Results 51 to 60 of about 974,406 (246)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Estimação de parâmetros genéticos em tamanho de leitegada de suínos utilizando análises de características múltiplas Estimation of genetic parameters for litter size in pigs using multi-trait analyses

Revista Brasileira de Zootecnia, 2008
Registros de animais da raça Large White foram utilizados para estimar componentes de co-variâncias e parâmetros genéticos para a característica número de leitões nascidos como medida do tamanho de leitegada.
Leandro Barbosa, Paulo Sávio Lopes, Adair José Regazzi, Robledo de Almeida Torres, Mário Luiz Santana Junior, Renata Veroneze   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Análises da persistência na lactação de vacas da raça Holandesa, usando produção no dia do controle e modelo de regressão aleatória Analysis of persistency in the lactation of Holstein cows using test-day yield and random regression model

Revista Brasileira de Zootecnia, 2004
Foram utilizados 87.045 registros de produção de leite, na primeira lactação, de 11.023 vacas da raça Holandesa, obtidos nos anos de 1997 a 2001, em diferentes rebanhos distribuídos em dez núcleos do Estado de Minas Gerais.
Jaime Araujo Cobuci, Ricardo Frederico Euclydes, Claudio Napolis Costa, Paulo Sávio Lopes, Robledo de Ameida Torres, Carmen Silva Pereira   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Age-age correlation for early selection of rubber tree genotypes in São Paulo State, Brazil

Genetics and Molecular Biology, 2005
In a field trial involving 68 rubber tree (Hevea spp.) clones calculation of genotypic correlation coefficients revealed significant age-age correlation from age 1 to 6 (immature period) for girth A and for age 7 to 12 (mature period) for girth B and for
Paulo de Souza Gonçalves, Nelson Bortoletto, Átila Bento Beleti Cardinal, Lígia Regina Lima Gouvêa, Reginaldo Brito da Costa, Mário Luiz Teixeira de Moraes   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Genetic relationship between type traits, number of lactations initiated, and lifetime milk performance in Czech Fleckvieh cattle

Czech Journal of Animal Science, 2017
Genetic relationship was analyzed between type traits and longevity measures in dual-purpose cattle. Data from 91 486 Czech Fleckvieh cows first calved between 2003 and 2009 were used.
Luboš Novotný, Jan Frelich, Jan Beran, Ludmila Zavadilová   +3 more
doaj   +1 more source