barbieri, MA Khadim, MB Vandegehuchte, MJ Lexer, MR Gavery, MR Gavery, O Bossdorf, O Broennimann, P Colosimo, P García-Fernández, P Moran, PA Gardner, PA Jones, R Alquezar, R Karan, R Peakall, R Peakall, R Tingley, RA Zerebecki, S Gofas, S Gollasch, S Pascual, SCH Barrett, SJ Bownes, T Kohama, TJ Hilbish, V Chinnusamy, V Suarez-Ulloa, Y Sun, Ø Hammer   +74 more
core   +2 more sources