Results 51 to 60 of about 1,867,301 (331)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Molecular variation of Trypanosoma brucei subspecies as revealed by AFLP fingerprinting [PDF]
, 2002 Genetic analysis of Trypanosoma spp. depends on the detection of variation between strains. We have used the amplified fragment length polymorphism (AFLP) technique to develop a convenient and reliable method for genetic characterization of Trypanosome ...
Agbo, E.E.C. +3 more
core +8 more sources
Revista Brasileira de Zootecnia, 2004 Parâmetros genéticos foram estimados para peso na entrada da monta (PEM), considerado como indicativo do peso adulto de vacas Nelore. O arquivo de dados continha 7.902 registros de 1.556 vacas pertencentes a um experimento de seleção conduzido na Estação
Maria Eugênia Zerlotti Mercadante +4 more
doaj +1 more source
Determination of Ion Exchange Parameters by a Genetic Algorithm [PDF]
, 2005 Modeling the process of ion exchange in glass requires accurate knowledge of the self-diffusion coefficients of the incoming and outgoing ions. Furthermore, correlating the concentration profile of the incoming ions to a change in refractive index ...
Honkanen, Seppo, West, Brian R.
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2007 Estimaram-se os componentes de variância e covariância e as herdabilidades para os efeitos direto e materno, as correlações entre os efeitos direto e materno e a fração de ambiente permanente na variação total, utilizando-se o aplicativo MTDFREML, para ...
S.H.A. Ribeiro +5 more
doaj +1 more source
A new genetic algorithm for multi-label correlation-based feature selection. [PDF]
, 2015 This paper proposes a new Genetic Algorithm for Multi-Label Correlation-Based Feature Selection (GA-ML-CFS). This GA performs a global search in the space of candidate feature subset, in order to select a high-quality feature subset is used by a multi ...
Freitas, Alex A., Jungjit, Suwimol
core
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
THE EVOLUTION OF GENETIC CORRELATIONS: AN ANALYSIS OF PATTERNS [PDF]
Evolution, 1996 The genetic correlation is a central parameter of quantitative genetics, providing a measure of the rate at which traits respond to indirect selection (i.e., selection that does not act upon the traits under study, but some other trait with which they have genes in common).
openaire +3 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source